مختصر البحث:
-Background: Polycystic ovarian syndrome (PCOS)
considered one of the main complex and heterogeneous endocrine
syndromes of females in the pregnancy age , it is commonly
accompanied by insulin resistance (IR). Current study aimed to
compare …
-Background: Polycystic ovarian syndrome (PCOS)
considered one of the main complex and heterogeneous endocrine
syndromes of females in the pregnancy age , it is commonly
accompanied by insulin resistance (IR). Current study aimed to
compare adiponectin and ghrelin levels between females with PCOS
and healthy females, also inspect the association between ghrelin and
adiponectin levels in addition to predict their use as diagnostic factors
for the disease, finally to study the connection between adiponectin
and ghrelin with lipid profiles and IR in PCOS females . Subjects and
Methods: The present case-control study involved 120 females; 60
with PCOS and 60 age-matched healthy controls. Fasting serum levels
of glucose, lipid profiles, insulin, adiponectin, ghrelin, follicle
stimulating hormone (FSH), luteinizing hormone (LH), testosterone
and sex hormone-binding globulin (SHBG), were assessed. Insulin
resistance was assessed by homeostasis model assessment (HOMA-IR)
and body mass index (BMI) also estimated. The statistical analysis of
the data were done by using SPSS 22 . Results: The findings revealed
that serum adiponectin level elevated significantly in females with
PCOS as compared with control, while ghrelin level decreased
significantly in females with PCOS in compared to control.
Furthermore, results showed that adiponectin levels were positively
correlated with BMI, fasting glucose (FG), low density lipoproteincholesterol (LDL-C), triglycerides (TG), total cholesterol (TC), insulin
resistance (HOMA-IR), insulin, LH, FSH, and SHBG in PCOS females;
while it was negatively correlated with high density lipoproteincholesterol (HDL) and ghrelin. On the other hand, ghrelin levels were
negatively correlated with BMI, TC, TG, LDL, LH, FSH and
adiponectin; but it was positively correlated with FG, HDL, insulin,
HOMA-IR, and SHBG. Conclusion: Patients with PCOS have increased
levels of adiponectin and decreased levels of ghrelin than that of
control group. Also adiponectin was positively correlated with lipid
profile and BMI; while ghrelin negatively correlated with them. For
this, adiponectin and ghrelin levels may be beneficial in assessing
metabolic abnormalities in PCOS.
Keywords---Polycystic ovarian syndrome; Adiponectin; Ghrelin;
Insulin resistance.
