Malath Hatif Oudah AL-musawi

ABSTRACT The principal objectives of this research were to prepare and evaluate Meloxicam nanoparticles loaded fast dissolving film, and nanoparticles were used to permit for enhancing dissolution of the drug, while the films were used to fasten the onset of action Meloxicam nanoparticles were fabricated by solvent/antisolvent method and then formulated as the oral thin films by casting method. The Meloxicam nanoparticles were prepared at selective polymer: drug ratios of 1:1, 2:1, and 3:1 using various polymers and specific grades of polyvinyl pyrrolidone and hydroxy-propyl methyl cellulose as stabilizers. The effect of polymer, ratio, and stirring rate on the size of the particulate, were studied, and found to have a significant (p ≤ 0.05) effect. The best formula (FMx1) was obtained with a minimum average particle diameter of 59.5 nm and surface area 37.34 m2/g contained 1:1 of HPMCE-50LV: Meloxicam. This formula was freeze-dried and studied for surface morphology by Field Emission Scanning Electron Microscope (FESEM), crystalline state by XRPD, and compatibility by FTIR and DSC. Then Meloxicam nanoparticles were formulated into an oral thin film. The obtained film Meloxicam content of 7.4 ± 0.02 mg per 4 cm2 of film and disintegrated in 29 seconds. The Meloxicam nanoparticles film was illustrated a faster in vitro dissolution rate than the film prepared from pure Meloxicam, and the FESEM images indicated that Meloxicam nanoparticles were greatly distributed into the films. These results indicated that the oral film prepared from Meloxicam nanoparticles could be a favorable system to improve the dissolution and fasten the action. Keywords: Dissolution rate, Meloxicam nanoparticles, Oral thin film, Solvent/antisolvent precipitation. International Journal of Drug Delivery Technology (2021); DOI: 10.25258/ijddt.11.3.5 How to cite this article: Oudah MH, Wais FMH, Al-lam MS. Preparation and Evaluation of Meloxicam Nanoparticles as Oral Thin Film. International Journal of Drug Delivery Technology.

Covid -19 disease in 2020 is considered one of the most dangerous epidemic diseases that afflicted more than a million people in the world, as it quickly turned into delinquent. In this research, we aimed to clarify the clinical relationship of LDH enzyme with this disease. The purpose of this research was that patients who were suffering from a viral infection, lactate dehydrogenase (LDH) were associated with worse results and their condition became very critical, and the relationship between high LDH levels was also examined. Measured at 100 patents in this research, it showed that LDH can be established as a good predictor for early detection of lung infections and serious cases of COVID-19.

Etadolac nanoparticles were prepare by using solvent antisolvent precipitation method,in order to decrease particle size and increase dissolution rate which its rate limiting step in drug bioavailability. Different type of stabilizers used in this study, pvpk30, poloxamer188, HPMCE5, HPMCE15 and HPMCE50. Formulated nanosuspensions were characterize for particle size, poly disperse index(PDI) and specific surface area(SSA). The prepared nanoparticles were characterized by FTIR, SEM, DSC, invitro dissolution rate, and particle size measurement. The results show all particle size within nanosize from from39.5nm to 986nm, with entrapping efficiency range from 90.5% to 98.85%, and dissolution rate at 10min.was 85% for etodolac nanoparticles, and 15.8%, 35% for pure etodolac and physical mixing of drug and polymer, respectively. The results indicate a suitability of precipitation method for preparation of etodolac nanoparticles with enhancement of solubility and dissolution rate.

Preparation and Characterization of DomperidoneNanoparticles for Dissolution Improvement.

Background: Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) having poor water solubility and high permeability. The study aimed to prepare, characterize, and evaluate ibuprofen nanosuspensions to enhance its solubility and dissolution rate. Materials & Methods: This was an experimental and laboratory-based study. Nanosuspensions of ibuprofen were formulated using three different polymers-PVP K30, Poloxamer 188, and HPMC E50-at various drug-to-polymer ratios (1:1, 1:2, 1:3). The study was conducted in a controlled laboratory environment, typically in a pharmaceutical or chemical research laboratory equipped with instruments like particle size analyzers, scanning electron microscopes, and dissolution apparatus. The formulation and characterization experiments were performed in compliance with standard protocols for nanoparticle formulation and pharmaceutical analysis Results: All ibuprofen nanosuspensions were within the nano size range (123-564.5 nm), with the smallest particle size (123 nm) observed for PVP K30 at a 1:1 ratio. The PDI ranged from 0.008 to 0.071, and the specific surface area (SSA) ranged from 18.6 to 3.39 m²/g. Saturated solubility of ibuprofen increased by approximately six-fold compared to the pure drug. Entrapment efficiency ranged from 85% to 97%, while the dissolution rate showed a significant improvement, with 98% of the drug released within 15 minutes, compared to 25% release from pure ibuprofen in the same period. Conclusion: The solvent- Anti-solvent technique is effective for producing ibuprofen Nano-suspensions, significantly enhancing the solubility and dissolution rate of the drug. This formulation approach holds promise for improving the bioavailability of poorly water-soluble drugs like ibuprofen.

Nanoparticle technology is currently widely employed to accelerate drug dissolving and greatly improve bioavailability. Nanoparticles were mixed with hydrogel to create a nanoparticle-hydrogel hybrid system as an alternative to traditional dosage forms. The purpose of this work is to create an effective hydrogel form containing ketoprofen nanoparticles for topical application, ketoprofen a potent non-steroidal anti-inflammatory drug. Eleven nanoparticle formulations of ketoprofen were prepared and characterized for particle size, specific surface area SSA and PDI, by use different polymers (PVP-K15,HPMC-E15 and HPMC-E50) in three different polymer: drug ratio (1:1,2:1 and 3:1).The results indicate increasing in the concentration of PVP K15 generally reduces significantly (p≤0.05) ketoprofen particle size, so select the smallest size formula F3 contain PVP-K15 in ratio polymer :drug (3:1) was 74.9 nm for further characterization which are SEM, X-ray and DSC ,then use this F3 formula to prepare hydrogel and assessment the physical appearance, pH, drug content, spreadability test, viscosity, and in-vitro drug release. The results showed the drug content of ketoprofen nanoparticles F3 in hydrogel was 96.4%, spreadipility was 11.2 gm.cm2/sec, hydrogel viscosity was (6500cps to 75400cps), and drug release from F3 hydrogel was 96.13% at 10hr. there was a significant enhancement in drug release from this nanoparticle hydrogel than plain ketoprofen hydrogel.

drug safety in pregnancy held in period from 2-6\3\2025 targeting researcher and graduate student , to learning drug safety during pregnancy and disease during this period

this course held at 24-3-2024 for five days targeting the post graduate student an d researcher

application of nanoparticles in novel cosmetic preparation held at 21-4-2024 in faculty of pharmacy university of kufa targeting researcher and post graduate student

community study

the course was held at the faculty of pharmacy university of kufa at 22-26/9/2024

smart drug delivery held for period from 9-14/4/2021 targeting researcher and graduate student, during which we explained modern methods of manufacturing medicines in smart and more effective methods.