The Cytotoxic Effect of Zinc Oxide on Colon Cancer Cell Lines
in Vitro
الباحث الأول:
Shihab Ahmed Jasim1, Nihad A. Saleh2
1Department of Physics, College of Science, Kufa University, Iraq; 2Department of Physics, College of
Science, University of Babylon, Iraq
المجلة:
Indian Journal of Public Health Research & Development
تاريخ النشر:
None
مختصر البحث:
Abstract
Background: The small size and surface properties of Zinc Oxide Nanoparticles enabled them to diffuse
easily through, and localize inside, tumor cells. The aim of current study was to evaluate the anticancer
effects of Zinc Oxide Nanopar…
Abstract
Background: The small size and surface properties of Zinc Oxide Nanoparticles enabled them to diffuse
easily through, and localize inside, tumor cells. The aim of current study was to evaluate the anticancer
effects of Zinc Oxide Nanoparticles on a colonic cancer cell line in vitro with the use of Methyl Thiazolyl
Tetrazolium assay.
Method: The cytotoxic effects of of Zinc Oxide Nanoparticles against colon cancer were planned with a
serial doubling dilution concentrations (μg/mL). The microscopic features of apoptotic cell were shown and
viability was measured by using Methyl Thiazolyl Tetrazolium assay, a reliable and common colorimetric
test for evaluation of cell viability.
Results: According to cell viability assays, 15μg/mL and 8μg/mL of Zinc Oxide Nanoparticles were found to
be highly toxic with the most potent antitumor activity on colonic cancer cell line. In addition, the obtained
results showed a major reduction in cell viability and increased apoptosis comparison with normal cell line
by same doubled increase concentrations.
Conclusion: ZnONPs can be used
