Histological evaluation of local application of cress seeds oil on wound healing in facial skin rat
Background: The process of skin healing necessitates the restoration of the body's structural integrity. This physiological process includes the extracellular matrix, blood cells, cytokines, and growth factors. Cress seed oil is a widely utilized herbal remedy that is believed to have medicinal activities as an antioxidant, antimicrobial, and anti-inflammatory. Objective: Assess the influence of applying cress seeds oil directly to facial cutaneous wounds in rats to determine its effect on healing. Materials and Methods: Sixty male Albino rats, with an average weight 200 -300 g were studied. Full thickness surgical incisional wounds were made in the cutaneous surface of each rat's cheek. The rats have been divided into the subsequent groups using random assignment: Control group: (n=30), where wounds were allowed to heal without any intervention. Experimental group: (n=30), wounds were treated daily with topical application of cress seed oil. Assessment of wound contraction, epithelial thickness, inflammatory cells and blood vessels quantification. The animals had scarification at the healing periods (days three & seven). Results: There is a noticeable rise in wound contraction and epithelial thickness over time with a significant difference observed in the experimental group at day 7. The number of inflammatory cells reduced over time. The experimental group exhibited the highest mean values for blood vessel count on day 7. Keywords: Cress seeds oil, Skin Wound Healing, Angiogenesis, Albino rats, Anti-inflammatory. Introduction Conclusion: The findings of current study indicate that the topical application of cress seeds oil improves the healing process in skin wounds of rats.