Histopathological, immunohistochemical and physiological study for the hepatoprotective effect of melatonin against inhrifampicin-induced hepatotoxicity in mice model
الباحث الأول:
Siham Mahmood Al-Rehemi
الباحثين الآخرين:
Rasha Hatem Dosh, Maha Jamal Frayyeh, Rihab Hameed Al Mudhafar, Hussein Abdulkadhim4
المجلة:
Wiadomości Lekarskie Medical Advances
تاريخ النشر:
9 يناير، 2024
مختصر البحث:
Aim: The purpose of this study is to assess the hepatoprotective effect of melatonin against isoniazid (INH) and rifampicin (RMP) induced hepatotoxicity in
albino mice.
Materials and Methods: Adult male mice were divided into four groups: saline, …
Aim: The purpose of this study is to assess the hepatoprotective effect of melatonin against isoniazid (INH) and rifampicin (RMP) induced hepatotoxicity in
albino mice.
Materials and Methods: Adult male mice were divided into four groups: saline, INH-RMP, INH-RMP+MT and MT were administered for 21 days. Biochemical
analyses were performed for the determination of ALT, AST. Histopathological changes in the liver and Immunohistochemical assessment to determine the
expression of Caspace3 were also examined.
Results: Biochemical analysis revealed significant increases in serum ALT and AST in INH-RMP group. Histopathological findings demonstrated severe liver damage
in INH-RMP group as compared with control group. In contrast, treatment of mice with melatonin (MT) markedly mitigated the liver injury. Immunohistochemical
findings demonstrated apoptotic marker caspace3 significantly higher in INH-RMP group as compared with control group.
Conclusions: Experimental findings highlight the potential benefits of melatonin in this model, prompting speculation on its potential application in human
therapy.
