نورالهدى غانم هادي الفتلاوي

Background :- Graves’ disease (GD) is an autoimmune disorder specific for thyroid gland causes overactive thyroid . B-cell activating factor (BAFF) of TNF family is cytokines which responsible on important a role for regulating B lymphocytes proliferation and survival . Increase level this cytokines within currency used to be celebrated of a number of kinds on autoimmune diseases . There had been no reviews focusing over the potent relationship among the activity of newly diagnosed of GD and BAFF . To discover the pathophysiologic function over BAFF of GD we investigated serum level of BAFF in sufferers with GD. Methods :- We managed fifty patients newly identified as GD and twenty five as healthy controls. We measured BAFF level in serum levels by ELISA , thyroid stimulated hormone and thyroid hormone by VIDAS in both controls and GD patients. Results :- BAFF serum level was significantly elevated in sufferers along GD compared than controls (1237.41± 71.79 pg/mL vs. 537.33±48.71pg/ mL ,P< 0.05) . The serum BAFF level was considerably related to with T3 and T4 , a helpful indicator for the activity of GD. Conclusions :- We conclude that BAFF concentrations are increased in GD patients, is based on pathophysiological of B-cell-driven mechanism not depended on the age and BMI but BAFF level are higher significantly in females than males .

Multiple cysts on ovarian condition it is one of the generality hormonal troubles in adult females of generative prong give rise to unequal menstrual peroid, immoderate in frame or in facial hair, termination as well as sterility. Concerning 80% of adult female accompanied by multiple cysts on ovarian endure from menstrual dysfunction (oligo- menorrhea, an abnormal absence of menstruation) during several mark in their sexual life and in this study (regular and irregular menstrual cycle). Regular menstrual cycle (middle extent of the menstrual cycle amidst 22 and 41 days. Either none or extreme of 1 menstrual peroids with length<22 or>41 days through the former year. Irregular cycle (middle extent of the menstrual cycle admist 22 and 41 days. Two or more menstrual peroids with length<22 or>41 days through the former year. Multiple cysts on ovarian condition is a sex hormone disorders that can influence on marital satisfaction of affected married women. The objectives of this study is assessing the levels of LH hormone according to menstrual cycle state, marital state and height. method :37adult female were diagnosed with multiple cysts on ovarian condition and19 control women recruited from Abbas AL-Nafakh laboratory in AL-Najaf AL-Ashraf city during the period from4\1\2021to9\3\2021. Patients with multiple cysts on ovarian condition were divided into groups according to menstrual cycle (regular and irregular group), marital state (married and unmarried) and height. Results: the results of this study revealed a significant increase (P<0. 05) in LH hormone level in adult female with multiple cysts on ovarian condition in comparing with control group. This treatise also showed a significant difference (P<0. 05) in LH hormone level between regular and irregular group in women with multiple cysts on ovarian condition. Also, in this treatis this results also suggest no significant variances (P>0. 05) between married group and unmarried group in adult female with multiple cysts on ovarian condition and also there no significant variances (P>0. 05) between wedded and unwed group in control women, while it was found a significant variances (P<0. 05) in wedded group between patients and control women and also it was found a significant difference (P<0. 05) in unmarried group between patients and control women. Finally the present study have been shown positive correlation (P<0. 05) between LH hormone level and height in women with multiple cysts on ovarian condition.

Thrombocytopenia may be a reduction in circulating platelet counts. Primary thrombocytopenia or idiopathic thrombocytopenia purpura (lTP) is an autoimmune disorder of unknown condition and thrombocytopenia that a result of a known condition called secondary thrombocytopenia. FCGR llb is sort of Fc gamma receptors FcgRs are receptors for (IgG), FcyRIIb is that the only inhibitory FcyR who particularly expressed about B-cells. FcgR llb move vital roles in pathophysiology regarding the many autoimmune disorder like thrombocytopenia. The study was applied on 85 people aged 20 to 69 year; 65 patients' group with thrombocytopenia and 30 healthy group as a control group in Holy-Najaf. The group of patients was divided into subgroups based on gender, age, body mass index (BMl), primary and secondary thrombocytopenia. The complete blood count was examined for all patients group and healthy group. FCGR llb serum level was significantly decrease (P< 0.05) in thrombocytopenia patients compared than controls. Primary thrombocytopenia shows significant decrease (P< 0.05) in FCGR llb serum than secondary thrombocytopenia. The results exhibited non a significant increase (P>0.05) in serum FCGR level in female patients group compared with male patients' group. Also the results indicated non-significant differences (P>0.05) in serum FCGR llb level of patients at different ages group and different types of body mass index (normal weight, over weight and obese weight) respectively The results of correlation and linear regression indicated significant positive correlation (P< 0.05) between FCGR llb and platelets concentrations and non-significant negative (P>0.05) correlation between FCGR llb and leucocyte counts in primary thrombocytopenia while non-significant positive correlation between FCGR llb and platelets concentrations and a significant positive correlation (P<0.05) between FCGR llb and leucocytes counts of secondary thrombocytopenia. The serum FCGR llb level was considerably related with platelets counts in lTP so a useful indicator for lTP.

Thrombocytopenia is a reduction in circulating platelet levels. Primary thrombocytopenia or idiopathic or immune thrombocytopenia purpura (ITP) is an autoimmune disorder of unknown cause affecting both children and adults and thrombocytopenia that a result from a known condition is called secondary thrombocytopenia. The B-Cell-Activating Factor (BAFF) belonging to the tumor necrosis factor (TNF) superfamily are key actors for the B-cell survival then the immune responses concerning mature B-cells, BAFF and APRIL are concerned of the pathogenesis of a variety of human autoimmune diseases. To discover the pathophysiologic characteristic concerning BAFF within thrombocytopenia we investigated serum level of BAFF ITP and secondary thrombocytopenia. The study was applied on 85 people aged 20 to 69 year; 65 patients group with thrombocytopenia and 30 healthy group as a control group. The group of patients was divided into subgroups based on gender, age, body mass index (BMI), primary and secondary thrombocytopenia. The complete blood count were examined for all patients group and healthy group. BAFF serum level was significantly decrease (P<0.05) in thrombocytopenia patients than controls. Primary thrombocytopenia show non-significant decrease (P>0.05) in BAFF serum compare with secondary thrombocytopenia. The results exhibited non a significant increase (P>0.05) in serum BAFF level in female compared with male thrombocytopenia patients and indicated non-significant differences (P>0.05) in serum BAFF level of patients at different ages group and different types of body mass index (normal weight, over weight and obese weight) respectively. The results of correlation and linear regression indicated a significant negative (P<0.05) correlation between BAFF and platelets and significant positive(P<0.05) correlation between BAFF and leucocytes counts in primary thrombocytopenia, while significant positive(P<0.05) correlation between BAFF and platelets concentrations and non-significant positive (P>0.05) correlation BAFF and leucocytes counts in secondary thrombocytopenia. Current study was aimed to determine BAFF which can be used for diagnosis and prognosis of ITP

The search of new pramrters for monitoring and even prediction of diabetes mellitus (DM) are still an important issue in many research fields .Some studies focused on role of insulin status ,while others concentrated on lipid disturbances or even oxidative stress disorders in the diabetes. The study was conducted by taking 66 type 2 diabetic patients (NIDDM) (32males and 34 females) attending the diabetes mellitus center in Al-Sadder Teaching City in Al- Najaf province and a group of 21 apparently healthy subjects ( 9 Males and 12 Females) were included as a control group. The study was carried out from August 2012 to February 2013. The age of patients and control groups were range of 35-65 y. The concentration of fasting blood glucose (FBG), cholesterol ,triglyceride (TG),HDL ,leptin and vitamin C were measured ,also VLDL ,LDL and BMI were estimated in patients and the control groups. The results show significant decrease (p<0.05) leptin ,vitamin C and HDL levels in patients compared with control groups , also the results show significant increase (p<0.05) in FBG ,cholesterol ,TG,LDL and VLDL levels in patients compared with control groups. The results have been shown significant negative correlation (p<0.05) among leptin with FBG and HDL in patients. The results have been shown significant positive correlation (p<0.05) among leptin with cholesterol , TG, LDL and VLDL in patients. Also the results have been shown non significant correlation (p<0.05) between leptin and vitamin C in patients. The present study concluded that leptin and vitamin C levels were a markers for detection and diagnosis of diabetic patients type 2.

Abstract Objective: To determine the correlation between toll-like receptor 4 and cytotoxic T cells in patients with type-1 diabetes mellitus. Method: The cross-sectional, case control study was conducted at Al-Manatharah Hospital in the Al-Najaf province of Iraq from June 2021 to December 2021, and comprised patients of either gender aged 20-69 years having type-1 diabetes mellitus in group A, and healthy subjects in control group B. From all the subjects, 4ml blood was collected by vein puncture. Fasting blood glucose and lipid profile were estimated using a precipitant kit. Also measured were toll-like receptor 4 and cytotoxic T cell levels using an enzyme-linked immunosorbent assay kit. Data was also noted on age, gender and body mass index. Data was analysed using SPSS version 23 Results: Of the 100 subjects, 60(60%) were cases; 30(50%) males and as many females with mean age 59.21±18.092 years. The remaining 40(40%) were controls; 20(50%) males and as many females with mean age 42.076±11.019 years. BMI values were not significantly different between the groups (p>0.05), and all lipid profile values were significantly higher in group A compared to group B (p<0.05) except high-density lipoprotein which was higher in group B compared to group A (p<0.05). Group A patients had significantly higher levels of toll-like receptor 4 and cytotoxic T cell than group B subjects (p<0.05). Conclusion: A significant relationship was found between type-1 diabetes and higher levels of toll-like receptor 4 and cytotoxic T cells. Keywords: Diabetes mellitus, Toll-like receptor 4, Cytotoxic T cells, CD8.

تاثير مستحضرات التجميل على صحة الانسان مع استمرار الاستخدام تم اقامه ندوه بعنوان تاثير المستحضرات الكيمياويه على الصحة الجسميه بالتعاون مع شركة سيباميد وشركة سكن لاب وشركة ازز فارمه