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Thrombocytopenia is a condition characterized by abnormal decrease of platelet count in the blood. Some etiologies indicated that leukemia is one of its causes. This study dealt with platelet indicators that are not commonly used in pathological fie…
Thrombocytopenia is a condition characterized by abnormal decrease of platelet count in the blood. Some etiologies indicated that leukemia is one of its causes. This study dealt with platelet indicators that are not commonly used in pathological fields. In addition to the platelet count (PLT), these indicators included: mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), and platelet large cell ratio (P-LCR). Despite many studies increasingly reported about these parameters. Additionally, the mechanisms-insufficient production and destruction of platelets may be measured by platelet and it's cooperative to evaluate the primary cause of thrombocytopenia. To investigate the significance of platelet indices by estimation of the ineffective platelet production in patients with Acute lymphoblastic leukemia (ALL) and Acute myeloid leukemia (AML). This study included 28 patients with acute leukemia, 11 of whom were ALL (mean age: 25.64±14.76, range: 12–49 years old) and 17 AML (mean age: 31.59 ±13.49, range: 8–50 years old), in addition to 15 normal, age- and sex-matched individuals as control. Where blood samples were collected from them and all the above tests were performed. The sensitivity and the specificity of each item to differentiate ALL and AML were determined by receiver operating characteristic (ROC) curve analysis. Leukemia patients (n=28, male 18 (64.3%), and female 10 (35.7%) were significantly (p<0.0001) decreased in WBC, RBC, Hb, MPV, PLT, PCT, while significantly higher (p<0.05) in P-LCR, and PDW as compared with the healthy controls (n=15). Also, these parameters a higher significant when compared between ALL and AML patients, except WBC, PLCR, and PDW showed no significant differences between these patients. ROC test showed that MPV and PLC have higher area under curve (0.763, sensitivity=0.65, specificity=0.36, p=0.005, and 0.940, sensitivity=0.82, specificity=0.18, p=0.0001) respectively, for discriminating the leukemia and healthy controls group. A negative (p <0.001) correlation among platelet counts with MPV (r= -0.670), PLC (r= -0.666), PLCR (r= -0.701), and PDW (r= -0.705), also a positive correlation between them of platelet indices in leukemia patients.
