قاسم محمد هاشم الحلي

Abstract Background: Binding of GATA proteins is among the six members of a transcription factor family. Contributing to the luminal differentiation of breast epithelium, alongside the development of the collecting system and The process of trophoblastic differentiation. Methods: The present study collected 160 blood samples, which were divided into two groups. The first group consisted of healthy women (40), while the second group comprised patients with breast cancer (120 women). Results: ELAISA techniques were employed to assess the prognosis of breast cancer based on serum parameters associated with immuno gene transcriptions. The immunomodulatory GATA, binding protein 3, is recognized as a transcription" factor that is significant in the differentiation of breast epithelial cells. Additionally, interleukin-37 (IL-37) ,alternatively designated as Interleukin-1 family member-7, (IL-1F7), is an anti-inflammatory cytokine that is critical for the attenuation of start-inflammatory cytokine synthesis and the inhibition of cancer cell growth. The statistical analysis of the immune markers (GATA3 and IL-37) indicated a significant relationship with cancer when comparing the 120 samples collected from patients to the 40 samples from healthy individuals. The results were highly significant, with a p-value of <0.004, in Najaf Al-Ashraf. Conclusion: All immune markers indicate the presence of cancer in the body, which confirmed the clinical signs that were verified, such as redness and breast spotting, which were closely associated with the disease.

Abstract: Background: Chemotherapy remains a cornerstone of cancer therapy, yet its clinical application is often limited by severe systemic toxicities. Doxorubicin (DOX), a potent anthracycline, is associated with dose-dependent cardiotoxicity and pulmonary damage, whereas methotrexate and other cytotoxic agents also cause multi-organ toxicity. Recently, natural compounds such as artemisinin, derived from Artemisia herba-alba, have gained attention for their antioxidant and cytoprotective properties. Objectives: This study aimed to investigate the protective effects of artemisinin against doxorubicin-induced pulmonary toxicity and to evaluate its potential as a safer adjunct in chemotherapy. Materials and Methods: A total of 120 mice were divided into four groups: control (normal saline), artemisinin (60 mg/kg), doxorubicin (5 mg/kg), and a combination group receiving both agents. Treatments were administered over one-, two-, and three-week intervals. Lung tissues were collected, fixed in 10% buffered formalin, and examined histopathologically using light microscopy. Results: Histological analysis revealed severe pulmonary damage in the DOX group, characterized by bronchiolar disruption, alveolar wall destruction, and inflammatory infiltration. In contrast, the artemisinin-treated group showed normal pulmonary architecture comparable to the control. Co-administration of artemisinin and doxorubicin (ARD group) markedly reduced the severity of lung injury, demonstrating partial preservation of alveolar and bronchiolar structures. Conclusion: Artemisinin exhibited significant protective effects against doxorubicin-induced pulmonary toxicity without causing observable tissue damage on its own. These findings suggest that artemisinin may serve as a promising adjunct in chemotherapy to minimize organ-specific side effects and improve treatment safety in clinical oncology.

Abstract Background: Prostate cancer (PCa) stands as the most common type of cancer affecting men globally, exhibiting considerable differences in incidence and mortality rates across various populations. Aim the study: The study aims at the early diagnosis of prostate cancer using immunological markers. Methods: The current study, collected 240 samples blood divided into first group was a healthy which included man (60) while second group interested patients of prostate cancer from (180) man and by used ELAISA techniques for prognosis prostate cancer by serum parameters programmed cell death-ligand 1 (PDL-1and Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. Results: The statistical results of the immune markers (PDL-1, IL-6) when (180) samples collected from patients and (60) healthy showed relationship with cancer when compared with the results of healthy people. It was highly significant and p. Value <0.0011, in the Najaf Al-Ashraf. Conclusion: All immunological signs indicated the presence of cancer in the body, confirming the clinical signs approved by non-invasive diagnosis.

ABSTRACT Background: The Masks serve as a protective measure to prevent the transmission of infections, particularly in the context of the Coronavirus outbreak. There are various types of masks, including medical masks utilized in public settings like hospitals and clinics, as well as regular masks intended for use at home or during instances of coughing. As for the medical mask, it is made from three main materials: a non-woven fabric made of fine fibers connected to each other, ear straps to secure the mask on the face, in addition to a nose wire that holds the mask on the nose and keeps it in place. Purpose: this study is to know the effect of wearing a mask on blood pressure, cell size, and the expected outcome in the future. Methods: The samples were divided into groups: the first group consisted of 80 samples from employees who do not wear a mask, and this group was considered the control group. It was divided into subgroups that included males and females. The second group consisted of another 80 samples from employees who wore the mask throughout their working hours, and it was also divided into two subgroups, including 40 males and 40 females. The third and final group included samples from employees who wore the mask moderately and not throughout the working hours. This group was also divided into two subgroups, 40 males and 40 females. Results: The mean corpuscular volume (MCV) increased (84.888, 97.777, 127.804, respectively). This difference was statistically significant (p < 0.001), the ratio of red blood cells to total blood volume (RBCV) was significantly higher in women who wore masks throughout their working hours compared to women who wore masks moderately and only in crowded places. This ratio was also high but within normal limits. (57.33, 44.01, 37.98, respectively) and this variance was significant with a value of 0.001. The results were also similar in men and were also high (Hematocrit), respectively (62.01, 51.85, 42.01). This had a significant effect with (p < 0.001). Overall, women had a greater effect than men. The results were also similar for men and were also high (hct), respectively (62.01, 51.85, 42.01). This had a significant effect (p < 0.001), and overall, women had a greater effect than men. Implications: Measurement the erythropoietin hormone level of employees who wear masks, Not wearing a mask continuously during working hours and Periodic blood test for employees who wear masks continuously or intermittently and Continuous measurement of oxygen levels during working hours and Conduct kidney and liver function tests for employees who wear masks to prevent kidney failure and liver damage. Conclusion: Continuing to wear the mask affects the amount of blood produced and Increase in the average size of red blood cells as well as blood viscosity and High blood pressure and loss of energy and Unjustified nervous reactions and Forgetfulness and Early onset of polycythemia in employees who wear masks continuously the imported concluded Keywords: Mask 1, Moderately 2, Long period 3.

Abstract Background: Prostate cancer (PCa) stands as the most common type of cancer affecting men globally, exhibiting considerable differences in incidence and mortality rates across various populations. Aim the study: The study aims at the early diagnosis of prostate cancer using immunological markers. Methods: The current study, collected 240 samples blood divided into first group was a healthy which included man (60) while second group interested patients of prostate cancer from (180) man and by used ELAISA techniques for prognosis prostate cancer by serum parameters programmed cell death-ligand 1 (PDL-1and Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. Results: The statistical results of the immune markers (PDL-1, IL-6) when (180) samples collected from patients and (60) healthy showed relationship with cancer when compared with the results of healthy people. It was highly significant and p. Value <0.0011, in the Najaf Al-Ashraf. Conclusion: All immunological signs indicated the presence of cancer in the body, confirming the clinical signs approved by non-invasive diagnosis.

Abstract: The current study included a statement of the effect of the chemical compound on the kidney organ and how to reduce the effect of the chemical compound on the organs through the use of artemisinin compound and the mixture between the two compounds. Where the results showed that the compound doxorubicin affects the tissue of the kidney, where damage in cell tissue and the results of artemisinin were similar to the results of normal muse tissue, whereas the results of mixture of the two compounds had the least effect on the tissue from the effect of doxorubicin.

كلية الطب تستقبل طلبة كلية العلوم استقبلت كلية الطب بجامعة الكوفة مجموعةً من طلبة كلية العلوم / قسم علوم الحياة – المرحلة الرابعة، وذلك ضمن برنامج الزيارات العلمية الهادف إلى تعزيز التعاون الأكاديمي وتبادل الخبرات بين الكليات. وتضمّنت الزيارة محاضرةً علمية قيّمة قدّمها التدريسي في فرع التشريح البشري الدكتور قاسم محمد هاشم الحلي، تناول فيها موضوع التشريح المقارن، مستعرضًا أوجه التشابه والاختلاف التشريحية بين مختلف الكائنات الحية، مع بيان أهم تطبيقات هذا الحقل العلمي في المجالات الطبية والبحثية. كما شهدت الزيارة حضور رئيس فرع التشريح البشري الأستاذ المساعد الدكتورة رشا حاتم دوش، التي رحّبت بالطلبة مؤكدةً أهمية التكامل بين العلوم الأساسية والعلوم الطبية، ومشيرةً إلى أن مثل هذه النشاطات تسهم في توسيع المدارك العلمية وصقل المهارات البحثية للطلبة. وفي ختام الزيارة، أعرب الطلبة عن تقديرهم لحسن الاستقبال والفرصة التي أُتيحت لهم للاطلاع على الجوانب التطبيقية والعلمية في كلية الطب، مؤكدين أن الزيارة شكّلت تجربةً مهمة أضافت إلى معارفهم العلمية. https://www.instagram.com/college_of_medicine_uok?igsh=MWNxbzUya2p6YnBtbg%3D%3D&utm_source=qr

كلية الطب تستقبل طلبة من جامعة الفرات الأوسط التقنية استقبلت كلية الطب بجامعة الكوفة مجموعة من طلبة قسم التقنيات في الفيزياء الصحية والعلاج الإشعاعي من جامعة الفرات الأوسط التقنية، ضمن برنامج علمي يهدف إلى تعزيز التعاون الأكاديمي وتبادل الخبرات بين المؤسستين. وشهدت الزيارة حضور رئيس فرع التشريح البشري الأستاذ المساعد الدكتورة رشا حاتم دوش، إلى جانب نخبة من أساتذة الفرع الذين رحّبوا بالطلبة، مؤكدين أهمية التكامل العلمي والتقني، ودور مثل هذه الزيارات في تطوير المعرفة وصقل مهارات الطلبة. وتضمّنت الزيارة محاضرة علمية متخصصة قدّمها التدريسي في فرع التشريح البشري الدكتور قاسم محمد هاشم الحلي، تناول خلالها أبرز موضوعات التشريح البشري، مع التركيز على المفاصل التشريحية التي يحتاجها طلبة العلاج الإشعاعي، إضافة إلى الجوانب التطبيقية المرتبطة بالمجالات الطبية والبحثية. كما شهدت المحاضرة تفاعلاً واضحًا من الطلبة عبر طرح الأسئلة والمناقشات، مما أسهم في تعزيز فهمهم لخرائط الجهازين العصبي والعضلي، وتأكيد أهميتها في مجال الفيزياء الصحية. وفي ختام الزيارة، أعرب الطلبة عن تقديرهم لهذه الفرصة العلمية، متطلعين إلى المزيد من النشاطات التي تسهم في إثراء معارفهم وتوسيع آفاقهم الأكاديمية. https://www.instagram.com/college_of_medicine_uok?igsh=MWNxbzUya2p6YnBtbg%3D%3D&utm_source=qr

كلية الطب تستقبل طلبة المرحلة الأولى للعام الدراسي الجديد استقبلت كلية الطب بجامعة الكوفة طلبة المرحلة الأولى للعام الدراسي الجديد، وسط أجواء ترحيبية تعكس حرص الكلية على توفير بيئة أكاديمية داعمة تُمهّد لانطلاقتهم العلمية منذ اليوم الأول. وفي مستهل الحفل، رحب عميد الكلية الأستاذ الدكتور أحمد عذاب معيان الزبيدي بالطلبة الجدد، مؤكّدًا أن الكلية ستسخر جميع إمكاناتها العلمية والإدارية لتقديم تجربة تعليمية رصينة تُسهم في إعداد جيل طبي متميز قادر على خدمة المجتمع. ودعا الطلبة إلى الجد والاجتهاد، والالتزام بقيم المهنة، والاستفادة من الخبرات المتاحة لتحقيق أعلى مستويات التفوّق. كما أكّد معاون العميد للشؤون العلمية، الأستاذ الدكتور عرفات حسين الدجيلي، أهمية التزام الطلبة بالضوابط الأكاديمية والتفاعل الجاد مع المقررات الدراسية، مشيرًا إلى حرص الكلية على تطوير بيئتها التعليمية بما ينسجم مع المعايير العالمية في التعليم الطبي. وقدّم مدير شعبة التعليم الطبي عرضًا تعريفيًا شاملًا عن المنهج الدراسي المعتمد في الكلية، موضحًا فلسفة التعليم التكاملي وآليات التقييم وأساليب التعلم الحديثة الهادفة إلى تعزيز المهارات السريرية والمعرفية لدى الطلبة. كما قدّم مسؤول الطور الأول، الأستاذ الدكتور ماجد كاظم، شرحًا تفصيليًا عن طبيعة المرحلة الأولى ومتطلبات النجاح فيها، مؤكّدًا حرصه على متابعة شؤون الطلبة وتسهيل اندماجهم في البيئة الجامعية، بما يضمن لهم بداية قوية لمسيرتهم الأكاديمية. https://www.instagram.com/college_of_medicine_uok...