Synthesis some of hetrocyclic compounds of Meldrums acid derivatives and study the biological activity
الباحث الأول:
Rajaa Abd AL-Ameer
الباحثين الآخرين:
Dr.Naji Mousa Ali ,Dr.Hssan thamer GHhanime
المجلة:
International Journal of A advanced Research
تاريخ النشر:
None
مختصر البحث:
This paper involves synthesis of some heterocyclic compound derivative from Meldrum's acid ,by reaction of Meldrum's acid , indol and p-hydroxy benzaldehyde and catalyst L-proline in aceto nitrile to produce Meldrum's acid derivative (P),compound…
This paper involves synthesis of some heterocyclic compound derivative from Meldrum's acid ,by reaction of Meldrum's acid , indol and p-hydroxy benzaldehyde and catalyst L-proline in aceto nitrile to produce Meldrum's acid derivative (P),compound (P) ethanolysis to give ester derivative (P1),the compound (P1) reacted with hydrazine hydrate to give hydrazide derivative compound (P2) ,hydrazide derivative reacted with p-hydroxy benzaldehyde in absolute ethanol to give Schiff base derivative(P3),shiff base derivative using to prepare some new heterocyclic compounds by multi step reactions and reactant with different solvent and materials to prepare four ,five and seven ring membered . The prepared compounds were characterized by FT-IR ,H1NMR,13CNMR .All the prepared compounds were studied the antibacterial activity.
