The Effect of the Combined Clarithromycin - Naproxen against
Streptococcus pyogen Isolated from Patients with Pharyngitis. A Pilot
Study
الباحث الأول:
Thikra Abdullah Mahmood
الباحثين الآخرين:
Iman Jabbar Kadhim, Suaad Mohammed H. Rasheed, Huda Ghaze
Hameed, Hussein Abdulkadhim
المجلة:
Indian Journal of Natural Sciences
تاريخ النشر:
None
مختصر البحث:
Streptococcal pharyngitis (sore throat) is inflammation of the mucous membranes, that line the back of
the throat or pharynx. It can cause discomfort, dryness, and difficulty in swallowing. Fifteen to 36 percent
of infected cases are group A Strep…
Streptococcal pharyngitis (sore throat) is inflammation of the mucous membranes, that line the back of
the throat or pharynx. It can cause discomfort, dryness, and difficulty in swallowing. Fifteen to 36 percent
of infected cases are group A Streptococcus . The rate of infection was 10% in adults, 20% in children,
while 10% to 25% of asymptomatic populations were carriers for group A Streptococcus. The Effect of the
Combined Clarithromycin-Naproxen against Streptococcus pyogen one away to processing of antibiotic
resistant that one problem in Iraq and the world. Early diagnosis and treatment are critical to reduce the
rate of incidence of morbidity and mortality.Aim and objective: In a manoeuver to defeat Streptococcus
pyogenes resistance and improve its response to antibiotic, non-steroidal anti-inflammatory drugs
(NSAID) are repurposed as antimicrobial activity against S. pyogen. Here, the Objective was to combine
Clarithromycin the traditional antibiotic recommendaed by FDA guideline of care, and to examine the
minimum inhibitory concentration (MIC), using Naproxen (NSAID), and to assess the combination index
(CI) against strains of Streptococcus pyogenes. A pilot study design, and randomized sampling of patients
with pharyngitis to combat the multidrug-resistant (MDR) strain of S. pyogen. The most serious isolate
was cultivated for MIC determination of Clarithromycin -Naproxen combination, in comparison with
each individually to determine.Results: There was a significant synergism between Naproxen (index ˂ 1) at P= 0.001 and Z score= 1.3. Further confirmation of MIC folds of dilutions are to
be assessed to obtain reasonable evidence.
