Insulin-like Growth Factor-2 Binding Protein-2 Gene Polymorphisms in Iraqi Patients with Type 2 Diabetes Mellitus
الباحث الأول:
Zubaida Falih 1Department of Clinical Laboratory Sciences, Faculty of Pharmacy, University of Kufa, Kufa, Iraq
الباحثين الآخرين:
Bayadir Ali Wannas Khodair2, Noaman Ibadi Mohammed2, Tahseen Kadhem Mohammed1 2Department of Physiology, Faculty of Veterinary Medicine, University of Kufa, Kufa, Iraq
المجلة:
Open Access Macedonian Journal of Medical Sciences.
تاريخ النشر:
None
مختصر البحث:
BACKGROUND: Type 2 diabetes mellitus (T2DM) represents a hyperglycemia causing metabolic disease which exists in the peripheral tissues due to insufficient insulin secretion or insulin resistance. Genetic association researches had suggested that th…
BACKGROUND: Type 2 diabetes mellitus (T2DM) represents a hyperglycemia causing metabolic disease which exists in the peripheral tissues due to insufficient insulin secretion or insulin resistance. Genetic association researches had suggested that the single-nucleotide polymorphisms (SNPs) spanning IGF2BP2 gene are associated with the progression as well as development of the T2DM.
AIM: This study aims to evaluate the association of IGF2BP2 gene polymorphisms (rs4402960 and rs1470579) with T2DM in a sample of Iraqi individuals.
METHODS: A case–control study has been conducted on 800 participants, they were divided into two equal groups, which are a healthy control group (400) and type 2 diabetic patients (400). Fasting blood sugar (FBS), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and HbA1c were measured for both participant groups. IGF2BP2 gene was genotyped for polymorphisms; rs4402960 and rs1470579 using the PCR-RFLP technique.
RESULTS: The SNP rs4402960 minor allele frequency of T allele was considerably different between the two participating groups with 33.6% in T2DM group. Homovariant TT shows a significant odds ratio (4.5) as codominant type. The rs1470579 SNP shows a significant risk (1.28) of C allele in the patients group than in A allele. The CC genotype in codominant and recessive models shows significant odds ratio differences (2.03 and 1.96), respectively. The rs1470579 SNP exerts significant differences as codominant model in biochemical features of BMI, fasting blood glucose, insulin, and HOMA-IR. The study power of rs4402960 is 69.5% and rs1470579 is 34.1%.
CONCLUSION: This study confirmed the association of rs4402960 as codominant, dominant, and recessive with T2DM significantly. However, rs1470579 is associated as recessive model with T2DM in Iraqi population.
