مريم عصام عبدالله الناصري

Abstract Total sample number 90 were 60 children diagnosed with Acute lymphoblastic leukemia (ALL) collect form Center Tumor cancer in Najaf , Warith international cancer institute in Karbala and select 30 children normal heath ( control) from Amir al-Muminin Hospital and study conduct with molecular lab biology in the Department of Biology / Faculty of Science – University of Kufa, during the period from November 2021 to April 2022, The study demonstrated that there are highly significant differences in the enzyme GSH between those who carry the allele null in patients and control GSTT1, GSTM1and GSTT1&GSTM1 (2.05±1.40 , 2.27±1.73,2.21±1.5) and (3.7±1.9, 3.2±1.8, 3.86±1.7) respectively , the allele present in patients and control GSTT1, GSTM1,and GSTT1&GSTM1 (5.33±0.38 ,4.78±0.68, 5.03±0.7) , (10.64±1.7 , 9.73±2.7 , 9.9±2.5) respectively.

Abstract---Total sample number 90 were 60 children diagnosed with Acute lymphoblastic leukemia (ALL) collect form Center Tumor cancer in Najaf , and select 30 children normal heath ( control) from Amir alMuminin Hospital and study conduct with molecular lab biology in the Department of Biology / Faculty of Science – University of Kufa, during the period from November 2021 to April 2022. The results of This study show GSTM1 and GSTT1 genotypes in 60 children with ALL and 30 healthy controls were compared, Patients and healthy who carried present GSTM1ella allele about ( 26.6% , 40%) respectively , who are of them null GSTM1 (73.3% , 60% ) respectively ,also this study showed the significantly in null GSTT1ella when compared between patients and control (p < 0.00 ). as well as presence the heterozygous ella (GSTT1- GSTM 1- / GSTM1- GSTT1+ & GSTM1+ GSTT1- ) in patient and control about ( 13.3% , 40% , 33.3%) and (6.6% 53,3% ,6,6%) respectively