Design and Synthesis of new Naproxen Analogues as Potential Antiinflammatory
Agents
الباحث الأول:
Noor H. Nasser
الباحثين الآخرين:
Nethal H. Hammud, Samer A. Hasan, Abbas Hamid Abdalsadh, and
Ahmed kareem Hussein
المجلة:
Al-Mustansiriyh Journal of Pharmaceutical Scienses
تاريخ النشر:
None
مختصر البحث:
4-aminobenzenesulfonamide derivatives were linked to α-carbon of naproxen a nonselective
non-steroidal anti-inflammatory drug (NSAID) to increase its size, so; increase its
selectivity toward COX-2 enzyme, rather than COX-1 enzyme, that lead to re…
4-aminobenzenesulfonamide derivatives were linked to α-carbon of naproxen a nonselective
non-steroidal anti-inflammatory drug (NSAID) to increase its size, so; increase its
selectivity toward COX-2 enzyme, rather than COX-1 enzyme, that lead to reduce
gastrointestinal side effects of this drug.
The chemical structures of the synthesized compounds and their intermediates were
confirmed and characterized using elemental microanalysis (CHN), FTIR, and other
physicochemical properties like melting points, Rf values.
