زهراء فتحي فليح شربة

Introduction: Dyslipidemia is one of the most common metabolic disorders. Vitamin D is one of the essential fat soluble vitamins which has many functions in the human body. Aim: The aim of this study was to evaluate the association between dyslipidemia and vitamin D deficiency. Materials and methods: This is a cross-sectional study which included 130 participants (58 males and 72 females) aged between 20-70 years and conducted between June 1 and October 30, 2020. The level of vitamin D was determined for each participant; we also measured the serum levels of cholesterol, triglyceride, high density lipoprotein, and low density lipoprotein. Results: There were 79 persons with vitamin D deficiency, 21 persons were vitamin D insufficient, and 10 - vitamin D sufficient. There were significant differences in the level of cholesterol, triglycerides, high-density and low-density lipoproteins according to the level of vitamin D. Conclusions: Deficiency of vitamin D has a negative impact on the levels of cholesterol, triglycerides, high-density and low-density lipoproteins.

The immune system is a complicated system; it is consisted from network of specialized organs, tissues, cells, proteins, and chemicals which it has the function to protect the host from various types of pathogens such as bacteria, virus, fungi, and parasite in addition to cancer cells. Antioxidants are defined as agents that can prevent the damage that is caused by free radicals through scavenging of them. They decrease the damage by neutralizing to the free radicals before they attack any of the cells and can prevent lipids, enzymes, proteins, carbohydrates, and DNA damage.

BACKGROUND: Chronic kidney disease (CKD), also called chronic kidney failure, is described as gradual loss of kidney function. CKD can progress to end-stage kidney failure, which is fatal without artificial filtering (dialysis) or kidney transplant. Peritoneal dialysis (PD) has a widespread renal replacement therapy with great acceptance because of simplicity, flexibility, and independence. AIM: The aim of this study was to evaluate the complications of continuous ambulatory PD (CAPD) in patients with CKD. METHODS: A cross-sectional study, involved 140 patients, aged between 18 and 80 years old and suffered from CKD under maintenance CAPD in the dialysis unit of the renal center. All data regarding the sociodemographic profile of the patient, vitals, etiological diagnosis, frequency and duration of dialysis, and dialysis-related complications were taken. RESULTS: In the current study, there is a significant difference in the distribution of complications among gender where the female patients had a higher incidence of both infectious and non-infectious complications. The study also reported that there is much lower rate of complications among patients on laparoscope operation in compared with the open operation. In addition, patients with open abdomen PD developed the complications earlier than those with laparoscope maintenance CAPD. CONCLUSION: Peritoneal infection is the most prevalent complication among the other complications in the current study. There is much lower rate of complications among patients on PD in compared with hemodialysis and on laparoscope in compared with the open operation.

Abstract This paper aims to test the correlation between the recovered cases of covid-19 and weather parameters in Baghdad city of Iraq, also estimated the importance weight values of each weather parameter and it is affected by recovered cases. The daily-recovered cases were obtained from reports of the Ministry of Health and Environment for the period (20 March to 24 July 2020). The daily weather parameters included maximum temperature, minimum temperature, average temperature, average humidity, maximum wind speed, minimum wind speed, and average wind speed. Based on each data distributions, the nonparametric method utilized to estimate the correlation between them. Spearman rank was used to conclude the very strong and strong correlation between the recovered covid-19 cases with temperature and humidity respectively. The relationship between the recovered cases and temperature was directly proportional while its relation inverse with humidity. The neural network techniques were applied to predict the importance of the weight values of each weather parameter and recovered cases. These outcomes researched to hope the increase of recovered cases with weather changes, but it is important to note that even if there is an influence of weather in any aspect during covid-19 pandemic all precautions must be taken and social distancing must be committed considering many confounding factors.

Objective: To survey K-RAS blocker of choice among a group of inhibitors with characterizing their safety profile in colorectal carcinoma. An experimental model of continuous SW480 cell line and Vero cell line was applied, in vitro assessment by using tissue culture as a standard technique for checking the cytotoxicity of many compounds and in development of new drugs. Materials and methods: This study tested the cytotoxicity assay of MEX2R and chemotherapy (methotrexate) as comparative agents in the mechanism of action with the tested drug by Crystal Violet assay (CV). After exposure both SW480 cell line and Vero cell line were treated first to different concentrations of MEX2R compound (15.625, 31.25, 62.5, 125, 250 and 500) μg/ml for 36 hours and secondly to different concentrations of methotrexate (15.625, 31.25, 62.5, 125, 250 and 500) μg/ml for 36 hours. Results: The results showed that the investigational agent MEX2R exhibits highly significant cytotoxic effects (p ≤ 0.05) in SW480 colorectal cancer cells when compared with control (untreated cells), and less cytotoxic influences on normal Vero cell line in a dose-dependent manner. The tested drugs showed anticancer activity with half maximal growth inhibitory concentrations (IC50) for MEX2R 65.738 μg/ml which was more potent than antitumor drugs methotrexate (MTX) that has cell cycle arrest activity like investigational agent’s action, IC50 of MTX was about 93.574 μg/ml. The selectivity index of MEX2R compound (3.252) was higher than the selectivity index of MTX (2.65). Conclusion: From the overall results, MEX2R has highly significant cytotoxic effects on SW480 colorectal cancer cell line when compared with MTX, also MEX2R agent possessed safe profiles in Vero cell line as normal cells in comparison with standard chemotherapy MTX.

Background: Wilms' tumor gene 1 (WT1), a tumor-associated antigen (TAA), is expressed in many types of cancer. Most acute leukemia patients have a quantitatively detectable and strong expression of it. Objectives: To analyze WT1 expression levels as a predictor of clinical outcomes at the time of diagnosis of de novo leukemia and to monitor tumor progression during treatment. Methods: A total of 71 patients with acute myeloid leukemia (AML) were separated into two groups: twenty-nine de novo AML patients upon presentation and 25 with AML at the time of initial induction. The second induction included 17 AML patients and ten healthy volunteers who served as controls in this study. The WT1 gene was tested using a real-time PCR with the Cyber Green assay. Results: Patients with acute myeloid leukemia had considerably greater levels of WT1 gene expression than controls (27.3 vs. 5.5). In terms of clinical outcomes, WT1 gene overexpression was substantially related to non-responsive AML patients compared to complete response at diagnosis (27.3 vs. 22.15). However, there is no substantial difference between instances following induction. Conclusions: The WT1 tumor antigen may serve as an early diagnostic for acute leukemia prognosis. Improved clinical outcomes have been linked to reduced WT1 levels. A high amount, on the other hand, was linked to a poor prognosis for people with AML, although more research is needed

تهدف الدورة إلى تدريب الصيدلاني على جميع التفاصيل التي قد لا يستطيع الاطلاع عليها أثناء التدريب لأي سبب،تلك التفاصيل التي تمكنه من العمل في الصيدلية بمهارة واحترافية، حتى وإن كان صيدلانيًا حديث التخرج. إذ تحتوي الدورة على شرح وافٍ وكامل لجميع المهارات التي يحتاجها أي صيدلاني لاستلام مهام الصيدلاني المسؤول سواء أكان مالكًا لصيدلية أو صيدلانيًا مسؤولًا فيها.

اقيمت الدورة بتاريخ 17/2/2022 ولمدة 5 ايام تضمنت مقدمة عامة عن الرعاية الصحية ودورها الفعال في المجتمع بالاضافة الى تعريع المشتركين بأهم المهارات الخاصة بالرعاية الصحية

تعريف الباحثين وطلبة الدراسات العليا بانواع الدراسات البحثية وكيفية اختيار نوع الدراسة الملائم للبحث

تضمنت الدورة تعريف المشتركين بطريقة عمل كل نوع من انواع اللقاحات المستخدمة لمرض كوفيد – 19 والفرق بينها من حيث طريقة تصنيعها وفعاليتها داخل الجسم وعدد الجرع اللازمة لكل نوع والمدة الفاصلة بين الجرع والفئات العمرية المناسبة لكل نوع و الاعراض الجانبية الممكن ظهورها بعد اخذ اللقاح واهم التساؤلات الشائعة عن لقاحات مرض كوفيد -19وتوضيح اهمية اخذ اللقاح للحد من انتشار المرض وحدوث المضاعفات نتيجة الاصابة بهذا الفايروس والتي قد تؤدي الى الوفاة في كثير من الاحيان

قاممجموعة من تدريسي فرع الادوية والسموم في كلية الصيدلة وباشراف مباشر من قبل عمادة الكلية بحملة توعية حول هذا المرض بعمل مجموعة من البوسترات التعريفية عن المرض وطرق الوقاية منه بتاريخ 4/5/2020 وتم تثبيتها في جميع بوابات جامعة الكوفة ومدينة الصدر الطبية ومديرية دائرة الصحة ومركز النجف لجراحة القلب

ضمن النشاطات الطلابية اللاصفية قام عدد من تدريسيو الكلية وبمشاركة مجموعة من طلبة الكلية بتحضير كمية من الكحول الاثيلي والجل الطبي المعقم بالاعتماد على الجهود الذاتية والاجهزة المختبرية في الكلية تحت اشراف السيد العميد ومعاونوة المحترمون. وقد تم التبرع بكمية من المواد المحضرة الى دائرة صحة النجف اضافة الى فروع الكلية وبعض كليات الجامعة. ضمن النشاطات الطلابية اللاصفية قام عدد من تدريسيو الكلية وبمشاركة مجموعة من طلبة الكلية بتحضير كمية من الكحول الاثيلي والجل الطبي المعقم بالاعتماد على الجهود الذاتية والاجهزة المختبرية في الكلية تحت اشراف السيد العميد ومعاونوة المحترمون. وقد تم التبرع بكمية من المواد المحضرة الى دائرة صحة النجف اضافة الى فروع الكلية وبعض كليات الجامعة.