Synthesis and Biological activity Study of new azo dyes 1-[(2,4-Dimethylphenyl)azo]-2-naphthol ( DMPAN ) And 1-[(2,4-Dichlorophenyl)azo]-2-naphthol ( DCPAN )
The work presented in this study contained preparation and characterization of new azo compound 1-[(2,4-Dimethylphenyl) azo]-2- naphthol (DMPAN) and 1-[(2,4 – Dichlorophenyl) azo] -2- naphthol( DCPAN) from reaction of aniline derivative ( 2,4 - Dimethyl aniline ) and ( 2,4 - Dichloro aniline) after azofcation with derivative of naphthalene ( 2- naphthol ) . These ligand has been identified by the known spectral methods Fourier Transform Infra Red ( FT-IR) , Ultra violate ( Uv – Visb ) . In addition of calculate the percent of element carbon , hydrogen and nitrogen C.H.N and compared with experimental results . The biological activity of compounds (DMPAN) and ( DCPAN) against four types of bacteria(Staph.aureus) as example of gram positive, (Esherichia Coli , proteus mirabilis , Klebsiella pneumonias) example of gram negative bacteria was studied. The result of biological study were compared with the known medical compounds (Cerftriaxon) and (Clarithromycin) the tow compound was weekly active against all pacteria Species tested .