جنان مهدي غني خليفة

Treating herbl medicines, based on their long-term widespread use as anti-fertility agents, conversely it`s possible to have herbs that are effective for improving fertility. Endometrium of the uterus undergoes enormous renovation in response to systemic changes in reproductive hormones (progesterone and estradiol) during each reproductive cycle).Twenty five health mature female mice (aged 8 weeks) divided into five groups (5/each) were participants in the current to investigate the fertility effects of Origanum vulgare against the reproductive toxicity induced by Fenugreek. These effects examine by measuring the number of ovarian follicles, thickness of the uterus and steroid hormone levels (estrogen & progesterone) in serum. The results showed no significant differences (p>0.05) in number of ovarian follicales, steroid hormones level, and lower in thikness layers of uterus tissus the experimental treated groups with Fenugreek (250 mg/kg and O.vulgare (90,180,270) mg/kg respectively. Depending on these outcomes, the hot aqueous of O. vulgare has enhancement reproductive system in female albino mice, and these results give additional scientific support to maybe use O. vulgare as an alternative for problems of fertility

Gabapentin (GPN) is an anti-seizure drug that has also been prescribed for managing nerve pain and other ailments. However, its abuse has become an increasing concern, as it might lead to a serious health hazard. This study was therefore conducted to investigate the effects of oral administration of GPN drug on hematological blood parameters, as well as examine histological changes in vital organs of laboratory mice. Twenty female mice were obtained for the study and divided into four groups (5 mice each). The control group (G1) was maintained on a standard ration and treated orally with 1 ml of distilled water. Treatment groups; G2, G3, and G4 were administered with GPN (1, 0.5, and 0.25 mg/kg body weight, respectively) for 8 weeks. At the end of the experiment, the animals were sacrificed and the blood was collected for hematological analysis and histological examination on the liver and kidney. The results revealed that in the GPN-treated G2 (1 mg/kg body weight), a significant (p<0.05) decrease in WBC count was observed compared with the control group (G1), but the differences among the other groups were not significant. There was a significant decrease in the RBC, MCV, and MCH values, compared to the G1. Conversely, RDW, PLT, liver enzyme function and kidney parameters in all the GPN-treated groups (G2, G3, and G4) increased significantly in relation to the G1. Furthermore, the pathohistological study revealed extensive damage to the liver tissues and hepatocyte cord in the G2; moderate damage in the G3; while no obvious change was observed in the G4. Our findings indicated that the use of GPN as an anti-arthritis drug at high doses is associated with a long-term wide range of side effects in the body, and its use is therefore recommended at lower doses.

The present study on the Albino female rats show the effects on blood parameters induced by repeated administration of three doses of androgenic anabolic steroid (dianabol). The animals were divided in to four groups (6 animals for each group). The first group is considered as a negative control treated with diet and water only. Second, third and fourth treatment groups gives orally pendent dianabol (10, 30 and 50) mg/kg/day respectively, and all groups quaff for 6 weeks.The result showed that significant increase`(P<0.05) in RBC, WBC count, HB, HG, PCV, lymphocyte, platelet count, and percentage of lymphocyte in treatment groups compared with control. The results refer that significant decrease`(P<0.05) in mean corposclar Hemoglobin and concentration (MCHC), while the mean of corpuscular hemoglobin(MCH) and corpuscular volume (MCV) show significant increase `(P<0.05) compared with control group

The effect of orally feeding of hot liquid extract of (Matricaria chamomilla flowers) on hepatotoxicity induced to male mice by methomyl ,S-methyl-1-N- [(methylcarbamoyl)oxy]thioacetimidate (IUPAC) was investigated for( 30 days). These effects could be explored by measuring any changings in the weight of both body and liver.Histopathological examination of liver has been performed also along with aspartate aminotransferase(ALAT) and alanine aminotransferase (ASAT) levels in serum. The results showed that the poisoned group treated with pesticide by using two doses of hot aqueous extract of chamomile (5 and 7) mg / kg of body weight have shown a marked improvement of the symptoms of pesticide poisoning, compared with the positive control group of the pesticide and that the dose of the methomyl 90% led to the toxic effects appeared by decreasing in body weights in mice and noticeable changes in liver tissue accompanied by increasing in its weight.There was significant increasing in the level of liver enzymes (ASAT, ALAT), Histopathological examination of liver sections of mice administered Matricaria chamomilla hot aqueous extract demonstrated reduction of damaged liver tissue induced by methomyl 90%.Current study reveals that hot aqueous extract of Matricaria chamomilla promises protection for hepatocytes against methomyl 90%- hepatotoxic mice induction. Finally,this study recommends that intake of hot aqueous extract of Matricaria chamomilla could be useful for liver disorders.

Methomyl is labeled as a carbamate insecticide. The existent study was projected to research the effect of oral administration of the hot aqueous extract of (UMatricariaU Uchamomilla Uflowers) to (4weeks)on the histopathological alterations of methomex_induced kidney harm in male mice. Methomyl administration caused increment the in grades of creatinine and urea of serum. The histopathological study to kidney appeared the devastation of the normal modality of the renal tissue and significantly existence of several glomeruli showed atrophy with tumescence of bowman's space ,strong stretching of the tissue of cortex tissue and degradation of the epithelium cells which lining the tubules. Pre-administration with UMatricariaU UchamomillaU extract as a herbal tea perhaps has preventative influence against methomyl toxic impacts of the kidney.

This study is designed to investigate the role of cholesterol, high density lipoprotein HDL, low density lipoprotein LDL and triglycerides TG in the increased incidence of benign breast tumors among women. This study involved 80 women divided into two groups: control group which including 40 healthy women and benign group which containing 40 women with benign breast tumors diagnosed by the means of fine needle aspiration and ultrasound. The age of women in benign group ranging from under 20- 60 years, blood sample was collected from each women for measuring lipid profile (cholesterol, high density lipoprotein HDL, low density lipoprotein LDL and triglycerides TG). The results explained that benign breast tumors was more common in women with interval age 20-30 years. The results also revealed that the age at menarche and abortion were significantly P≤ 0.05 associated with increased risk of benign breast tumors . The results clarify a significant P≤ 0.05 increasing in the levels of cholesterol, high density lipoprotein HDL and triglycerides TG) in women in benign group in compared with healthy women, reflecting that increased lipid profile may contribute in increasing risk of benign breast tumors. Finally the statistical analysis of this study was showed that obesity reflecting by measuring body mass index BMI significantly decreased in women with benign breast tumors in comparison with control group, the matter that explain benign breast tumors less incidence in obsess women.