كرار كاظم محمد جواد الحسني

ABSTRACT Objective: The aim of this study was to formulate, evaluate and characterise nanoemulsion formulation containing a lipophilic drug, Ketoprofen. Methods: Nanoemulsion formulations composed of oil, surfactant, co-surfactants and Ketoprofen were prepared. In all formulations, the percent of surfactants, as well as oil, was varied while the amount of Ketoprofen kept constant. Solubility studies were conducted to select the oil, surfactant and cosurfactant. Phase diagrams were constructed using the aqueous phase titration method. Formulations were selected from the phase diagrams. The prepared nanoemulsions were subjected to different thermodynamic stability tests. Results: Following optimization, the F7 formula (10% oil, 3:1 surfactant to co-surfactant) was thermodynamically stable, with a droplet size of 105 nm and a zeta potential of-26.21 mV. In vitro release study showed that the drug release pattern from formulations F5, F6, F7, F8, F9 and F10 was higher than that of F1, F2, F3 and F4. Conclusion: The present work demonstrates that the nanoemulsion is a promising drug delivery system approach for the enhancement of solubility and dissolution rate of Ketoprofen. DOWNLOADS

One of the crucial responsibilities of pharmacists is to provide Iraqi people with safe and effective medicines. Quality control tests have been performed to ensure that these medicines could meet acceptable standards of quality, efficacy, and safety. Paracetamol is an analgesic medication that is used very frequently; thus, this study aimed to quality evaluate different brands of paracetamol 500 mg tablets marketed in Iraq, four brands of paracetamol tablets were used in the study obtained from private pharmacies. Method: The selected paracetamol tablets were evaluated using standardized quality tests such as: weight variation, drug. Content uniformity, tablets hardness test, tablets friability, disintegration test, and dissolution test. Results: The tablets were assessed to check if they conform with the specifications of United States Pharmacopeia (USP). From the analysis of the results, it was observed that the weight variation showed an acceptable range. drug content in all selected paracetamol tablets was found between96.8%-101.2%; it was within the specified 85%-115% standard range. Friability tests showed that all selected tablets were within USP’s 1% mass loss limits. Doliprane and Neomol showed comparatively acceptable limits of hardness. All tablets disintegrated were within a time limit of less than 15 minutes. Additionally, an in vitro release study of the drug in 0.1 N HCl (pH 1.2) and phosphate buffer (Ph 6.8) exceeded 90% after 75 min. The FT-IR study showed that the main characteristic bands of FT-IR spectra for the active ingredient (paracetamol) were found in all-selected tablets and the FT- IR spectra of pure drug. This study concluded that all selected Paracetamol tablets were met pharmacopeial standards.

ABSTRACT Objective: The purpose of this study is to evaluate the quality control of marketed tablets containing propranolol hydrochloride available on the Iraqi market and manufactured by different companies. Methods: Different batches of propranolol hydrochloride 40 mg tablets were assessed using quality control tests. Weight variation, diameter, thickness, friability, disintegration time and dissolution study were carried out in this study. Results: Based on the data obtained in this study, all brands of PPL available on the Iraqi market showed weight variation within the acceptable limit of USP. Marketed products of Becardin and Propranolol lie within the acceptable limit of hardness and Inderal was observed to be slightly higher than the normal upper range of USP. Diameter and thickness for all brands were almost the same, except the diameter of Becardin was slightly higher and friability was zero for all brands. All brands demonstrated a time of disintegration of fewer than 30 min. The tested marketed propranolol products; Inderal, Procard, Becardin and Propranolol showed cumulative drug release of 90.08%, 94.46%, 92.4% and 79.51%, respectively at the end of the first 20 min. This variation in the release profile of marketed tablets of Propranolol HCl might be attributed to the excipients present in the marketed tablets where some of these excipients may behave as a disintegrant and enhance dissolution rate while others may act as dissolution retardants. Conclusion: All marketed tablets of Propranolol HCl employed in this study were produced within the standard criteria of tablet manufacturing. Evaluation of quality control of these selected tablets showed acceptable pharmaceutical properties that lie within the limits of USP.

Abstract Objective: The aim: In this work we developed a method of continuous recrystallization to meet industrial requirements. Patients and methods: Materials and methods: Continuous recrystallization method was investigated using porous ceramic filter for water purification with pour size less than 1 μm, that ensures high mixing rate of ethanol and water. Results: Results and conclusions: The results of experiments using crystallization through ceramic filter, gives superior products in particle size, and produced needle shaped ceftriaxone crystals form, that showed significant improvement in dissolution time and obtained ceftriaxone sodium powder to be reconstituted in injectable formula that give clear solution without insoluble microparticles.

Abstract : Ceftriaxone sodium a third generation cephalosporins antibiotic, that widely used in medical field, this study aimed to produce recrystallized ceftriaxone sodium with needle-shape by using ethanol as antisolvent and develop a process that applicable in large-scale of production. In this study ceftriaxone sodium raw powder was evaluated by UV-spectroscopic , HPLC chromatography, melting point determination and pH determination. Wherein the main steps for recrystallization process comprise:1- dissolving the ceftriaxone by water, and decolorized by using charcoal; 2- filtrate the product; 3- sterile filtration by pumping the solution through membrane; recrystallization by adding ethanol and cooling down; enable crystals growth in corresponding crystallization temperature. The product was evaluated and the crystallinity studied by P-XRD and crystals photographed by SEM, the FTIR spectroscopy confirm that no chemical interaction happen during process. The process was developed and best time and temperature was determined to produce needle-shape ceftriaxone sodium crystals that show faster dissolution time, better stability and superior quality.

وتهدف الحلقة الدراسية الى مناقشة الفرص والتحديات التي تواجه المجتمع العلمي من اجل انتاج روبوتات نانوية ذات إمكانيات تشخيصية او علاجية او كليهما وتضمنت الحلقة الدراسية استعراض لمحة تاريخية عن هذا التوجه ودور التطور التكنولوجي بطرح إمكانيات جديدة، وكذلك السبل المتبعة في تصنيع هذه الروبوتات واهم التقنيات المتبعة من خلال انتاج الحركة او الاستشعار، كما تم استعراض اخر ما تم نشره من بحوث واختراعات رصينة في هذا المجال وكذلك استعراض احدث نتاجات هذه للأبحاث وما تم تسجيله فعليا من المستحضرات الصيدلانية التي تتبع هذه التكنلوجيا. وخلاصة الحلقة الدراسية هي توجد فرصة كبيرة للباحثين العراقيين في مثل هذه البحوث من خلال التطوير للصيغ الدوائية او بحوث المحاكاة بالاخذ بنظر الاعتبار الفرص والإمكانيات والموارد المتاحة للباحثين.

جرت في كــلية الصيدلة بجامعــة الــكوفة حلقة دراسية بعنوان ( 3D Printing Technology in Pharmaceutical Dosage Forms ) التطبيقات الصيدلانية للتقنيات الطباعة ثلاثية الابعاد القاها المدرس المساعد كرار كاظم محمد جواد وحضرها كوكبة من تدريسي الكلية المنتمين لفرع الصيدلانيات والصناعات الدوائية. حيث هدفت هذه الحلقة الى التعريف بتقنيات الطباعة ثلاثية الابعاد والتطبيقات التي تخص تطوير الاشكال الدوائية باستخدام هذه التقنيات والفرص والمجالات للبحث العلمي في هذا المجال. وتضمنت هذه الحلقة استعراض اهم الأساليب والمبادئ المتبعة لتصييغ الادوية بواسطة الطباعة ثلاثية الابعاد واهم الصيغ والمستحضرات التي تم دراسة تصييغها او انتجت فعلا باستخدام هذه التقنية وكذلك الفوائد والفرص التي تواجه الباحثين بهذه التقنيات وكذلك التحديات والمصاعب وسبل تذليلها. وخلاصة الحلقة بان هذه التقنية المستمرة بالتطور بشكل مطرد تعتبر بيئة جيدة للبحث العلمي بمجالات تصييغ مستحضرات دوائية مخصصة لكل مريض من حيث المواد الفعالة وكذلك وقت طرح العلاج من المستحضر المنظم والمبرمج مسبقا.