فهد نجد عبيد المالكي

Abstract Background: Thyroid gland is an essential endocrine gland that secretes hormones that control growth, development, and metabolic activities. The need for better detection techniques is highlighted by the rise in thyroid cancer incidence in recent years. Current techniques, such as imaging and hormonal evaluations, are useful, but they frequently don't have enough sensitivity for early identification. Advanced blood biomarkers like CK-19 and Gal-3, as well as hormonal thyroid function tests like T3, T4, and TSH, may improve diagnosis accuracy and offer chances for early management. Material and Method: A total of 60 blood samples of patients of women with papillary thyroid cancer (PTC) between ages 20 and 50 years were collected from patients, which were divided into 40 women who were given treatment and 20 women who did not take any treatment; they were all collected from the laboratory of the National Hospital for Oncology and Blood Diseases in Najaf Governorate. Also, thirty samples were collected from healthy women between ages 20 and 48 years from students of the University of Altoosi/Department of Medical Laboratory Techniques in Najaf Governorate. serum was used for estimation immunological biomarkers, such as Gal-3and CK-19 by enzyme-linked immunosorbent assay (ELISA) and estimation T3, T4 and TSH by Mini VIDAS analyzer. Results: Results was showed PTC patients under treatment showed elevated thyroid stimulating hormone (TSH) and thyroxin (T4) levels but, lower triiodothyronine (T3) significantly at p-values ≤ 0.05 when compared to untreated patients and healthy women. Resulted also was showed the untreated patients' group had significantly higher levels of in cytokeratin-19 (CK-19), and galectin-3 (Gal-3) at p-values ≤ 0.05 when compared to the control group (healthy women) and the treated patients' group with papillary thyroid cancer. Conclusions: TSH, T4, and T3 are ineffective as standalone diagnostic markers for PTC, therefore depending on just these hormonal biomarkers is insufficient for accurate diagnosis, and additional biomarkers such as CK-19 and Gal-3 are necessary for effective screening and diagnosis of papillary thyroid cancer in women.

Abstract Background: One important endocrine organ that generates the hormones that control growth, development, and metabolism is the thyroid gland. Thyroid cancer is becoming more common, which highlights the need for better screening techniques. Current methods, such hormonal assessments and imaging, are helpful, but they frequently lack the sensitivity needed for early identification. More sophisticated blood tests, such as IL-8 and TG, as well as hormonal thyroid function tests, such as T3, T4, and TSH, may help physicians make more precise diagnoses and start therapy earlier. Material and Method: A total of 60 blood samples of patients of women with papillary thyroid cancer (PTC) between ages 20 and 50 years were collected from patients, which were divided into 40 women who were given treatment and 20 women who did not take any treatment; they were all collected from the laboratory of the National Hospital for Oncology and Blood Diseases in Najaf Governorate. Also, thirty samples were collected from healthy women between ages 20 and 48 years from students of the University of Altoosi/Department of Medical Laboratory Techniques in Najaf Governorate. serum was used for estimation immunological biomarkers, such as IL-8 and TG by enzyme-linked immunosorbent assay (ELISA) and estimation T3, T4 and TSH by Mini VIDAS analyzer. Results: Results was showed PTC patients under treatment showed elevated thyroid stimulating hormone (TSH) and thyroxin (T4) levels but, lower triiodothyronine (T3) significantly at p-values ≤ 0.05 when compared to untreated patients and healthy women. Resulted also was showed Interleukin-8 (IL-8) levels in this study were significantly increased at p-values ≤ 0.05 in untreated patients than in controls and treated patients, but no significant difference at p-values ≤ 0.05 in TG levels among the groups for distinguishing between treated and untreated PTC patients or between PTC women patients and healthy women (control). Conclusions: IL-8 is an immunological biomarker with excellent diagnostic potential; IL-8 has the best sensitivity and specificity; also, TSH, T4, and T3 are ineffective as standalone diagnostic markers for PTC.

Filgrastim is an anticancer drug used for the treatment of cancer patients that suffering neutropenia, on the last years found filgrastim has an adverse effect and wreak lesion on different organs as testis that attributed to formation reactive oxygen species. In general, the last studies suggested to used natural substance beside the anticancer drug for decreased the reactive oxygen species as well as curcumins and lycopene. The Ocimum tenuiflorum generally used as antiinflammation and antioxidant, thus our study aimed for evolution the productive effect of Ocimum tenuiflorum against filgrastim. In the study 40 male rats was used and divided in 4 equal groups which the 1st group was intraperitoneal injected of 30.83 mcg/kg/day of Filgrastim for one week, the 2nd group that treated with of Ocimum basilicum suspended in corn oil and administered by gavage at 20 mg/kg for 2 week, while the 3rd group that rats was intraperitoneal injected of 30.83 mcg/kg/day of Filgrastim for one week beside that treated with Ocimum tenuiflorum group and finally the 4th group treated with placebo, than, after 40 days of experiment, evaluation of sperm parameters. In conclusion our result proved that Ocimum tenuiflorum has productive effect against adverse of filgrastim.

The study was shown by the research laboratories of the Department of Biology / Faculty of Science/ University of Kufa for a period for six months, 40 male rats were used and were divided into three groups; Group A: male rats administered with drinking water as negative control (N. C.) Group B: male rats undergo Bile duct ligation for one week, At the end of the treatment period, male rats were sacrificed and blood samples were obtained for assessment of (CDT levels and levels of T.C, T.G., LDL and VLDL) . The result has no significant change (p > 0.05) in the level of CDT, and then lipid profile levels show a significant elevate in cholesterol, TG, VLDL, and LDL in rats undergoing BDL compare to control groups.

The impact of COVID-19 on the general and psychological health and educational status was scored according to previous studies which found left a big negative impact on education. moreover, covid-19 is the greatest challenge that these expanded national education systems have ever faced. many governments have ordered institutions to cease face-to-face instruction for most of their students, requiring them to switch, almost overnight, to online teaching and virtual education. Thus, study aimed to evaluate the effect of COVID-19 pandemic on the different undergraduate students during 2020-2021 across the questionnaire format through the view of the student

Their study was led to explore the impact of finasteride (Prostacare) on testicular capacity in Rattus Norvegicus. Forty five matured male rats with body weight of (200-300g) and (8) to (10) weeks of age were divided into (3) groups (15 rats/group). The first group was given orally with distilled water as acontrol and the others (second and third) were given orallywith two concentrations of finasteride (5mg/kg.b.w and 10mg/kg.b.w) daily for a period of (eight weeks). After the finish of the experiment, rats was scarifiedfor the purpose of histological study and measurement of organs weights in the laboratory. The results showed a significant (p<0.05) decrease in the body, testis, epididymis and prostate gland weightsin compared with the control. Also the results of histological examination of testis and epididymis showed a significant (p<0.05) reduce in the seminiferous tubules diameters and reduction in number of the leydig's cells, while there was a significant (p<0.05) rise in the interstitial spacebetween tubules compared to the control group. The results was showed necrosisin the seminiferous tubules of the testis.

ناقش التدريسي (الدكتور فهد نجد عبيد المالكي) اهم واحدث الطرق لتشخيص والتنبأ بسرطان الغدة الدرقية و خصوصا في النساء وضرورة متابعة حالة المرضى المصابين بقياس بعض الاختبارات المناعية مثل (Ck-19 ,Gal-3 ,IL-8)وعدم الاكتفاء بقياس فقط Tg وهرومانات الغدة الدرقية (T3,T4,TSH) كون وحدها ليست كافية ودعمها بالمؤشرات المناعية حيث تعتبر اكثر حساسية وخصوصية في دم المصابين وكذلك في الخزعة النسيجية للخلايا وبالتالي توفر متابعة ومراقبة أثناء فترة العلاج لعدم تطور المرض والسيطرة عليه