Relationship between TH1, TH2 Immune Responses and Serum SOD Activity In Scabies
الباحث الأول:
Dr.Malak Majid Almusawi
الباحثين الآخرين:
Dr. Hadi Rasool Hasan
المجلة:
Journal of Advanced Biomedical & Pathobiology Research Vol.4 No.1,
تاريخ النشر:
None
مختصر البحث:
ABSTRACT
Scabies is a common ectoparasitic contagious skin infestation globally, particularly in the developing world. Infestation invariably leads to the development of localized cutaneous inflammation, pruritis and skin lesions. The aim of this s…
ABSTRACT
Scabies is a common ectoparasitic contagious skin infestation globally, particularly in the developing world. Infestation invariably leads to the development of localized cutaneous inflammation, pruritis and skin lesions. The aim of this study was to investigate immunobiochemical response of the host's inflammatory/immune response to scabies during infestation. The present study was conducted on 60 scabietic patients who visit Dermatology Outpatient Clinic, Al-Sader Medical City in Najaf governorate/ Iraq during February 2012 till November 2012. Blood samples from 60 scabietic patients (30 early and 30 late scabietic patients) and 28 healthy and non-allergic controls were collected for eosinophils (%) count using Cell-Dyn Ruby; serum was obtained to estimate serum cytokines (IL- 1β, TNF-α, IL-4 & IL-5) and IgE using (ELISA) technique, and SOD levels. All the studied parameters were highly significant elevated (p< 0.05) in both early and late scabietic patients in comparison to control group. IgE positively correlated with IL-1β, TNF-α, IL-4 and IL-5 in early scabietic patients, whereas it had negative correlation with IL-1β, TNF-α and positive correlation with IL-4 and IL-5 in late scabietic patients. SOD showed negative correlation with IL-1β and TNF-α, whereas positive correlation appeared with IL-4 and IL-5 in both scabietic patients. In early and late scabietic patients, eosinophils (%) positively correlated with all the studied cytokines IL-1β, TNF-α, IL-4 and IL-5. The findings of the current study demonstrated that host immune response in early scabietic patients resembles a TH2 allergic response, whereas in late scabietic patients; It resembles a TH1 cell-mediated protective response.
