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زهراء محمد فاخر النفاخ
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زهراء محمد فاخر النفاخ

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الملف الشخصي

حاصله على شهادة البكالوريوس من جامعة الكوفة كلية العلوم قسم علوم الحياة (2005) في اختصاص علوم حياة عام وعلى شهادة الماجستير من جامعة الكوفة كلية العلوم قسم علوم الحياة (2014) في اختصاص فسلجة حيوانية وعلى شهادة الدكتوراه من جامعة الكوفة كلية العلوم قسم علوم الحياة (2020) في اختصاص فسلجة حيوانية .

الاهتمامات البحثية

1

البحوث المنشورة

10
2023

A Hematological and Physiological Study of Diabetes Mellitus Male Patient

الباحثونNoor alhuda Ghanem Al-Fatlawi*، Zahraa Mohammed Fakheir Al_Nafakh, Samah Amer Hammood, Sabreen Ghanem Al-Fatlawi
المجلةJournal of Research in Medical and Dental Science
مختصر البحث

Objective: Over 25 million Americans and an estimated 285 million individuals worldwide suffer with diabetes mellitus, which is linked to a heavy burden of problems. This study's goal was to assess how fasting blood glucose interacted with leukocyte counts, platelet counts, blood pressure, and body mass index. Methods: This study involved a control group of 40 individuals who appeared to be in good health and 180 male diabetic patients (70 type 1 and 70 type 2) who were randomly chosen from the diabetes mellitus center in Al-Sadder Teaching City in the province of Al-Najaf in Iraq. The age range of the control and patient groups was 35 to 65 years. Results: The results revealed a significant difference (P>0.05) in WBCs and platelet count in both type 1 and type 2 patients when compared with control groups, but a significant rise (P>0.05) in FBG in both type 1 and type 2 patients. The findings also demonstrated a significant rise in BMI and blood pressure (DBP & SBP) (P<0.05) in both type 1 and type 2 patients in comparison to the control groups, as well as a significant difference in DBP and SBP (P<0.05) between patients and control groups at various ages. Conclusion: Diabetes mellitus has been linked to higher BMIs than normal weight, and the majority of patients are obese. One of the causes of high blood pressure is DM. Patients with type 1 and type 2 diabetes do not significantly differ in their WBC and platelet counts from the control group

2022

The study for evaluate of some biochemical guidelines, impedance to insulin and BMI in polycystic ovary ladies condition in Al-Najaf Al-Ashraf city

الباحثونZahraa Mohammed AL-Nafakh
المجلةAIP Conference Proceedings 2386,
مختصر البحث

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2022

Relation of Luteinizing hormone level in females escorted by multiple cysts on ovarian condition with some parameters in AL-Najaf city

الباحثونZahraa Mohammed Fakheir AL-Nafakh1، Nooralhuda Ghanem AL-Fatlawi2 , Samah Amer Hammood³, Sabreen Ghanem Al-Fatlawi4 , Almsaid Hayder4
المجلةHiv nursing 2022:22(2);305-309
مختصر البحث

Multiple cysts on ovarian condition it is one of the generality hormonal troubles in adult females of generative prong give rise to unequal menstrual peroid, immoderate in frame or in facial hair, termination as well assterility. Concerning 80% of adult female accompanied by multiple cysts on ovarian endure from menstrual dysfunction (oligo- menorrhea, an abnormal absence of menstruation) during several mark in their sexual life and in this study (regular and irregular menstrual cycle). Regular menstrual cycle (middle extent of the menstrual cycle amidst 22 and 41 days. Either none or extreme of 1 menstrual peroids with length<22 or>41 days through the former year. Irregular cycle (middle extent of the menstrual cycle admist 22 and 41 days. Two or more menstrual peroids with length<22 or>41 days through the former year. Multiple cysts on ovarian condition is a sex hormone disorders that can influence on marital satisfaction of affected married women. The objectives of this study is assessing the levels of LH hormone according to menstrual cycle state, marital state and height. method :37adult female were diagnosed with multiple cysts on ovarian condition and19 control women recruited from Abbas AL-Nafakh laboratory in AL-Najaf AL-Ashraf city during the period from4\1\2021to9\3\2021. Patients with multiple cysts on ovarian condition were divided into groups according to menstrual cycle (regular and irregular group), marital state (married and unmarried) and height. Results: the results of this study revealed a significant increase (P<0. 05) in LH hormone level in adult female with multiple cysts on ovarian condition in comparing with control group. This treatise also showed a significant difference (P<0. 05) in LH hormone level between regular and irregular group in women with multiple cysts on ovarian condition. Also, in this treatis this results also suggest no significant variances (P>0. 05) between married group and unmarried group in adult female with multiple cysts on ovarian condition and also there no significant variances (P>0. 05) between wedded and unwed group in control women, while it was found a significant variances (P<0. 05) in wedded group between patients and control women and also it was found a significant difference (P<0. 05) in unmarried group between patients and control women. Finally the present study have been shown positive correlation (P<0. 05) between LH hormone level and height in women with multiple cysts on ovarian condition.

2022

SERUM BAFF CONCENTRATION IS USEFUL INDICATOR IN PATIENTS WITH NEWLY DIAGNOSED OF GRAVES’ DISEASE

الباحثونNoor alhuda Ghanem Al-Fatlawi1*,، Zahraa Mohammed fakher Al_Nafakh2 , Samah Amer Hammood3 and Sabreen Ghanem Al-Fatlawi4
المجلةBiochem. Cell. Arch. V
مختصر البحث

: Graves’ disease (GD) is an autoimmune disorder specific for thyroid gland causes overactive thyroid . B-cell activating factor (BAFF) of TNF family is cytokines which responsible on important a role for regulating B lymphocytes proliferation and survival. Increase level this cytokines within currency used to be celebrated of a number of kinds on autoimmune diseases. There had been no reviews focusing over the potent relationship among the activity of newly diagnosed of GD and BAFF. To discover the pathophysiologic function over BAFF of GD, we investigated serum level of BAFF in sufferers with GD. We managed fifty patients newly identified as GD and twenty five as healthy controls. We measured BAFF level in serum levels by ELISA , thyroid stimulated hormone and thyroid hormone by VIDAS in both controls and GD patients. BAFF serum level was significantly elevated in sufferers along GD compared than controls (1237.41± 71.79 pg/mL vs. 537.33±48.71pg/ mL, P< 0.05) . The serum BAFF level was considerably related to with T3 and T4 , a helpful indicator for the activity of GD. In conclusion,we conclude that BAFF concentrations are increased in GD patients, is based on pathophysiological of B-cell-driven mechanism not depended on the age and BMI but BAFF level are higher significantly in females than males.

2022

ASSESSMENT THE RELATION BETWEEN PREOPERATIVE CANCER EMBRYONIC ANTIGEN LEVEL IN SERUM AND SOME CLINICAL PARAMETERS IN PATIENTS WITH COLORECTAL CANCER DISEAS

الباحثونZahraa Mohammed Fakheir AL-NAFAKH 1، Nooralhuda Ghanem AL-FATLAWI 2 Shaymaa Hussein JABER3
المجلةminar congress 6
مختصر البحث

Colorectal malignancy (CRC) is a significant worldwide medical problem which can effect on understanding bleakness and mortality. The essential point of this examination was to research whether a preoperative rise in serum CEA is an autonomous prognostic factor for colorectal cancer patients accomplice by the connection to certain boundaries. Method:The current investigation incorporate 50 patients(25 guys and25 females) .The samples were drawn from the patients when coming to AL-Forat Al-Awsat focus in AL-Najaf city for checking and treating during the period expanded from1/8/2020 to2/9/2020. The sound gathering as control was made out of ten (10) show up as solid were gathered from lab of obsessive breaks down in AL-Najaf AL-Ashraf in various occasions. (5 ml) of venous blood were drawn from colorectal malignant growth patients and solid gathering at 9-12 A.M from bet cubital venipuncture utilizing a dispensable needle and plastic syringes. Results:The flow study demonstrated critical increase (P<0.05) in CEA level in patients with colorectal malignant growth disease (9.87±4.321) ng/ml in contrasting and control group(3.19±0.792)ng/ml ,While no noteworthy differences(p>0.05) in this examination in CEA level between male (9.18±3.176)ng/ml in contrasting and female group(10.56±5.199)ng/ml. Additionally in this investigation demonstrated there was no critical differences(p>0.05) in serum CEA level between two gatherings of ages include: ages under or equal 60 (9.11±4.318)ng/ml and ages more than 60 (11.43±3.478)ng/ml ,While serum examination of CEA in patients with colorectal malignancy malady as per stage showed there was huge increment P(<0.05) in CEA

2022

Assessment of nestin biomarker in ladies with breast malignant growth

الباحثونZahraa Mohammed AL-Nafakh,، Arshad Noori G. AL-Dujaili and Hadeel Haider Aldujaili
المجلةAIP Conference Proceedings 2386,
مختصر البحث

Chest cancer is the subsequent closed successive mostly tumors around ladies, thereafter many pores and skin disease. It is close commonly decided of women utilized 55 in congruity with 64. The point concerning the ebb and flow instruction is as per consider nestin biomarker, moreover estimated the affinity among this biomarker or a few boundaries include: bothered determination, youth, stage, standard yet physical make-up substance record between young ladies with mamma most tumors infection. Strategy: The life span existing examination covered 55 patients over AL-Najaf life span women analyzed along bosom disease. The examples have been soundness pulled adjacent to the victims at the intention in a minute illusion in conformity encircling AL-forat Al-Awsat strive for in the air AL-Najaf megalopolis suitable to battle arrest then treat quit the range of the length delayed from 1/12/2018 to 2/3/2019. The practical dispose in fastidious underline was in advance exhausted concerning of thirty-five (35) be included as ask pardon public manifest were gathered obsolete research center desist neurotic dissects central AL-Najaf AL-Ashraf of exceptional occasions. The really a for ages c in depth over vivifying rank had been coordinated touch more influenced individual ages. (5 ml) helter-skelter venous cherished had forgotten hither of bowels to the fullest extent diseases victims then solid group at 9-12 A.M past gamble cubital venipuncture the persistence of a unneeded prong then needles of plastic authoritative income: The impacts showed a on every side and wide grow (P<0.05) in nestin remainder of amenable along cherished greatest tumors infirmity into looking at along government gathering. The outcomes over this discrimination firmness naked a generous make outdo (P < durability 0,05) around nestin life-span median lobular carcinoma inside assessing along with ductal cancer. The (50- 59 y) uncover a sharp considerably (P<0.05) inside nestin stage contrasted and (40-49 y) and (60-69 y). A largish appreciative raise inside the levels contain nestin (P<0.05) in tribune 4 (Ιv) or in consequence whereof 3 between squad with breast most tumors sickness, to the fullest extent a finally The true criticism preordained life span no considerable contrasts around the levels over nestin level inside women along with bosom malignant growth problem (P>0.05) consenting after their BMI.

2022

diet to improve insulin resistance

الباحثونNooralhuda Ghanem AL-Fatlawi، Zahraa Mohammed Fakheir 2 , Rashad Kadhim Mahmood Al-Akhras 3 Sabreen Ghanim Alfatlawi 4 ,
المجلةAl-Kufa University Journal for Biology
مختصر البحث

With obesity and diabetes reaching epidemic proportions in the developed world,1 the role of insulin resistance and its sequelae is gaining prominence. According to the World Health Organization (WHO) reports, chronic illnesses contribute to 60% of death worldwide (1). Being a major chronic disease; type II diabetes (T2DM) seems to be one of the leading causes of mortality and of public health burden (2). The increasing incidence of diabetes worldwide has been highly linked to the westernized dietary patterns, physical inactivity, and increasing rates of obesity and metabolic syndrome. The healthy life style was strongly associated with 91% reduction in diabetes mellitus in females (3). The American Diabetes Association (ADA) does not recommend a specific diet over another for the diabetic patients. However, it clearly states that the total amount of fat should represent 25–35%, and saturated fat of <7% of the total calories, with monounsaturated fat as the major source of fat intake. It also points out the importance of adequate amounts of fruits, vegetables, and whole wheat cereals. On the other hand, the ADA lists three different types of diets (either lowcarbohydrate, or low-fat calorie-restricted or Mediterranean diet) as a mean for weight loss for individuals who have or are at risk of having diabetes (5). Defining the term Mediterranean diet is a great challenge given the broad geographical distribution of the Mediterranean countries and the ethnic, cultural, religious, and economic variations among them. However despite this, there is a dietary pattern characteristic of the Mediterranean diet. This includes a diet rich in fruits, vegetables, bread, cereals, olive oil as the major source of fat, low to moderate amounts of fish and poultry and alcohol, and little red meat. Assessing adherence to Mediterranean diet is not a simple task. For this reason, many indexes were developed to describe the degree of adherence to the Mediterranean diet (6

2021

Dopamine hormone means and its role in dopaminergic diseas

الباحثونZahraa Mohammed Fakheir 1,، Nooralhuda Ghanem AL-Fatlawi 2 , Shaymaa Hussein jaber3
المجلةAl-Kufa University Journal for Biology
مختصر البحث

Dopamine (DA) is the predominant catecholamine neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, cognition, emotion, positive reinforcement, food intake, and endocrine regulation. This catecholamine also plays multiple roles in the periphery as a modulator of cardiovascular function, catecholamine release, hormone secretion, vascular tone, renal function, and gastrointestinal motility[1] . The dopaminergic systems have been the focus of much research over the past 30 years, mainly because several pathological conditions such as Parkinson's disease, schizophrenia, Huntington’s disease (HD), and Addiction. Dopamine receptor antagonists have been developed to block hallucinations and delusions that occur in schizophrenic patients, whereas DA receptor agonists are effective in alleviating the hypokinesia of Parkinson's disease. However, blockade of DA receptors can induce extrapyramidal effects similar to those resulting from DA depletion, and high doses of DA agonists can cause psychoses. The therapies of disorders resulting from DA imbalances are thus associated with severe side effects. Increased activity of brain dopamine (DA) induces euphoria and approach motivation, while decreased DA activity induces dysphoria and withdrawal-like conditions[2,3]. This view of DA’s functions has been derived, in part ,from research on drugs of abuse, and thus DA is thought to play a key role in reward action of abused drugs [4,5]. In addition, DAergic dysfunction has been implicated in affective disorders[6,7]

2020

Assessment of cancer embryonic antigen (CEA) biomarker in women with breast cancer disease

الباحثونZahraa Mohammed AL-Nafakh، Arshad Noori.G.AL-Dujaili , Ammar Rasoul Mohammed.Rudha
المجلةAIP Conference Proceedings
مختصر البحث

Breast cancer (BC) is the second close frequent most cancers among women, afterwards pores and skin cancer. It is near typically determined of ladies used fifty five in conformity with 64 The aim concerning the current education is in accordance with consider plasminogen activator inhibitor-1 biomarker, additionally measured the rapport among this biomarker or some parameters include: distressed diagnosis, youth ,stage, par yet physique substance index between girls ith mamma most cancers disease. Method: The longevity existing study blanketed fifty five patients over AL-Najaf longevity ladies diagnosed along breast cancer. The samples have been stability pulled beside the sufferers when presence in conformity with AL-forat Al- Awsat center among AL-Najaf metropolis because of stability checking then treating in the course of the length prolonged from1/12/2018 to2/3/2019. The healthy team namely power was once drawn up of thirty -five (35) show up as like healthy were accrued beyond laboratory over pathological analyzes within AL-Najaf AL-Ashraf of one-of-a-kind times. The a long time over healthful crew had been matched along affected person ages.( 5 ml) about venous blood had been stretched out of breast most cancers sufferers then healthy team at 9-1A.M beyond ante cubital venipuncture the use of a disposable tine then plastic syringes. Results: The effects indicated a widespread expand (P<0.05) in PAI-1 degree of female along breast most cancers ailment into comparing along government group. The results over this learning toughness revealed a extensive make bigger (P < permanency 0,05) among PAI-1 stage within lobular carcinoma within evaluating together with ductal carcinoma. The (50-59y) revealed a noticeably appreciably (P<0.05) within PAI-1 stage compared with( 40-49y) and (60-69y). A sizeable make bigger between the levels concerning PAI-1 (P<0.05) among tribune 4 ( ΙⅤ) or value 3 between ladies with breast most cancers disease, whilst The statistical analysis confirmed longevity no substantial differences among the levels over Plasminogen activator inhibitor -1 between ladies together with breast cancer disorder (P>0.05) according after their BMI.

2020

Assessment of plasminogen activator inhibitor-1(PAI-1) biomarker in women with breast cancer disease

الباحثونZahraa Mohammed AL-Nafakh، Arshad Noori G. AL-Dujaili , Ammar Rasoul Mohammed Rudha
المجلةAIP Conference Proceedings
مختصر البحث

Breast cancer (BC) is the second close frequent most cancers among women, afterwards pores and skin cancer. It is near typically determined of ladies used fifty five in conformity with 64 The aim concerning the current education is in accordance with consider plasminogen activator inhibitor-1 biomarker, additionally measured the rapport among this biomarker or some parameters include: distressed diagnosis, youth ,stage, par yet physique substance index between girls ith mamma most cancers disease. Method: The longevity existing study blanketed fifty five patients over AL-Najaf longevity ladies diagnosed along breast cancer. The samples have been stability pulled beside the sufferers when presence in conformity with AL-forat Al- Awsat center among AL-Najaf metropolis because of stability checking then treating in the course of the length prolonged from1/12/2018 to2/3/2019. The healthy team namely power was once drawn up of thirty -five (35) show up as like healthy were accrued beyond laboratory over pathological analyzes within AL-Najaf AL-Ashraf of one-of-a-kind times. The a long time over healthful crew had been matched along affected person ages.( 5 ml) about venous blood had been stretched out of breast most cancers sufferers then healthy team at 9-1A.M beyond ante cubital venipuncture the use of a disposable tine then plastic syringes. Results: The effects indicated a widespread expand (P<0.05) in PAI-1 degree of female along breast most cancers ailment into comparing along government group. The results over this learning toughness revealed a extensive make bigger (P < permanency 0,05) among PAI-1 stage within lobular carcinoma within evaluating together with ductal carcinoma. The (50-59y) revealed a noticeably appreciably (P<0.05) within PAI-1 stage compared with( 40-49y) and (60-69y). A sizeable make bigger between the levels concerning PAI-1 (P<0.05) among tribune 4 ( ΙⅤ) or value 3 between ladies with breast most cancers disease, whilst The statistical analysis confirmed longevity no substantial differences among the levels over Plasminogen activator inhibitor -1 between ladies together with breast cancer disorder (P>0.05) according after their BMI.

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