High mobility group box protien- in
gallstones patient1(HMGBP1) level
الباحث الأول:
سهى حسين محمد
الباحثين الآخرين:
ارشد نوري الدجيلي
وسيم احمد الكاتب
المجلة:
AIP Conference proceeding
تاريخ النشر:
None
مختصر البحث:
tructure of gallstone depand on basically and can be classified into three forms mixed stone, pigment stones and cholesterol stones and pigment also different from brown or black in addition to many constitutes such bilirubin, calcium phosphate, ca…
tructure of gallstone depand on basically and can be classified into three forms mixed stone, pigment stones and cholesterol stones and pigment also different from brown or black in addition to many constitutes such bilirubin, calcium phosphate, calcium carbonate in addition to calcium palmitafe. Many between brown and black pigments mainly the calcium bilirubinate is a main substance of brown pigments while bilirubin and calcium are the major component of brown pigment. One of the major protein that belong to anon histone protein called High mobility group box-1 (HMGb1) and damage by stress in one of major response to release HMGB1. The study was applied on 120 people aged 30-69 year: 60 patient group with gallstone and 50 healthy group as a control group. The group of patients was divided into subgroups based on gender, age, BMI, type of stones, diameter of stones and before and after operation. The complete blood count was examined for all the patients group and healthy group. HMGB-1 serum level was highly elevated (p<0.05) in gallstone patients than control. Before operation show significant increase (p<0.05) in HMGB-1 serum compare with after operation. In female the level of HMGB-1 non a significantly difference (p<0.05) and indicated significantly difference (p<0.05) in HMGB-1 between different ages, different type of body mass index (normal weight, over weight and obese weight) and different type of gallstones (mixed, pigment stones and cholesterol stones) of gall stones patients group respectively. The results of correlation and linear regression indicated significant positive (p<0.05) correlation between HMGB-1 and liver enzymes (ALT, AST and ALP), lipase, bilirubin and leukocytes respectively. Current study was aimed to determine HMGB-1 which can be used for diagnosis and prognosis of gallstones.
