EFFECT OF ALCOHOLIC EXTRACT OF Brassica oleracea L. VAR. CAPITATA
PLANT LEAVES ON GLUCOSE LEVEL AND ANTIOXIDANT ACTIVITY IN ALLOXANINDUCED
DIABETIC RATS
الباحث الأول:
مهدي حمزة خشان
الباحثين الآخرين:
د.زينب شنيور الطرفي
المجلة:
تايلندا
تاريخ النشر:
None
مختصر البحث:
Objective: The aim of this study was to investigate the effect of ethanolic extract of Brassica
oleracea var. Capitata (Cabbage) Plant Leaves of Glucose Level and Antioxidant Activity in
Alloxan-Induced Diabetic Rats.
Methods: Thirty mature male …
Objective: The aim of this study was to investigate the effect of ethanolic extract of Brassica
oleracea var. Capitata (Cabbage) Plant Leaves of Glucose Level and Antioxidant Activity in
Alloxan-Induced Diabetic Rats.
Methods: Thirty mature male rats were used in five groups, the first group kept as a normal
group. The second group (Diabetic group) received a single dose of alloxan (150 mg/kg BW
i.p.) to induction of Diabetes mellitus type 2 (T2DM) while the third, fourth, and fifth groups
were diabetic rats received 150, 300, 600 mg/kg, respectively, of Brassica oleracea var.
capitata ethanolic extracts orally for 60 days after induction of T2DM. Body weights were
recorded after and before treatment. Animals were sacrified after 24 h of the last dose and
heart blood samples were collected for biochemical study.
Results: The presence of a significant decrease (P < 0.05) in the body weights and reduced
Glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase1 (GPX1) levels
and significant increase (P < 0.05) in the Fasting plasma Glucose (FPG) and malondialdehyde
(MDA) levels in the diabetic group compared with normal group. In contrast, it was noted the
presence of significant increase (P < 0.05) in the body weights and GSH, SOD and GPX1 levels
and significant decrease (P < 0.05) in the FPG and MDA levels in diabetic rats that treated with
300, 600 mg/kg BW of extract as compared with diabetic group rats.
Conclusion: The present study ascertains that the Ethanolic extracts of Brassica oleracea var.
Capitata Plant Leaves possesses antihyperglycemic and antioxidant properties.
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