ضفاف زكي عزيز الطرفي

Hashimoto's thyroiditis (HT) is an autoimmune thyroid disorder shaped by both genetic predisposition and environmental influences. One gene of growing interest is interleukin-18 (IL-18), particularly its rs1946518 (T/G) promoter polymorphism, which may affect inflammatory responses. Meanwhile, vitamin D3 has emerged as a key immunomodulatory factor, yet its interaction with genetic markers in HT remains unclear

End-stage renal disease is associated with significant changes in cardiovascular function, fluid, electrolyte, acid-base balance homeostasis, bone metabolism, erythropoiesis, and blood coagulation. Between October and the end of December 2021, the study recruited (30) patients and (20) healthy control subjects. Several physiological parameters, such as (urea, creatinine, renalase, and glomerular filtration rate). The results of the current study showed that the patient groups have significant statistical significance (P≤ 0.05) levels of RNLS, Urea, GFR, and creatinine in contrast with control groups, resulting insignificantly differences (P≤ 0.05).

Background: In the past few years, the increased use of Electronic-hookah is popular among youth in Iraq, raises the need for assessment of these products on liver tissue oxidative stress. The current study aims to examine the oxidative stress induced by the vapours of Electronic-hookah on mice liver tissues. Material and Methods: Twenty mice were randomly separated into two groups. The first experimental group included albino mice were subjected to vapours of Electronic-hookah (1 hour per day for one month), and the other as a control group. At the end of the experiment, several organ weights were measured, and liver tissues were collected for all animals. Liver tissue contents of malondialdehyde, total protein carbonyl, nitric oxide were estimated. Results: The experimental data showed that Electronic-hookah (1 hour per day for one-month) had significant differences between the two groups on the relative weight of the liver and relative weight of spleen. All of the estimated oxidative damage products (malondialdehyde, total protein carbonyl, nitric oxide) were significantly higher (P<0.0001) in the E-hookah group when compared to the animals in control group. Conclusion: Vapours of Electronic-hookah have a harmful toxic effect that can promote worse oxidative stress, especially on liver tissue, which could elevate the risk for the development of liver diseases in a long time.

Single-nucleotide polymorphisms (SNPs) of antioxidant enzymes may participate to some diseases that can be associated with oxidative stress. Methodology: The blood sampled from chronic kidney disease -hemodialysis patients- (thirty patients) who visit the Dialysis center in Marjan teaching hospital /Babylon /Iraq in addition to the thirty control samples. Results: PCR-SSCP results for SOD2 gene representedthe presence of two different haplotypes due to the numbers of bands in the SOD2gene including 5 and 6 bands, these haplotypes were detected between renal failure patient groups and control, sothisindicatethe association between 5 and 6bands in patients when compared with the control group. Conclusion: The current study conclude that, SSCP technique could be a good way to detect SOD2SNPs in a patient with chronic renal failure.

ABSTRACT : The analysis of novel compound toxicity of the degree of single cell utilize flow cytometry and cellular imagingbased approach has an important role in the discovery out of compounds toxicity. We have a tendency to examine the cytotoxic effects of doxorubicin derivative (DMT) in one cultivated cellular models (RD cell line) by High Content Screening (HCS). The study found that the new compound will reduce cell count, noncontinuous Mitochondrial Membrane Potential (MMP), accumulated - cell wall porosity, nuclear condensation and unleash of cytochrome from the mitochondria into the cytosol-during this study, knowledge showed this new compound could have therapeutic consequences in sarcoma treatment merit additional development. Key words : Antitumor activity, HCS, Doxorubicin, cell viability assay.

High selectivity of Cytotoxic Activity of Compounded Anthracycline against Rhabdomyosarcoma Cancer Cell Line that effect of DMT between cancer cell and normal cell line increase the prospects that this compound could serve as leads for novel anticancer drugs and hence may be potential candidates for use in human cancer therapy, however, further investigations will be required in this regard to validate this hypothesis.

احرزت كلية العلوم بجامعة الكوفة المركز الاول والثاني في مسابقة اطروحتك في 3 دقائق التي اقامتها الجامعة بالتعاون مع جامعة كوينزلاند الاسترالية .احرزت الطالبةضفاف زكي المركزالثاني اطروحتها الموسومة ( تصميم عقار كيمياوي جديد لمعالجة احد انواع السرطانات في الاطفال) وفكرة المسابقة تتضمن استعراض طالب الدراسات العليا لاطروحته خلال ثلاث دقائق باللغة الانكليزية ويتم التنافس بين المتقدمين اعتماداً على سلامة اللغة ومهارات العرض والالقاء والمقدرة على الاحاطة بالموضوع في هذا الزمن

جرت عند الساعة 10 عرض المناقشة العلنية بمشروع بحث الدكتوراه الخاصة بي حيث تكونت اللجنة من مجموعة من اساتذة الجامعات العراقية وهم : أ. د.عدنان وحيد البديري / جامعة القادسية – كلية الطب أ. د.نجاح رايش هادي / جامعة الكوفة – كلية الطب و أ. د.عبد الهادي عباس هادي / جامعة الكوفة –كلية العلوم أ. م. د.ميساء عادل هادي / جامعة بابل –كلية العلوم أ. م. د.محمد باقر صاحب احمد / جامعة القاسم الخضراء –كلية الزراعةأ. د. مرزة حمزة حميدي المرشدي / جامعة الكوفة –كلية العلوم (عضوا ومشرفا) أ. م. د. حسين عبد الكاظم عبد الحسين/ جامعة الكوفة – كلية الطب (عضوا ومشرفا).