IL-8/CD181 Mediated Inflammation in SLE-Associated Hemolytic Anemia
الباحث الأول:
Muslim Idan Mohsin
الباحثين الآخرين:
er A. MH. Al-Hilali, Rusul Idan Mohsin, Mohammed Mohasin, Mohammed Jasim Mohammed Al-Shamarti
المجلة:
Iranian Journal of Pathology
تاريخ النشر:
10 مارس، 2025
مختصر البحث:
Background & Objective: Systemic Lupus Erythematosus (SLE) is an autoimmune
disease characterized by immune dysregulation, autoantibody production, and organ
damage, notably in the kidneys. Cytokine imbalances contribute to SLE's diverse
clini…
Background & Objective: Systemic Lupus Erythematosus (SLE) is an autoimmune
disease characterized by immune dysregulation, autoantibody production, and organ
damage, notably in the kidneys. Cytokine imbalances contribute to SLE's diverse
clinical presentations. This study investigated the roles of interleukin-8 (IL-8) and its
receptor, CD181 (CXCR1), in SLE pathogenesis, specifically focusing on their
association with hemolytic anemia, a severe complication.
Methods: This research investigates the role of interleukin-8 (IL-8) and its cognate
receptor, CXCR1 (CD181). It was analyzed clinical and demographic data from 250 SLE
patients and quantified IL-8 and CD181 mRNA and protein expression in samples from
patients with active SLE, inactive SLE, and SLE complicated by hemolytic anemia,
comparing them to healthy controls.
Results: Of the 250 samples, 84% were from SLE patients, with 67% in the active
disease phase. Significant upregulation of both IL-8 and CD181 mRNA and protein
was observed in SLE patients compared to controls. Specifically, mRNA expression
was significantly elevated in active SLE (p=0.0001) and inactive SLE (p=0.01).
Notably, IL-8 mRNA expression was significantly higher in SLE patients with
hemolytic anemia (p<0.0001) compared to those without (p<0.01(.
Conclusion: These findings suggest that the IL-8/CD181 axis plays a crucial role in the
inflammatory processes and tissue damage associated with SLE, particularly in the
development of hemolytic anemia.
