رجاء عبد الامير غافل الحدراوي

This paper involves synthesized of some heterocyclic compounds derivatives by using Meldrum’s Acid as starting material by Multicomponent reaction of Meldrum’s Acid, salisaldehyde and indol, Meldrum acid derivative, which further to synthesis Schiff base derivative after that Schiff base using to prepare of four, five, seven membered ring by reacted with different materials. Their structures were identified by (FT-IR, 1HNMR, 1CNMR). The synthetic compounds were screened in vitro antimicrobial for biological activity

This paper involves synthesis of some heterocyclic compound derivative from Meldrum's acid ,by reaction of Meldrum's acid , indol and p-hydroxy benzaldehyde and catalyst L-proline in aceto nitrile to produce Meldrum's acid derivative (P),compound (P) ethanolysis to give ester derivative (P1),the compound (P1) reacted with hydrazine hydrate to give hydrazide derivative compound (P2) ,hydrazide derivative reacted with p-hydroxy benzaldehyde in absolute ethanol to give Schiff base derivative(P3),shiff base derivative using to prepare some new heterocyclic compounds by multi step reactions and reactant with different solvent and materials to prepare four ,five and seven ring membered . The prepared compounds were characterized by FT-IR ,H1NMR,13CNMR .All the prepared compounds were studied the antibacterial activity.

2018

2018

تمت مناقشتي للحصول على شهادة الدكتوراة في الكمياء العضويه في كلية التربية للبنات