The effect of vitamin C on ovary of female white rats treated with kmno4.
Histological & physiological study
الباحث الأول:
Sami Raheem Al-Katib
الباحثين الآخرين:
Ahmed H. A. Al Azam
Sana Abadi Habeab
المجلة:
kufa jornal for veterinary medical scince
تاريخ النشر:
None
مختصر البحث:
The present study was conducted to verify the oxidative stress status by using different
doses of KMno4 (100,200,300) mg /70kg b.w and role of antioxidant agents at different
concentrations of Vitamin C (1000, 1500, 2000) mg /70kg b.w on female in…
The present study was conducted to verify the oxidative stress status by using different
doses of KMno4 (100,200,300) mg /70kg b.w and role of antioxidant agents at different
concentrations of Vitamin C (1000, 1500, 2000) mg /70kg b.w on female infertility. To
achieve this aim, 72 female rats with ages of 2-3 months, weighing( 180g-250g) Were
enrolled .To compare the results, 24 healthy individuals of ages(2-3 months) were also
studied which divided to three chief groups: treated with KMno4, Vitamin C and combination
of (KMno4+Vitamin C) . Serum Vitamin C and ovaries were dissected for histopathological
study. The results indicated a significant decrease (p<0.05) of Vitamin C values in sera of
groups that treated with (KMno4) alone, when compared with the control group, while
Vitamin C levels showed a significant (p<0.05) increase in Vitamin C treated groups in
respect with those of the control group. The highest levels of Vitamin C values were found in
the groups that combined of treated with (KMno4+Vitamin C). There was a normal
histological appearance of ovary in control group, the treatment with 1000 mg/70kg vitC. b wt
showed an increase in the blood flow within the parenchyma of ovary representing congestion
of blood vessels and numerous of growing follicles and huge graffian follicles. While
treatment with different doses of KMno4 resulted in appearance of few number of growing
follicles and huge graffian follicles. These results highlighted the involvement of the
oxidative stress in female infertility and confirmed the benefits of the use of antioxidants in
the medication of this condition, not only to improve the environment of follicles, but also to
modulate female infertility hormonal profile.
