رنا نعمة عطيه النداوي

Pyrimidine has been mentioned to present diverse biological activities such as antioxidant, anti-inflammatory, anti-tubercular, anti-bacterial, in additional to another biological activities, therefore, many medicine containing pyrimidine moiety have been observed. Due to the pharmacological importance of pyrimidine derivatives, the present work coms as attempt to synthesis of various pyrimidine derivatives by series of steps starting from chalcone, compounds (1 and 2) which were prepared by CliesenSchemidt condensation of acetophenone with (4-bromobenzaldehyde or 4-chlorobenzaldehyde). Then cyclization of compounds (1 or 2) with urea or thiourea to produce compounds (3 or 4 respectively). by another way, compound (1) was cyclized with thiourea to produce 4,5-Dihydropyrimidine-2(3H)-thione compound (5) which could be reacted with 3-cyanobenzyl chloride or benzyl chloride to give 2-Arylalkylthio-2,5-dihydropyrimidine derivatives compounds (6 or 7, respectively). These target compounds were confirmed on the basis FT-IR, and 1 H-NMR techniques. The biological study was evaluated against tow bacterial (Staphylococcus aureus as gram positive) and (Klebsiella pneumonia as gram negative) in concentration (50 and 100) μg/mL. It was found that derivatives have biological activity against growth these bacterial.

Nicotinic acid is one of the most important vitamins, which is involved in many vital processes within the bodies of living organisms, and its deficiency leads to many diseases, the most famous of which is barbaric disease. Nicotine acid has been used for many years as co-agent to reduce high levels of fats in the blood, but undesirable side effects have limited its use. On the contrary, nicotinic acid derivatives have shown high efficacy in treating many diseases such as pneumonia and kidney diseases, some derivatives have proven effective against Alzheimer's disease, and favorable researches were proved his activity.

A serious 1,2,3-triazole derivatives were prepared by reaction between4-azido-N-(5-methylisoxazol-3-yl)benzene sulfonamide with different triple bond derivatives in presence CuCl and sodium ascorbate as catalyst. FTIR, and NMR have established the chemical structures of the target compounds. All end derivatives were evaluated to in vitro antifungal testing against two types of fungi (Aspergillus niger and Candida albicans) and antibacterial screening against four pathogenic strains (Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus epidermidis, Escherichia coli). The findings indicate that the compounds being tested displayed promising activity and warranted further consideration as potential anti-micro bales.

Schiff bases are imine or azomethine-containing aldehydes or ketone-like compounds replacing the group carbonyl. They're widely utilized in industry, and they come in a variety range of biological processes. It has a wide Antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic characteristics are among the biological activities., and is commonly used in industry. Many Schiff bases complexes had high thermal and moisture stabilities, which were advantageous for their use as catalysts in high-temperature reactions. Because complexation generally increases activity, it's important to have a better understanding of the characteristics of both ligands. Medicinal chemists are now interested in developing Schiff bases and their metal complexes are novel chemotherapeutic Schiff bases. This is a review of gathers Schiff bases and complexes that have shown to be the most promising in various fields

This review described triazole and tetrazole (five-ring), these are heterocyclic aromatic five-ring compounds consisting of (two carbon atoms and three nitrogen atoms in triazole) while (four nitrogen atoms with one carbon atom in terazole), and they exist in three different formulas with different locations of heterogeneous atoms in the ring. These compounds were distinguished by a high efficiency towards microorganisms and microbes and have wide importance in the field of biochemistry and are considered a basic nucleus in many compounds Life as well in pharmacological drugs, and the present list included a review of the different methods of preparation for the components of triazole and tetrazole as well as their applications in several areas.

A number of modified pyrimidines can also be found in both DNA and RNA. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. They have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, antimalaria medication, drugs for treating high blood pressure, and HIV medication. The nucleotides can be altered through oxidation, methylation, amination., This study was involved synthesis of new 2-Arylakylthio-5-halo-4- methyl pyrimidine-6(1H)-one derivatives. The structure of the target compounds were confirmed via (FT-IR, 1HNMR and GCMS Spectrometry). The biological activity of the synthesized compound (3) as Anticancer agent with the results indicated a highly inhibitory activity at a highly concentration (100 µg/ml) on MCF-7 cell is 72.3, IC50= 25.67 while the highly inhibitory activity of synthesized compound at highly concentration (100 µg/ml) on normal cell (Rat Embryo Fibroblast) is 11.3 with good performance

تهدف الورشة الى التطرق لتطبيقات الاشعة تحت الحمراء في مجالات التشخيص حيث يتم تأكيد تحضير المركبات العضوية وغيرها بالاعتماد على التغيرات التي تحدث بترددات المجاميع الوظيفية لذلك تعتبر احد اهم التحاليل اللازمة في اثبات حدوث التفاعلات من خلال اختفاء وظهور وتغير ترددات المجاميع الفعالة

2021

الرنين النووي المغناطيسي الاشعة تحن الحمراء