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Abstract: This study was designed to evaluate the effect of the oxidative stress in sera of young patients without a family history of hypertension, then find the relation of it to lipid profile. The study involved 56 young healthy (30.5 ± 4.7 years…
Abstract: This study was designed to evaluate the effect of the oxidative stress in sera of young patients without a family history of hypertension, then find the relation of it to lipid profile. The study involved 56 young healthy (30.5 ± 4.7 years) and 23 healthy elderly volunteers (66.3 ± 3.5 years), these individuals were compared with 67 patients (28.6 ± 5.0 years), attending the Gastro Intestinal and Liver Centre at Al Sader Medical City and several specialized clinics in Najaf government. Malondialdehyde level was measured by TBARS assay as reflection to the oxidative stress effect. Using standard enzymatic assays, TG, TC, HDL-C, VLDL- -C, and LDL-C values were measured for patients and controls on the same day of sample obtainment. Levels of serum MDA, TG, VLDLC, and LDL-C were significantly raised (p<0.005) in hypertensive patients group when compared with young and elderly controls, while non significant variations were obtained when the control groups were compared together. Daytime SBP and DBP were both strong positive correlated (r=0.82, p<0.005 for SBP, and r=0.95, p<0.005 for DBP) with the MDA in hypertensive patients, but in elderly controls only the correlation between SBP and MDA levels was statistically significant (r=0.61, p<0.005). Sera TG, VLDL-C, and LDL-C levels showed the same of MDA results when they were correlated to SBP and DBP, while correlations between blood pressure with sera TC were moderate positively in the study groups. In spite of; HDL-C levels in hypertensive patients were within the levels of those of two control groups, HDL-C levels showed negatively correlation with both SBP and DBP. Notably, there was a positive correlation (r=0.60, p<0.005) between serum LDL-C levels and SBP of elderly controls, no such correlations were observed when the relation was between Daytime SBP and DBP and VLDL-C or LDL-C of young controls. the highly significant positive correlation (r = 0.94 at p<0.005) of MDA and TG of the hypertensive patients. Significant positive correlations were also observed for MDA with VLDL-C (r = 0.74 at p<0.005), and with LDL-C (r = 0.71 at p<0.005). It is well known that the endogenous female sex hormones have significant effect on lipid levels, according to that, testing the gender effect was occurred. MDA level in the study subgroups revealed a significant increase (p<0.005) in male patients when compared to females, while, student's t-test failed to exhibit significant changes among male and female subgroups in the control groups. Except for the significantly variation (p<0.005) of TG in the patient subgroups, all the other lipid profile parameters showed no significant differences between male and female subgroups. Concerning the controls subgroups, TG, TC, HDL-C, VLDL-C, and LDL-C were comparable between male and female subgroups. Finally, treatment for hypertension is similar for all demographic groups, but socioeconomic factors and lifestyle may be barriers to BP control in some patients, therefore; dealing with transitory hardships and arrangement of food style may be consider as a prim factors in the hypertension treatment. Key words: oxidative stress, lipid profile, hypertension
