ASSOCIATION OF LOW DENSITY LIPOPROTEIN RECEPTOR GENEPOLYMORPHISM (rs6511720 AND rs11669576) WITH CORONARY ARTERYDISEASE IN IRAQI POPULATION
الباحث الأول:
Majid Kadhum Hussain1
الباحثين الآخرين:
Abdul Hussein A. Algenabia2, Zainb M.J. Alkhateeb3 and Ahmed Rgeeb41,
المجلة:
Biochem. Cell. Arch.
تاريخ النشر:
None
مختصر البحث:
ABSTRACT : Coronary artery disease is a serious health problem in the world as well as in Iraq. The genetic background ofthe disease is still unclear in particular, the involvement of low density lipoprotein receptor gene polymorphisms. Aim: Toasses…
ABSTRACT : Coronary artery disease is a serious health problem in the world as well as in Iraq. The genetic background ofthe disease is still unclear in particular, the involvement of low density lipoprotein receptor gene polymorphisms. Aim: Toassess the influence of 2 SNPs (rs6511720 and rs11669576) of low density lipoprotein receptor gene on the development ofcoronary artery disease and serum lipid concentrations in Iraqi population. Five hundreds individuals were recruited in a casecontrol study, 250 patients with coronary artery disease and 250 healthy persons. Serum lipid concentrations were determinedby standards methods. Genotyping of low density lipoprotein receptor gene polymorphisms (rs6511720 and rs11669576) wasachieved by restriction fragment length polymorphism-polymerase chain reaction. Patients carried the genotype TT+GT of thers6511720G>T SNP were found to be significantly (P: 0.025) increased in comparison to those in the healthy group when theanalysis was achieved under the additive model. The minor allele frequency was evident to be significantly (OR: 1.39; 95%CI:1.00–1.93; P: 0.046) elevated in the patients relative to the control individuals. Data of the rs11669576G>A SNP explored asignificant elevation of patients carried the genotypes GA+AA relative to the control persons under the dominant model (P:0.039) and the additive model (P: 0.0001). The minor allele frequency showed a significant (OR: 1.31; %95CI: 1.01–1.69; P:0.034) increment in the group of patients when compared with the control group. HDL-c concentration was found to besignificantly (P: 0.022 for the T allele of rs6511720G>T SNP and P: 0.011 for the A allele of rs11669576G>A) elevated in thepatients group relative to the control group when the assessment was achieved under the codominant model. The 2 investigatedSNPs were associated with CAD in Iraqi population, but not with LDL-c concentration. However, such association was evidentwith HDL-c concentration.Key words : rs6511720, rs11669576, LDLR, CAD, Iraqi society.How to cite : Majid Kadhum Hussain, Abdul Hussein A. Algenabia, Zainb M.J. Alkhateeb and Ahmed Rgeeb (2021)Association of low density lipoprotein receptor gene polymorphism (rs6511720 and rs11669576) with coronary arterydisease in Iraqi population.
