رؤى حميد حسن الواعظ

الوصف Breast cancer is the most common type of cancer among women and one of the main causes of death, especially in the premenopausal age group. The aim of study was to estimate serum LDH, GGT, ALP levels and CA15-3 in 160 breast cancer patients at pre-and post-menopausal, who had at least 3 chemotherapy sessions and estimating levels of these markers at different stages of the disease, also, study their relationship with CA15-3. WBC, ANC, PLT, NLR, PLR, and ESR levels were significantly increased, while ALC, MPV and RBC were significantly decrease in breast cancer patients compared with control (P<. 01). No significant differences were observed in NLR, PLR and MPV levels regarding age (P>. 05). Serum LDH, GGT, ALP levels and tumor marker CA15-3 were significantly higher in pre and postmenopausal breast cancer patients compared with control (p<. 001). Postmenopausal patients had higher LDH and ALP levels and a significant decrease in GGT level and CA15-3 compared with premenopausal women (p<. 001). Pearson correlation coefficient showed the positive correlation of serum LDH vs. ALP (r=. 1017), LDH vs. GGT (r=. 7110) and CA153 vs. GGT (r=. 7131), while the relationship is reverse of GGT vs. ALP (r=-. 2103), CA15-3 vs. LDH (r=-. 3110) and CA15-3 vs. ALP (r=-. 5331) in postmenopausal patients. NLR and PLR levels were significantly higher in patients at stage IV compared to other stages (p<. 01). MPV level was significantly higher in patients at stage I compared to other stages (p<. 01). Serum LDH, GGT, ALP levels and CA15-3 were significantly higher in patients at stage

objectives: To study the sensitivity of Chromogranin A in the diagnosis of neuroendocrine tumors from various locations in the body and its association with clinicopathological parameters like site and grade of tumors . methodology: This study is conducted in the Department of Pathology, Faculty of Medicine, University of Kufa from January - October 2013. A total of 50 patients with neuroendocrine tumors from different locations. their ages ranging between 22-80 years with a mean age of 48.3 years. Two step Envision TM flex method was employed forimmunohistochemical detection of ki67 antigen (MIB -1) and Chromogranin A . Results: Main site for patients with neuroendocrine tumors included in this study is gastroenteropancreatic system and there is female predominance , from 50 patients 44 (88%) cases was positive for Chromoranin A expression , there was no significant differences in expression of the Chromogranin A with location and grade of tumors (P value >0.05) Conclusion: Chromogranin A is highly sensitive marker in diagnosis of neuroendocrine tumors irrespective to tumors location and tumor grade . Recommendation: We advise to use Chromogranin A immunohistochemical marker as a main marker in diagnosis of neuroendocrie tumors in addition to that this marker can be used as target for new modality in tumor therapy

Objective: examine the effect of CNTNAP2 gene polymorphism on behavioral therapy response in Iraqi children with autism spectrum disorder using ABLLS-r. Methods: In this study, 150 samples for autism spectrum disorder were obtained from AL-SIBTEIN ACADEMY, however owing to many challenges, the final number of samples was 50 patients. Polymerase Chain Reaction-Restriction refers to a technique that combines the use of polymerase chain reaction (PCR) with restriction enzymes to amplify and analyze certain DNA sequences. Fragment Length Polymorphism (PCR-RFLP) was used to genotype the CNTNAP2 gene at rs7794745. All 25 ABLLS-R repertoires and all four primary components had their dependent parameters determined by aggregating and converting the ABLLS data to a percentage. This provided us with the proportion of finished assignments from each repertoire. Results: After correlating the genotype data (AA/AT/TT) with the behavioral therapy response as indicated by ABLLS-R, we only discovered a statistically significant difference between the frequency of AA/TT genotypes in the rs7794745 variant in patients and the social interaction domain. Conversely, the remaining 24 subdomains exhibited no discernible correlation. Conclusion: This research topic could provide significant information on targeting and categorizing which skill areas need to be developed based on genetic models' influence.

Abstract Background: colorectal cancer is most common cancer types that recorded in highly incidence in last decade in Iraq, multifactor have implicated in disease progressing and development, some un translated regions implicated indirectly with disease, The current study aims to detect Association the UTR of IL-23 Receptor Variations with some Adenocarcinoma histological Features. Methods: a case control study was implemented using PCR-sequencing of UTR of IL-23 receptor gene, three SNPs were targeting in current study included (rs185937924 A>G, rs1653126126G>C and rs1300405558 T>A) Results: the results showed that deletion mutation observed in these SNPs, there were non-significant increases in deletion mutation in patients than control group (P=0.0983), the first SNP rs185937924 A>G shows non-significant association with adenocarcinoma (P= 0.247) for AA genotype and for AG and GG genotypes (P= 0.7353). Significant association of allele frequency was observed (P=0.0457). A new allele were recorded in current study for rs1653126126 (G>A), non-significant associated with disease in all genotyping for AG (P=0.3588) and for AA (P=0.4049), allele frequency also non-significant association with disease. a new allele also was observed in rs1300405558 (T>G), the genotyping showed non-significant association with disease TG was (P=0.5554), (P=0.5288) for TT, and GG (P=0.5552), all alleles frequencies were non-significant association. Belong to tumor differentiated the target SNPs genotyping didn’t associate with well or moderate differentiation, target SNPs didn’t showed significant relations with tumor staging and T. conclusion: from these results can be concluded that the IL-23 receptor variation in adenocarcinoma have a new alleles in study population (case and control) in the rs1653126126G>C (G>A) and rs1300405558 T<A (T<G), the new alleles didn’t associate with adenocarcinoma and with the histological features