PHYSIOLOGICAL AND BIOCHEMICAL EFFECTS STUDY ON AQUEOUS EXTRACT OF THYMUS VULGARIS IN ALLOXAN INDUCED DIABETIC MALE ALBINO RATS
Diabetes mellitus is metabolic disease due to hyperglycemia result from insufficient insulin inability of insulin secretion, sensitivity that lead to loss of glucose homeostasis. DM can affect in every organ system in the human body. Thirty adult male albino rats weighing 150-200 g, five adult male albino rats were divided into 5 experimental groups. The result showed a significantly increased (p< 0.05) in sugar, creatinine urea and uric acid in group that inject with alloxan when compared with control group (thymus + alloxan) and (thymus only) and (thymus + Glimepiride) groups that showed significantly decreased (p< 0.05) due to presence of polyphenols and flavonoids in thyme that responsible for the antioxidant. While, the total protein significantly decreased (p< 0.05) in alloxan group when compare with control. Also showing significantly decreased (p> 0.05) in WBC, RBC, HB and platelet in diabetic rats, but when use Thymus vulgaris that showed significantly increase in (WBC, RBC, HB platelet).