Au‐NHC complexes with thiocarboxylate ligands: Synthesis, structure, stability, thiol exchange and in vitro anticancer activity
AuthorsHawraa S. Al-Buthabhak, Valerio Falasca, Yu Yu, Alexandre N. Sobolev, Brian W. Skelton, Stephen A. Moggach, Vito Ferro, Hani Al-Salami, Murray V. Baker
JournalJohn Wiley & Sons Ltd
Applied Organometallic Chemistry
Date2022-03-16
AbstractNovel complexes of form (NHC)Au(SCOR) (NHC = N-heterocyclic carbene, SCOR− = thiocarboxylate ligand) were synthesised and characterised by spectroscopic techniques and X-ray diffraction studies. The results of NMR and X-ray studies indicated that thiocarboxylate ligands are comparable with NHCs in their electron donor ability. The complexes were stable at room temperature in the solid state but in solution underwent disproportionation reactions to form equilibria with [Au(NHC)2]+ and [Au(SCOR)2]−. In solution, the thiocarboxylate ligand in (NHC)Au(SCOR) underwent rapid exchange with other thiocarboxylate or thiolate ligands. The (NHC)Au(SCOR) complexes showed toxicity against cisplatin-resistant ovarian cancer cells (OVCAR-8), with IC50 < 10 μM, in the range exhibited by cationic [Au(NHC)2]+ complexes well-known for their promising anticancer activity.
3,5-Dibromophenyl-functionalised imidazolium salts and their corresponding [Au(NHC)2]+ complexes: synthesis, supramolecular chemistry and anti-cancer activity
AuthorsHawraa S. Al-Buthabhak, Hawraa S. Al-Buthabhak, Yu Yu, Alexandre Sobolev, Hani Al-Salami & Murray V. Baker
JournalSpringer Nature
Date2021-06-24
AbstractThe synthesis and spectroscopic and structural characterisation of new 3,5-dibromophenyl-functionalised imidazolium salts and their corresponding [Au(NHC)2]+ complexes is reported.
Gold(i) and gold(iii) complexes of triazolyl-functionalised NHCs
AuthorsHawraa S. Al-Buthabhak, Karrar Al-Ameed, Yu Yu,Alexandre N. Sobolev, Stephen A. Moggach, Hani Al-Salami, Vito Ferro and Murray V. Baker
JournalRoyal Society of Chemistry (RSC)
Date2025-05-30
AbstractNovel triazolyl-functionalised imidazolium salts and their corresponding AuI/AuIII complexes were synthesised and characterised by spectroscopic techniques and X-ray diffraction studies.
