حذام محمود يوسف اللبان

ABSTRACT: Preparation of Schiff bases compounds (A, B, and C) in absolute ethanol using concentrated phenyl hydrazine and various aromatic aldehydes such as (4-chlrobenzaldehyde aldehyde, 4-bromobenzaldehyde, N, N-dimethyl amino benzaldehyde). Melting point, FT, has been used to classify these compounds (A, B, and C). The reactions phases and series were studied using IR spectroscopy and thin layer chromatography (TLC) (ethyl acetate: toluene, 1:4). Three derivate compounds were used as antibacterial activity in this study. The results proved that all derivative compounds provided good inhibition zone against Staphylococcus aureus and pseudomonas aeruginosa especially in concentration 300mg/ml of derivative compound C with diameter inhibition zone 21.433±0.676 and 625.33±0.796 respectively.

Abstract: Sensitive and simple kinetic approaches are explained for the chloramphenicol assessment in pure form as well as Pharmaceuticals. The approach are depended on Reduction as well as spectrophotometric assessment of chloramphenicol Antibiotic (by zinc powder and concentrated hydrochloric acid) and followed the reaction with Trifluoperazine in the existence of sodium per iodate that producing a strongly colored result at the temperature of room, the color product from this reaction measured spectrophotometrically at λmax= 503 nm. On constant time (at 2 minutes) approach are exercised for the assessment of concentration. The linear calibration curve were happened in the concentrations extent (0.5-22 ppm) sequenceally .The outcomes were confirmed statistically additionally restricted during the of studies recovery, as well as make been exercised with success for the assessment of chloramphenicol in official dose forms.

Summary This study aimed to synthesis of some new 1,2,3,4-Tetrazole derivatives from o-tolidine as a starting materials and measurement of antibacterial activity against two type of pathogenic bacteria (Staphylococcus aureus and Klebsiella pneumoniae) isolated from patients infected with burns infections: The first step includes formation new Schiff bases derivatives from o-tolidine [A] was concentrated with many aromatic aldehydes [4-chlrobenzaldehyde, 4-bromobenzaldehyde, p-dimethyle amino benzaldehyde] in absolute ethanol to give [A1-A3]. The second step includes synthesis [B1-B3] by diazotation of [1-(4-aminophenyl) ethanone, 4-amino-N-(2H-imidazol-2-yl) benzenesulfon amide, 4-nitroaniline], respectively. The formed salt was treated with sodium azide, ethyl acetoacetate and acetylacetone, respectively. [B1-B3] Compounds were entered in 1, 3- dipolar cycloaddition reactions with [A1-A3] in dimethylformamide to give 1, 2, 3, 4-Tetrazole derivatives [AB1-AB3]. Antibacterial activity of nine derivative compounds were done against two types of pathogenic bacteria (p. aeruginosa and S. aureus) the results of this study proved that there were significant bacterial inhibition against p. aeruginosa and S.aureus with inhibition zone 20 mm and 15 mm, respectively.

Abstract: new 1,3-oxazepine derivatives containing azo group have been prepared. The first step, ( benzidine) was converted to 4,4'- bis(3-amino phenol)Azo benzidine [A]. by coupling reaction with 3-amino phenol, Then amine group of the azo derivative [A] was condensed with different aromatic aldehydes [4-chlrobenzaldehyde,3-hydroxybenzaldehyde,p-dimethyleamin -obenzaldehyde,4-bromobenzaldehyde,4-hydroxy-3-methoxybenzaldehyde,4-chloro-3-hydroxy- benzaldehyde, 3,4-dimethylbenzaldehyde, 4-hydroxybenzaldehyde ] in absolute ethanol to give new azo Schiff bases derivatives [B1-B8] respectively. resulting imines derivatives [B1-B8] were reacted with maleic anhydride and phathalic anhydride in dry benzene to give new 1,3-oxazepine-4,7-dione ring derivatives[C1a-C8a]and[C1b-C8b] respectively. For the last derivatives thermal properties were determind by using Thermo gravimetric analysis (TGA),All these compounds were characterized by melting points and FT.IR spectroscopy, some of them were characterized by1H-NMR spectroscopy ,C.H.N analysis and TGA analysis.

Abstract The present study aimed to compare some microbial and Physiochemical parameters of Al-Kufa and AlManathera water before treatment (river water) and after treatment , the results revealed that there was significant increase (p=0800.0) in total available count (TVC) of Al-Kufa water before and after treatment since it was ( 068222 cfu/ml and 0 cfu/ml) respectively . Moreover there was significant increase (p=080000) in total available count of Al-Manathera water before and after treatment since it was ( 608222 cfu/ml and 0 cfu/ml ) respectively . The results of present study indicated that there was significant increase( p=08000. ) in total coliform count (TCC) in Al-Kufa water before and after treatment since it was ( 628222 cfu/ml and 0 cfu/ml ) respectively and there was significant increase ( p=0800.6 ) in total coliform count in Al-Manathera water before and after treatment since it was ( 06866 cfu/ml and 0 cfu/ml) respectively , and the results of this study improved that there was no growth for Salmonella.spp and V.cholera in Al-Kufa and Al-Manathera water after treatment. Also the present results indicate that there was significant increase( p= <0.0001 ) in total dissolved solids (TDS) in Al-Kufa water before and after treatment when it was ( 1188.3 ml/l and 854.67 ml/l) respectively , and there was significant increase ( p=<0.0001 ) to total dissolved solids in Al-Manathera water before and after treatment when it was ( 854.67 ml/l and 869.00 ml/l ) respectively , also the study improved that there was significant increase( p=<0.0001) in turbidity in Al-Kufa water before and after treatment when it was ( 34.667 ftu and 3.3133 ftu) respectively , and there was significant increase ( p=<0.0001 ) in turbidity in Al-Manathera water before and after treatment since it was ( 38.000 ftu and 3.2567 ftu ) respectively , and there was no significant increase between Al-Kufa and Al-Manathera water in turbidity after treatment , also the results demonstrated that was no significant increase between Al-Kufa and Al-Manathera water in acidity (PH) levels before and after treatment.

Heterocyclic compounds contain five-six-and seven-membered rings and have heteroatoms of oxygen (O), nitrogen (N) or sulfur (S). According to the previous, synthesized of new organic compound such as tetrazoles, Pyrimidines and Oxazepine. The results proved that tetrazoles and Pyrimidines have good antibacterial activity while thermo properties for Oxazepine compounds are results indicated that stability to it. Electron removal decreases reaction rate and increases time, while electron reaction donation increases reaction rate and decreases reaction time.