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Hydrocortisone is a corticosteroid drug used for topical atopic dermatitis treatment available in the form of a spray, rectal cream, powder for preparation and injection, ointment in concentrations: 0.5, 1, 2.5%, ear solution 1%, topical solution in…
Hydrocortisone is a corticosteroid drug used for topical atopic dermatitis treatment available in the form of a spray, rectal cream, powder for preparation and injection, ointment in concentrations: 0.5, 1, 2.5%, ear solution 1%, topical solution in concentrations: 0.1, 2.5%, rectal suppositories, suspension solution plus tablets.
Hydrocortisone gel was manufactured and evaluated in-vitro model by examining the physical and chemical properties, as well as evaluating the rheological properties with a texture analyzer, also evaluated. The stability of accelerated hydrocortisone gel, thermal, chemical and acid stability of the components were also evaluated. The feasibility study was also completed. All of these evaluations were compared relative to the commercial formulas and statistical analyzes were conducted.
The results of hydrocortisone gel compared to the commercial formula showed optimum physicochemical properties, good rheological properties, and good stability. From the general results, we can conclude that hydrocortisone gel is a practical, more effective, safe and stable formulation when compared to its counterparts.
