The Relationship Between Extra-Coronary Calcification and Coronary Artery Lesion Characteristics
الباحث الأول:
Samir Abeid
الباحثين الآخرين:
C.Yu, K. Ho-Shon, J. Magnussen, A. Yong, C. Naoum1
المجلة:
HEART, LUNG AND CIRCULATION JOURNAL
تاريخ النشر:
None
مختصر البحث:
Background: Calcifications in non–coronary cardiac and vascular locations are frequently observed in imaging modalities, including echocardiography and non–cardiac computed tomography (CT) scans. Previous studies have shown an association between ex…
Background: Calcifications in non–coronary cardiac and vascular locations are frequently observed in imaging modalities, including echocardiography and non–cardiac computed tomography (CT) scans. Previous studies have shown an association between extra-coronary calcification and risk factors of cardiovascular disease. This study aims to investigate the prevalence of extra-coronary calcification, and explore the association with coronary disease severity and plaque characteristics.
Method: In total, 200 consecutive patients who underwent CT coronary angiography at our institution had coronary calcium score and lesion characteristics assessed by two experienced
Level B readers. The CT scans were reviewed by a third blinded reader to measure the calcium score at four extra-coronary sites including the aortic valve, mitral annulus, and ascending and descending aorta.
Results: The prevalence of extra-coronary calcification at any site was 53%. The prevalence of aortic valve, mitral annulus, and ascending and descending aorta calcification were 36.5%, 12%, 9%, and 35.5%, respectively. Patients with extracoronary calcium score (ECCS) >0 had a higher prevalence of coronary calcification than patients without extra-coronary calcification (42% vs 16.5%; p < 0.001). Extra-coronary calcium score correlated with coronary calcium score (r = 0.520; p < 0.001) and age (r = 0.632; p < 0.001). Patients with extracoronary calcification were more likely to have calcified plaques than patients with no extra-coronary calcification (67.9% vs 27.2%; p < 0.001). Patients with ECCS >400 had higher rates of significant coronary stenosis (>50% stenosis in ≥1 artery) than patients with ECCS ≤400 (55% vs 13.8%; p < 0.001).
Conclusion: An ECCS>400 was associated with the presence of significant coronary disease. The clinical relevance of extra-coronary calcification in non–coronary imaging modalities warrants further investigation.
