فلاح عبد الحسن دلي الزرفي

Background:SARS COV 2 (COVID 19) is continuing to be a big global challenge and a great impact of this disease is laid on the health care workers, we aim in this study to evaluate the observed high mortality among Iraqi doctors.Patients and methods:This is an observational and cross-sectional study on Iraqi doctors documented to die due to infection with COVID 19 and the analyzed according to the age, gender, specialty and subspecialty if present and whether retired or still employed the results were compared with the most acceptable results of the worldResults: 77 Iraqi doctors had died because of COVID 19, 73 (95%) males and four females (5%), 23 doctors were retired (29.9) .The ages ranged between 30-83 years with a mean of 57.9±10.8 .The proportion of doctors death per 10000 clinical cases was 2.6 versus 1.9 globally (non-significant difference) while the proportion of doctors death per 10000 deaths of the society was 98.5/10000 versus 30.2/10000 globally and the different was markedly significant Conclusions and recommendations:Iraqi doctors have a relatively high mortality rate due to COVID 19 and all specialties were involved urging consideration of better actions by medical administrative authorities.Keywords:COVID 19; Iraqi doctors; Mortality

Infection is presumed to have a rule in the promotion of asthma exacerbations, and in deterioration of the course of the disease, Chlamydia pneumoniae (C. pneumoniae) is claimed to be a possible cause for these two issues. To assess the positivity and the titer of C. pneumoniae IgG antibodies in relation to the state of asthma and its severity. 61 asthmatic patients aged 15-85 years (mean of 47.10±14.887), and 29 apparently healthy, nonasthmatic age and gender-matched volunteers (control group) were assessed as at Asthma and Allergy Clinic in Al-Sader Medical City in AL-Najaf province, Chlamydia Pneumoniae IgG ELISA Kit was used for the detection of IgG antibody to C. Pneumoniae in human serum to detect chronic infection, and Spirometric test was done, and the best results for FEV1 and peak expiratory flow rate (PEFR) were taken. IgG antichlamydial antibodies were positive in 21 (34.4%) of patients compared to 4 (13.8%) of controls, and the difference was significant with OR=3.281, the seropositivity in acute exacerbation was more than in stable asthmatic, 43.8% vs. 24.1% (P=0.029), seropositivity was nonsignificantly more in moderate and severe asthma as compared with mild asthma, a significant inverse correlation between IgG titer and pulmonary function test parameters (FEV1, PEFR) was observed as the FEV1 & PEFR values decrease with increase IgG titer. Chronic C. pneumoniae infection is common in adult asthmatics and correlated with exacerbations & increased severity and disturbed lung function.

Asthma is an important community problem that increased in incidence worldwide, with a considerable acute and chronic sequale and being an inflammatory process, following and interrupting this process is extremely important. High‑sensitivity C‑reactive protein (hs‑CRP) is proposed to be a good indicator for the degree of inflammation; we aimed to utilize hs‑CRP as an inflammatory biomarker to assess the severity and stability of asthma. Patients and Methods: Forty‑one asthmatics (19 males and 24 females) with a mean age of 41 ± 14 and 22 years and gender‑ and body mass index‑matched controls were assessed by questionnaire, spirometry, and level of hs‑CRP in Al‑Sader Teaching Hospital in Al‑Najaf at 2018. Results: The mean values of hs‑CRP were significantly higher in asthma than the control group, and this was marked in asthmatics during acute exacerbation than those with stable clinical status, hs‑CRP was recorded significantly higher in adult asthmatic patients as compared to adolescents and middle aged, smoking history and allergic history did not show any significant difference, and the elevation of hs‑CRP was markedly more in acute exacerbation as compared to stable state; on the other hand, the level of hs‑CRP was correlated significantly more with the drop in forced expiratory volume1 and peak expiratory flow rate, indicating the relation with the severity of the illness. Conclusions: Hs‑CRP can be considered as a good biomarker for assessing the severity and stability of asthma. Keywords: Asthma, forced expiratory volume1, high‑sensitivity C‑reactive protein, peak expiratory flow rate, spirometry

The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide. Many studies carriedout in several populations exhibited an association of adiponectin receptor 1 gene ( AdipoR1 )polymorphisms with type 2 diabetes mellitus. Methods A case-control study was conducted to verify the association of AdipoR1 polymorphisms(rs1342387 G>A and rs12733285C>T) with T2DM in Iraqi population. The study included 400T2DM patients as well as 400 healthy control individuals. DNA was extracted from whole bloodand genotyped for the analyzed genes by PCR-RFLP. The odds ratio for the risk of developingT2DM was calculated after adjustment for age, sex, and BMI. Multinomial logistic regressionanalysis was applied to compare the results. Results The genotyping of rs1342387 G>A SNP in AdipoR1 highlighted an insignificant (OR = 1.53, CI95% = 0.88–6.32 & P = 0.08) difference of the AA genotype in T2DM patients when compared withthe control group. Similarly, the AG genotype was insignificantly (OR = 1.27, CI 95% = 0.93–1.74 &P = 0.14) changed among the two groups after sex and age adjustment. The minor allele frequency A was insignificantly (P = 0.13) differed in T2DM patients (29.88%) with respect to the controlgroup (26.25%). The assessment of characteristics-genotype distribution relationship in T2DMpatient group revealed significant elevations of BMI (P = 0.03) and HOMA-IR (P = 0.02) values insubgroups carried the A allele when compared with those of the reference alleles. The evaluationof the results of the genotype distribution, minor allele frequency and characteristics-genotypedistribution relationship for the rs12733285C>T SNP failed to point out significant alteration. Conclusion AdipoR1 polymorphisms (rs1342387 G>A & rs12733285C>T) do not associate directly with T2DMin Iraqi population. However, there may be an indirect impact via the directing of insulinresistance and BMI.

Background Type 2 diabetes mellitus (T2DM) incidence is increasing globally and nationally. The etiology of the disease includes environmental and genetic factors. Polymorphism of adiponectin gene was found to be implicated in the pathogenesis of T2DM in numerous populations. Methods A case-control study was conducted to assess the association of rs2241766 and rs822395 SNPs of adiponectin gene (ADIPOQ) with T2DM in Iraqi population. The study included 400 patients with T2DM and 400 healthy individuals served as a control group. Serum lipid concentrations, insulin level and the index of insulin resistance (HOMA) were measured. The genotyping of ADIPOQ for rs2241766 and rs822395 SNPs was performed by PCR-RFLP. Results The genotype distribution of rs2241766 SNP indicated a significant increase of carriers of the homozygous GG (OR: 5.04, CI95%: 2.27–11.19, P: 0.0001) and heterozygous TG (OR: 1.7, CI95%: 1.22–2.39, P: 0.002) variants when compared with those of the wild type, suggesting a risk factor of 2 and 5 to develop the disease. The minor allele frequency (MAF) G was observed to be significantly (P: 0.0001) higher in patients (22%) when compared with the control group (11.74%). Results of rs822395 SNP failed to exhibit a significant difference. Changes of BMI, cholesterol, triglycerides, insulin and insulin resistance index values in the diabetic patients seemed to be parallel with the presence of MAF of rs2241766 SNP. Conclusion The rs2241766T>G SNP of adiponectin gene is a risk factor for the development of T2DM in Iraqi population and directs the changes of serum lipid concentrations as well as insulin resistance.

Enterobiasis is the commonest intestinal helminthic disease and is long believed to be a simple illness with no important local or systemic invasive complications. A cross-sectional analytic study of 175 patients attending the surgical clinics with complaints of perianal lesions like perianal fissure, perianal fistula, perianal abscess and perianal pruritus and excoriation. Forty two (93%) of the patients in the first group had a low serum zinc (mean 7.27umol/l), this was significantly lower than the second group and the two control groups (patients with uncomplicated Enterobiasis and a normal control group), however, the mean serum level was lower than normal in these groups. After treatment of the first group with two doses of Mebendazole (100mg) at two weeks interval, 8 patients (18%) had complete cure of their perianal pathology (two anterior perianal fissure and eight pruritus and Article Info excoriation), 10 patients (22%) had a moderate response and 13 patients (29%) had a mild response. Out of 175 patients, 45 patients had enterobiasis on twice scotch tape tests. There were 34 (76%) males and 11(24%) female positive cases of enterobiasis. Perianal fissure was the most common lesion in both groups: 30 (67%) in the first group versus 96 (75%) in the second group. Perianal pruritus with excoriation occurred in 14 cases (31%) in the first group and 16(12%) in the second. Perianal fistula and perianal abscess occurred in 5(11%) and 3(6%) in the first group and in 26(20%) and 24(18%) in the second group respectively.

تم قبول بحث في مجلة عالمية ضمن مستوعبات سكوباس كباحث ثاني يتناول تاثير السمنة على وظائف القلب

تم قبول بحث في مجلة عالمية ضمن مستوعبات سكوباس كباحث ثاني يتناول تاثير السمنة على وظائف القلب

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