Au‐NHC complexes with thiocarboxylate ligands: Synthesis, structure, stability, thiol exchange and in vitro anticancer activity
الباحثونHawraa S. Al-Buthabhak، Valerio Falasca, Yu Yu, Alexandre N. Sobolev, Brian W. Skelton, Stephen A. Moggach, Vito Ferro, Hani Al-Salami, Murray V. Baker
المجلةJohn Wiley & Sons Ltd
Applied Organometallic Chemistry
التاريخ2022-03-16
مختصر البحثNovel complexes of form (NHC)Au(SCOR) (NHC = N-heterocyclic carbene, SCOR− = thiocarboxylate ligand) were synthesised and characterised by spectroscopic techniques and X-ray diffraction studies. The results of NMR and X-ray studies indicated that thiocarboxylate ligands are comparable with NHCs in their electron donor ability. The complexes were stable at room temperature in the solid state but in solution underwent disproportionation reactions to form equilibria with [Au(NHC)2]+ and [Au(SCOR)2]−. In solution, the thiocarboxylate ligand in (NHC)Au(SCOR) underwent rapid exchange with other thiocarboxylate or thiolate ligands. The (NHC)Au(SCOR) complexes showed toxicity against cisplatin-resistant ovarian cancer cells (OVCAR-8), with IC50 < 10 μM, in the range exhibited by cationic [Au(NHC)2]+ complexes well-known for their promising anticancer activity.
3,5-Dibromophenyl-functionalised imidazolium salts and their corresponding [Au(NHC)2]+ complexes: synthesis, supramolecular chemistry and anti-cancer activity
الباحثونHawraa S. Al-Buthabhak، Hawraa S. Al-Buthabhak, Yu Yu, Alexandre Sobolev, Hani Al-Salami & Murray V. Baker
المجلةSpringer Nature
التاريخ2021-06-24
مختصر البحثThe synthesis and spectroscopic and structural characterisation of new 3,5-dibromophenyl-functionalised imidazolium salts and their corresponding [Au(NHC)2]+ complexes is reported.
Gold(i) and gold(iii) complexes of triazolyl-functionalised NHCs
الباحثونHawraa S. Al-Buthabhak، Karrar Al-Ameed, Yu Yu,Alexandre N. Sobolev, Stephen A. Moggach, Hani Al-Salami, Vito Ferro and Murray V. Baker
المجلةRoyal Society of Chemistry (RSC)
التاريخ2025-05-30
مختصر البحثNovel triazolyl-functionalised imidazolium salts and their corresponding AuI/AuIII complexes were synthesised and characterised by spectroscopic techniques and X-ray diffraction studies.
