زهراء لطيف رزاق الشبلي

he present work involves the prepare and characterization studying of 3-Nitro-2,1-(4-sulfophenyl)-3-methyi-5-pyrozolonazo phenol (3-NSPAP) as a new reagent is developed. The new 2-pyrazoline based ligand was identified by 13 C NMR, NMR and FT-IR spectra. Enhancement of nanoparticles of Al 2 O 3 and ZrO of the solutions of 3-Nitro-2,1-(4- sulfophenyl)-3-methyi-5-pyrozolonazo phenol (3-NSPAP) in aqueous solution was estimated against nanoparticles of Al 2 O 3 and ZrO and the results measured by Atomic force microscope (AFM) showed that the metal complexes have greater activity in their spectrum.

I n this study, a spectrophotometric method for the determination of low levels of palladium (II) was developed by forming a complex with the new reagent 3-(3-phenyl pyrazyl azo)-2,7-naphthalendiol (3PPAN). The complex showed maximum absorption at 612 nm with a maximum molar absorptivity of 4.911×104 L/mol/cm, and a linear correlation was established between absorbance and concentration. The accuracy and repeatability of the method were evaluated and found to be precise (RSD 1.22%) and accurate (relative error 0.157%). The method’s selectivity was also tested by evaluating the efect of various ions. The stability constant of the complex was determined to be 2.759×107 L/mol. The method was successfully applied to the determination of Pd (II) ions in environmental samples of water and soil. In addition, the new ligand (3PPAN) was used to improve the properties of nano ZnO through a ligand exchange reaction on nanoparticles

Heterocyclic moiety was mentioned to present diverse biological activities such as inhibitors of protein glycation, antibacterial, antifungal, anticancer, antidepressant, anti-inflammatory, antituberculosis, antioxidant, and as antiviral agents, in addition to other biological activities; therefore, many medicines containing heterocyclic moiety have been observed. Due to the pharmacological importance of heterocyclic derivatives, the present work comes as attempt to synthesis of heterocyclic compound involved (tetrazole and pyrazole rings) by series of steps starting from pyrimidin-2-amine, which reacted with 2-chloroacetyl chloride gave compound (1) [2-chloro-N-(pyrimidin-2-yl) acetamide], then the reflex reaction of the compound (1) with the hydrazine hydrate in ethanol led to compound (2) [2-hydrazinyl-N-(pyrimidin-2-yl)acetamide], the last one reacted with acetyl acetone to form pyrazole ring compound (3) [2-(3,5-dimethyl-1H-pyrazol-1-yl)-N-(pyrimidin-2-yl)acetamide]. In other line another pyrazole derivative was prepared by diazotization of pyrimidin-2-amine with NaNO2/HCl to azo derivative compound (4), which is reacted with acetyl acetone gave compound (5) [3-(2-(pyrimidin-2-yl)hydrazono)pentane-2,4-dione] to react with hydrazine gave pyrazole moiety compound (6) [(2-((1H-pyrazol-4-yl)diazenyl)pyrimidine]. Pyrimidin-2-amine was reacted with 4-hydroxybenzaldehyde in ethanol and glacial acetic acid gave Schiff base compound (7) , which reacted with sodium azide in dioxane to form tetrazole ring compound (8) [4-(1-(pyrimidin-2-yl)-4,5-dihydro-1H-tetrazol-5-yl)phenol]. The spectroscopic techniques were used to confirmed the chemical structures are FTIR, 1 H-NMR. The biological study of pyrazole and tetrazole derivative was evaluated as anti-bacterial against gram-negative (Klebsiella pneumoniae), gram-positive (Enterococcus faecalis) and as anti-fungal against the Candida trichomonas and Candida dubliniensis in concentration 25, 75, 50, and 100 mg/mL. It was found that pyrazole and tetrazole derivative have biological activity against the bacteria and fungi where the tetrazole ring has biological effect more than pyrazole ring

A Selective and sensitive method has been advanced for the estimation of Pd (II) This work is based on the coordination of Pd(II) with 5- [(4-Hydroxy phenyl )azo]- 4,6-dihydroxy-2-mercapto pyrimidine (HADP) to form color product ,that has a maximum absorption at( 605) nanometer and ε of( 1.11 x 104) L. mol-1.Cm-1. The relative error ,relative standard deviations and stability constant for Pd(II) were (-0.8 ,+1.2%) ,(0.51,0.72%) and 4.12 x108 L2.mole-2 .The new reagent and it complex have been prepared in ethanolic solution. Conductivity values for complex is consistent with those predicted an electrolyte.

New, simple and sensitive specteophotometric method has been developed for the determination of sulfamerazine. The method is based on the diazitization coupling reaction of sulfamerazine with resorcinol in alkaline medium were studied. The reaction gave an intense water soluble yellow product that has a maximum absorption at 422 nm and Ԑmax of 2.97 × 104 L.mole-1.cm-1. A linear correlation (1-8μg per 25ml 0.4 – 3.2 ppm) was found between absorbance at λmax and concentration. The results obtained are both precise (RSD was better than 0.8) and accurate (relative error was better than – 0.11). The coloured product was found to be 1:1 sulfamerazine: resorcinol. The stability constant and the rate constant of reaction under optimized conditions at room temperature were 0.25 x105 L.mole-1 and 2.25x10-2 min-1 . The proposed method was successfully applied to the determination of sulfamerazine in synthetic samples of pharmaceutical formulation.

The conditions for the diazitization coupling reaction of thymol with 4-aminoantipyrine at p H in the presence of Triton X-100 were studies . The reaction gave an intense water soluble yellow product that hss a maximum absorption at 454 nm and Ԑmax of 1.966 × 104 L.mole-1.cm-1. A linear correlation (1-14μg ml) was found between absorbance at λmax and concentration . The results obtained are both precise (RSD was better than 1.9) and accurate (relative error was better than -2.5). The coloured product was found to be 1:1 thymol : 4-aminoantipyrine . The stability constant of the product at room temperature were 0.75 x104 L.mole-1 . The proposed method was successfully applied to the determination of thymol in synthetic samples and in lastarine antiseptic pharmaceutical formulation

قبول نشر بحث علمي جديد في مجلة سكوبس وسيتم النشر في كانون الثاني 2026