رضية عبد الباقي خضر الدجيلي

Our work aimed for organic synthesis and biological investigation of some new heterocyclic derivatives by three steps : the first step included synthesis of some five-membered and six-membered heterocyclic derivatives (Pyrazole, Isoxazole, Oxazine and Thiazine) from Chalcone. The second step included synthesis of some 1,3-Oxazipene derivatives from Schiff’s bases derived from Azo compound. The third step included the assay of biological activity of all compounds against four types of pathogens bacteria (Staphylococcus aureus, Granutice tella adiacens) gram positive and ( E. coli, Proteus mirabilis) gram negative the results exhibited excellent biological activity for all derivatives compared to antibiotics (Ampicillin and Ciprofloxacin). These compounds were identified and confirmed by FT- IR, 1HNMR, 13CNMR and elemental analysis.

Abstract Series sulfur and nitrogen organic compounds were prepared in our previously paper(1), which act various compounds ( thia, sulfur, aze, sulfide ) from halogenation reaction ,condensation reaction, cyclization reaction . The synthesized compounds have been studied ((chromatography behavior , DSC- thermal measurements)) for stability of compounds , studying of physical and other analytical studies like solubility in various solvents )) , then tested in microbial

This paper involved synthesis of series from macro compounds through reaction between di carbonyl compounds like (cyclo hexane-1,3-dione., 1,3-diphenyl–propadione, acetyl acetone, maleic anhydride, maleic acid, malonic acid) with di amine compounds or thiophene compound to produce compounds [1-5 ,7, 8,11], which reacted with azo compound, benzaldehyde, via alkylation reaction and azotation reaction to yield compounds [6,9,10,12] .The structure of these compounds were characterized by (H.NMR, FT.IR, C.H.N–analysis) techniques and their melting points.

Chalcones are starting compounds in synthesis of heterocycles containing di nitrogen atoms which named (di aze) , an attempt to synthesis of chalcones from acetanilide with aromatic aldehydes such as P-N,N-dimethyl benzaldehyde and P-hydroxy benzaldehyde by Claisen- Schmidt condensation.The resulting chalcones after purification have been converted into substituted pyrazoline and pyrimidine by reaction with hydrazine hydrate,urea,thiourea and guanidine.All these compounds were characterized by Physical and spectral methods such as melting point, FT-IR,HNMR and C.H.N analysis.

تم تحضير عدد من المركبات الحلقية الغير متجانسة من قاعدة شف جديدة محضرة 2-امينو(2-ايمين فيوران)

synthesis of new organic compounds (azitidine, tetrazole, oxazepine, diazepine, thio compound, amide compound) which some of them have cyclic structure(four, five, seven)-membered ring. All synthesized compounds[1-10] characterized by chemical techniques (FT-IR,H1-NMR, C.H.N-analysis) and melting points

there are usually one or more substantial projects undertaken in the fourth-year, which may well have research elements. At the end of the second or third years, there is usually a threshold of academic performance in examinations to be reached to allow progression into the final year.

The new tetra azo methine macrocyclic ligand[ ( 9E)-11-((Z)-(5-chloro-2-methyl phenyl) diazenyl )-7,8,10,12,14,15-hexa methyl -6,16- diphenyl-7,11,15,16-tetrahydro-6H-benzo[e]diPyrazolo[4,3-3,4-h][1,4,7,10]tetra azo cyclotride cine] has been synthesized from condensation of (3-[5-chloro-2-methyl phenyl azo]-2,4 di( imino-4-antipyrineyl) pentane) with o-phenylene diamine. Monomeric complexes with the general formula [M(L)]Cl2 Wher. M= Co(II) , Ni (II), Cu (II) and Zn(II) are reported. The Structures of new ligand , mode of bonding and over all geome try of the complexes were determined through IR, UV-Vis, and1 H NMR spectral studies, magnetic moment measurement, elemental analysis, metal content, and molar conductance.These studies revealed squar planaer geometries for all complexes. Complex formation studies via molar ratio and continuous variation .methods were consisted to those found in the solid complexes with a ratio of ( M:L) as (1:1) . Stabitity constant of complexes were calculated by spectro photometricaly. Hyper Chem-8 program has been used to predict structural geometries of compounds in gas phase. The heat of formation (ΔHf) and binding energy (ΔE b) at 298 K for the metal complexes was calculated by PM3 method. Biological activity studies of the ligand and its metal complexes against several organisms , staphylococcus aureus, Esherichia coli, Klebsilla, Aspegills niger, Aspegills flavus are reported . Compounds exhibited the high effect of activity. This may be attributed to the impact of both the chelate effect o f macro cyclic Schiff bases ligand and the role of the metal in these complexes. Key Words: Synthesis tetra dentate macrocyclic ligand, Characterization, Biological activity

This research involved synthesis of new β-Lactam derivative from Azo compound[4-amino-N-(pyrimidine-2-yl)-3-(pyrimidine-2-yldiazenyl) benzene sulfonamide] (S1) record previously by many steps. Starting conversion the free amino group in an azo comp. to chloro acetamide derivative(S2), then reacted it with urea to give the oxazole ring derivative (S3) that which containing free amino group. The condensation reaction between the amino group and P-bromobenzaldehyde to produce Shiff base (B14). Finally staudinger's cyclo addition reaction go run between the Shiff base derivative (B14) and chloro acetyl chloride in the presence of tri ethyl amine (Et3N) as Base catalyst and dioxane as solvent at 5-10oC to give β-Lactam derivative (L14). Most of these derivatives were confirmed by "FT-IR, 1HNMR and CNMR" spectra.

This paper involves synthesis new Mannich bases derived from Shiff' bases which prepared from isatin by the reaction of isatin with different aromatic amines to prepare Shiff bases derivatives (M, G, B, R, X, S), then Shiff's bases derivatives reacted with formaldehyde and piperazine to produce Mannich bases derivatives (M1, G1, B1, R1, X1, S1). The third step included the assay of biological activity of all compounds against four types of pathogens bacteria (staphylococcus aureus, Granutice tella adiacens) gram positive and (E. coli, Proteus mirabilis) gram negative the results exhibited excellent biological activity for all derivatives compared to antibiotics (Ampicillin and Ciprofloxacin) these structures were identified by FT-IR, 1HNMRand 13CNMR.

In this work new different hetero cyclic derivatives were synthesized that which including β-Lactam, teterazole and also thiazole rings.The starting material is 2-amino-6-methoxy-Benzothiazole. All these reactions follow by (TLC) and Measurement melting points for some of these derivatives. The compounds identified by FT-IR and some of them by 1H-NMR and 13C-NMR spectra., The prepared benzothiazole derivatives in this study gave good results through appearance of new bands and disapearance of other bands in formatted compounds that gave first data to formation benzothiazole derivative , while second technique represented by resonance spectra that gave also good results for formatted benzothiazole derivative.m in addition to flowing of all reactions by paper chromatography.