Association of colon Adenocarcinoma with
SNPs variation of 3-Untransulated region of
Interlukin-23 Receptor
الباحث الأول:
Alwaidh Roaa Hammed
الباحثين الآخرين:
Hashim Ali Fadhil, Al-Terehi Mona N. and Mahdi Liwaa Hussein
المجلة:
Research Journal of Biotechnology
تاريخ النشر:
10 نوفمبر، 2024
مختصر البحث:
Abstract
Background: colorectal cancer is most common cancer types that recorded in highly incidence in last decade in Iraq, multifactor have implicated in disease progressing and development, some un translated regions implicated indirectly with d…
Abstract
Background: colorectal cancer is most common cancer types that recorded in highly incidence in last decade in Iraq, multifactor have implicated in disease progressing and development, some un translated regions implicated indirectly with disease, The current study aims to detect Association the UTR of IL-23 Receptor Variations with some Adenocarcinoma histological Features.
Methods: a case control study was implemented using PCR-sequencing of UTR of IL-23 receptor gene, three SNPs were targeting in current study included (rs185937924 A>G, rs1653126126G>C and rs1300405558 T>A)
Results: the results showed that deletion mutation observed in these SNPs, there were non-significant increases in deletion mutation in patients than control group (P=0.0983), the first SNP rs185937924 A>G shows non-significant association with adenocarcinoma (P= 0.247) for AA genotype and for AG and GG genotypes (P= 0.7353). Significant association of allele frequency was observed (P=0.0457). A new allele were recorded in current study for rs1653126126 (G>A), non-significant associated with disease in all genotyping for AG (P=0.3588) and for AA (P=0.4049), allele frequency also non-significant association with disease. a new allele also was observed in rs1300405558 (T>G), the genotyping showed non-significant association with disease TG was (P=0.5554), (P=0.5288) for TT, and GG (P=0.5552), all alleles frequencies were non-significant association. Belong to tumor differentiated the target SNPs genotyping didn’t associate with well or moderate differentiation, target SNPs didn’t showed significant relations with tumor staging and T.
conclusion: from these results can be concluded that the IL-23 receptor variation in adenocarcinoma have a new alleles in study population (case and control) in the rs1653126126G>C (G>A) and rs1300405558 T<A (T<G), the new alleles didn’t associate with adenocarcinoma and with the histological features
