Qasim Mohammed Hashim Alhelli

Abstract Background: Binding of GATA proteins is among the six members of a transcription factor family. Contributing to the luminal differentiation of breast epithelium, alongside the development of the collecting system and The process of trophoblastic differentiation. Methods: The present study collected 160 blood samples, which were divided into two groups. The first group consisted of healthy women (40), while the second group comprised patients with breast cancer (120 women). Results: ELAISA techniques were employed to assess the prognosis of breast cancer based on serum parameters associated with immuno gene transcriptions. The immunomodulatory GATA, binding protein 3, is recognized as a transcription" factor that is significant in the differentiation of breast epithelial cells. Additionally, interleukin-37 (IL-37) ,alternatively designated as Interleukin-1 family member-7, (IL-1F7), is an anti-inflammatory cytokine that is critical for the attenuation of start-inflammatory cytokine synthesis and the inhibition of cancer cell growth. The statistical analysis of the immune markers (GATA3 and IL-37) indicated a significant relationship with cancer when comparing the 120 samples collected from patients to the 40 samples from healthy individuals. The results were highly significant, with a p-value of <0.004, in Najaf Al-Ashraf. Conclusion: All immune markers indicate the presence of cancer in the body, which confirmed the clinical signs that were verified, such as redness and breast spotting, which were closely associated with the disease.

Abstract: Background: Chemotherapy remains a cornerstone of cancer therapy, yet its clinical application is often limited by severe systemic toxicities. Doxorubicin (DOX), a potent anthracycline, is associated with dose-dependent cardiotoxicity and pulmonary damage, whereas methotrexate and other cytotoxic agents also cause multi-organ toxicity. Recently, natural compounds such as artemisinin, derived from Artemisia herba-alba, have gained attention for their antioxidant and cytoprotective properties. Objectives: This study aimed to investigate the protective effects of artemisinin against doxorubicin-induced pulmonary toxicity and to evaluate its potential as a safer adjunct in chemotherapy. Materials and Methods: A total of 120 mice were divided into four groups: control (normal saline), artemisinin (60 mg/kg), doxorubicin (5 mg/kg), and a combination group receiving both agents. Treatments were administered over one-, two-, and three-week intervals. Lung tissues were collected, fixed in 10% buffered formalin, and examined histopathologically using light microscopy. Results: Histological analysis revealed severe pulmonary damage in the DOX group, characterized by bronchiolar disruption, alveolar wall destruction, and inflammatory infiltration. In contrast, the artemisinin-treated group showed normal pulmonary architecture comparable to the control. Co-administration of artemisinin and doxorubicin (ARD group) markedly reduced the severity of lung injury, demonstrating partial preservation of alveolar and bronchiolar structures. Conclusion: Artemisinin exhibited significant protective effects against doxorubicin-induced pulmonary toxicity without causing observable tissue damage on its own. These findings suggest that artemisinin may serve as a promising adjunct in chemotherapy to minimize organ-specific side effects and improve treatment safety in clinical oncology.

Abstract Background: Prostate cancer (PCa) stands as the most common type of cancer affecting men globally, exhibiting considerable differences in incidence and mortality rates across various populations. Aim the study: The study aims at the early diagnosis of prostate cancer using immunological markers. Methods: The current study, collected 240 samples blood divided into first group was a healthy which included man (60) while second group interested patients of prostate cancer from (180) man and by used ELAISA techniques for prognosis prostate cancer by serum parameters programmed cell death-ligand 1 (PDL-1and Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. Results: The statistical results of the immune markers (PDL-1, IL-6) when (180) samples collected from patients and (60) healthy showed relationship with cancer when compared with the results of healthy people. It was highly significant and p. Value <0.0011, in the Najaf Al-Ashraf. Conclusion: All immunological signs indicated the presence of cancer in the body, confirming the clinical signs approved by non-invasive diagnosis.

ABSTRACT Background: The Masks serve as a protective measure to prevent the transmission of infections, particularly in the context of the Coronavirus outbreak. There are various types of masks, including medical masks utilized in public settings like hospitals and clinics, as well as regular masks intended for use at home or during instances of coughing. As for the medical mask, it is made from three main materials: a non-woven fabric made of fine fibers connected to each other, ear straps to secure the mask on the face, in addition to a nose wire that holds the mask on the nose and keeps it in place. Purpose: this study is to know the effect of wearing a mask on blood pressure, cell size, and the expected outcome in the future. Methods: The samples were divided into groups: the first group consisted of 80 samples from employees who do not wear a mask, and this group was considered the control group. It was divided into subgroups that included males and females. The second group consisted of another 80 samples from employees who wore the mask throughout their working hours, and it was also divided into two subgroups, including 40 males and 40 females. The third and final group included samples from employees who wore the mask moderately and not throughout the working hours. This group was also divided into two subgroups, 40 males and 40 females. Results: The mean corpuscular volume (MCV) increased (84.888, 97.777, 127.804, respectively). This difference was statistically significant (p < 0.001), the ratio of red blood cells to total blood volume (RBCV) was significantly higher in women who wore masks throughout their working hours compared to women who wore masks moderately and only in crowded places. This ratio was also high but within normal limits. (57.33, 44.01, 37.98, respectively) and this variance was significant with a value of 0.001. The results were also similar in men and were also high (Hematocrit), respectively (62.01, 51.85, 42.01). This had a significant effect with (p < 0.001). Overall, women had a greater effect than men. The results were also similar for men and were also high (hct), respectively (62.01, 51.85, 42.01). This had a significant effect (p < 0.001), and overall, women had a greater effect than men. Implications: Measurement the erythropoietin hormone level of employees who wear masks, Not wearing a mask continuously during working hours and Periodic blood test for employees who wear masks continuously or intermittently and Continuous measurement of oxygen levels during working hours and Conduct kidney and liver function tests for employees who wear masks to prevent kidney failure and liver damage. Conclusion: Continuing to wear the mask affects the amount of blood produced and Increase in the average size of red blood cells as well as blood viscosity and High blood pressure and loss of energy and Unjustified nervous reactions and Forgetfulness and Early onset of polycythemia in employees who wear masks continuously the imported concluded Keywords: Mask 1, Moderately 2, Long period 3.

Abstract Background: Prostate cancer (PCa) stands as the most common type of cancer affecting men globally, exhibiting considerable differences in incidence and mortality rates across various populations. Aim the study: The study aims at the early diagnosis of prostate cancer using immunological markers. Methods: The current study, collected 240 samples blood divided into first group was a healthy which included man (60) while second group interested patients of prostate cancer from (180) man and by used ELAISA techniques for prognosis prostate cancer by serum parameters programmed cell death-ligand 1 (PDL-1and Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. Results: The statistical results of the immune markers (PDL-1, IL-6) when (180) samples collected from patients and (60) healthy showed relationship with cancer when compared with the results of healthy people. It was highly significant and p. Value <0.0011, in the Najaf Al-Ashraf. Conclusion: All immunological signs indicated the presence of cancer in the body, confirming the clinical signs approved by non-invasive diagnosis.

Abstract: The current study included a statement of the effect of the chemical compound on the kidney organ and how to reduce the effect of the chemical compound on the organs through the use of artemisinin compound and the mixture between the two compounds. Where the results showed that the compound doxorubicin affects the tissue of the kidney, where damage in cell tissue and the results of artemisinin were similar to the results of normal muse tissue, whereas the results of mixture of the two compounds had the least effect on the tissue from the effect of doxorubicin.

The College of Medicine Welcomes Students from the College of Science The College of Medicine at the University of Kufa welcomed a group of students from the College of Science, Department of Life Sciences – fourth stage, as part of the scientific visits program aimed at enhancing academic cooperation and exchanging experiences between colleges. The visit included a valuable scientific lecture given by Dr. Qasim Mohammed Hashem Al-Hilli, a faculty member in the Department of Human Anatomy, addressing the topic of comparative anatomy. He highlighted the similarities and differences in anatomy among various living organisms and explained the main applications of this scientific field in medical and research areas. The visit was also attended by the head of the Department of Human Anatomy, Assistant Professor Dr. Rasha Hatem Doush, who welcomed the students, emphasizing the importance of integrating basic sciences with medical sciences and pointing out that such activities help broaden scientific knowledge and enhance students' research skills. At the end of the visit, the students expressed their appreciation for the warm reception and the opportunity to learn about the practical and scientific aspects of the College of Medicine, noting that the visit was an important experience that added to their scientific knowledge. https://www.instagram.com/college_of

The College of Medicine Welcomes Students from Al-Furat Al-Awsat Technical University The College of Medicine at the University of Kufa welcomed a group of students from the Department of Health Physics and Radiological Therapy at Al-Furat Al-Awsat Technical University as part of a scientific program aimed at enhancing academic cooperation and exchanging expertise between the two institutions. The visit was attended by the Head of the Human Anatomy Department, Assistant Professor Dr. Rasha Hatem Doush, along with a group of the department's professors who welcomed the students, emphasizing the importance of scientific and technical integration and the role of such visits in developing knowledge and refining students' skills. The visit included a specialized scientific lecture presented by Dr. Qasim Mohammed Hashim Al-Hilli from the Human Anatomy Department, in which he covered key human anatomy topics, focusing on anatomical joints needed by radiology students, in addition to practical aspects related to medical and research fields. The lecture also witnessed a clear interaction from the students through questions and discussions, which helped enhance their understanding of the nervous and muscular system maps and emphasized their importance in the field of health physics. At the end of the visit, the students expressed their appreciation for this scientific opportunity.

The College of Medicine Welcomes First-Year Students for the New Academic Year The College of Medicine at the University of Kufa welcomed first-year students for the new academic year in a warm atmosphere that reflects the college's dedication to providing a supportive academic environment, paving the way for their scientific journey from day one. At the beginning of the ceremony, the Dean of the College, Professor Dr. Ahmad Adhab Mayan Al-Zubaidi, welcomed the new students, emphasizing that the college will dedicate all its scientific and administrative resources to offer a solid educational experience that helps prepare an outstanding generation of doctors capable of serving society. He encouraged the students to work hard, adhere to professional values, and make the most of the available expertise to achieve the highest levels of excellence. The Assistant Dean for Scientific Affairs, Professor Dr. Arafat Hussein Al-Dujaili, also highlighted the importance of students adhering to academic regulations and actively engaging with their courses, noting the college's commitment to developing its educational environment in line with international standards in medical education. The Director of the Medical Education Department presented a comprehensive introductory overview of the curriculum adopted by the college, explaining the philosophy of integrated education, assessment methods, and modern learning techniques aimed at enhancing...