ميثاق عبد الرزاق عزيز الشمخي

Gabapentin (GPN) is an anti-seizure drug that has also been e, prescribed for managing nerve pain and other ailments. However, its abuse has become an increasing concern, as it might lead to a serious health hazard. This study was therefore conducted to investigate the effects of oral administration of GPN drug on hematological blood parameters, as well as examine histological changes in vital organs of laboratory mice. Twenty female mice were obtained for the study and divided into four groups (5 mice each). The control group (G1) was maintained on a standard ration and treated orally with 1 ml of distilled water. Treatment groups; G2, G3, and G4 were administered with GPN (1, 0.5, and 0.25 mg/kg body weight, respectively) for 8 weeks. At the end of the experiment, the animals were sacrificed and the blood was collected for hematological analysis and histological examination on the liver and kidney. The results revealed that in the GPN-treated G2 (1 mg/kg body weight), a significant (p<0.05) decrease in WBC count was observed compared with the control group (G1), but the differences among the other groups were not significant. There was a significant decrease in the RBC, MCV, and MCH values, compared to the G1. Conversely, RDW, PLT, liver enzyme function and kidney parameters in all the GPN-treated groups (G2, G3, and G4) increased significantly in relation to the G1. Furthermore, the pathohistological study revealed extensive damage to the liver tissues and hepatocyte cord in the G2; moderate damage in the G3; while no obvious change was observed in the G4. Our findings indicated that the use of GPN as an anti-arthritis drug at high doses is associated with a long-term wide range of side effects in the body, and its use is therefore recommended at lower doses.

The contemporary revision was accompanied at Al-Zahraa-Teaching -Hospital for Obstetrics. This research comprised a histo-pathological study of women distress from cluster pregnancy in Najaf Governorate, who reviewed the obstetrics department at Al-Zahraa-Teaching-Hospital for the period from 1/9/2017 to 5/2/2018.About (10) of women with cluster pregnancies, (5) cases of complete cluster pregnancies and (5) cases of partial cluster pregnancy. The range age of women with cluster pregnancies ranged from (25-15) y. The consequences of the anatomical and histological revision of women with cluster pregnancy showed that there were two types of cluster pregnancies: full cluster pregnancy and partial cluster pregnancy. Also revealed that the placenta and the fetus looked as a block on the fluid filled bags analogous to the grape cluster where the size of these bags about (8 * 8). It was also distinguished that the fetus and placenta were not distinctive in a clear and completely slanted. However the results indicated for women with partial cluster pregnancy that the fetus and a bulky partition of the placenta appeared in the form of a mass container on the bags filled with liquids, which were in the form of irregular clusters similar to the cluster of grapes, where the size of these bags about (5 * 5) .As noted that the fetus completely mutilated or non-existent but a minor portion of the placenta lingered intact and distinctive.

The hypolipidemicactivity of aqueous extract for flowers of Hibiscussabdariffa L. was evaluated inhypercholesterolemicrats.Thirty two male adult rats were divided into four groups, each one involved eight rats. First group fed normal diet (normal group). The second group fed with high cholesterol diet (HCD) and received oral administration of 2 ml sterile water (control group). the third and fourth groups fed with high cholesterol diet(HCD) and received oral administration of aqueous extract of flowers of H. sabdariffa, 200 and 400 mg/kg respectively in 2 mL of sterile water for 21 days. The animals were sacrificed; Biochemical analysis of blood serum were performed for lipid profile and liver enzymes.The extract induces a significant decrease in serum cholesterol, triglycerides and Bloodlevels of AST, ALT, ALP. The results concluded that Hibiscus sabdariffaextract aqueous (200, 400 mg/kg) have potent hypolipidemicactivity inhypercholesterolemic rats.

One hundred patient were agonized from anemia in the Najaf city (AL-Zahraa hospital ) the current revision was conducted out on the patient child at age was alternated from one year to twelve year during the period from january2015 extended to December 2015 .This study was ensured the type of the anemia infected to the patient child and , and determine the relation between the anemia , age, gender, and blood parameter (Hb, Pcv, and WBC) and investigation of blood films to detect the morphological change in the RBC . The consequence was exposed, male child percent infected with anemia (58%) and female percent was (42%) . the high percent (44%) of the anemic child at age (one- three) years the common types of anemia and involve the iron deficiency at percent (54%) . There was negative non significance difference between types of anemia and the leukocyte count .The result was appeared decrease in the hemoglobin% and type of anemia that found significant value between anemia and Hb and Pcv.

This study was aimed to survey the number of congenital malformation in Najaf province throughout all data which be collected from hospital (age; sex; blood group; kind of delivery; weight neonates).

The cross comparative present study was conducted out on the hundred patients were suffered from hyperthyroidism in the hospitals of four governments (Karbala, Babylon, Dywania and Najaf). This work was extend from September (2014) to fibruary (2015), which involved both females and males at ages were ranged (15-70) year old. The preset study was designed to identify the relationship among hyperthyroidism and many factors such as hormonal, mineral, liver enzyme, albumin, globulin and total protein. Our findings in all govrnments were investigated the feale patients with hyperthyroidism had more percent, in Karbala(76%) , Babylon (68%), Dywania (68%) and Najaf (68%) when compared with male patients percent (32% in Dywanian, Babylon and Najaf) while in Karbala was (24%). The age factor was noticed, that the age group (26-40) years were exposed to hyperthyroidism in both females and males. Thyroid gland Also the present study was pointed at variance in the mineral (calcium, potassium and phosphor), total protein and liver enzyme (Got and GPT) with hormonal assay (T3 , T4, TSH) in the biostatical analysis, such as person correlation and P value. As well as this cross comparative study was appeared relation between and within groups of patients by used the (ANOVA). Our observations was revealed significance value between total protein and level of thyroxin (T4) and T3 (Triiodothyronine), from another hand , there was high significance value between calcium and thyroxin, also between total protein and thyroxin, but that found significance value between potassium and total protein with thyroid stimulating hormone (TSH) Relationship between hyperthyroidism and total protein, albumin, globulin, liver enzyme and some mineral deficiency. Keywords: Thyroid gland, Histological structure, hyperthyroidism, total protein, albumin, globulin, liver enzymes, mineral deficiency.

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