SYNTHESIS AND IDENTIFICATION OF SEVERAL SCHIFF BASES
DERIVATIVES AND THEIR ANTIBACTERIAL ACTIVITY ON
COMMON PATHOGENIC BACTERIA
الباحث الأول:
Zahraa Yosif Motaweq
الباحثين الآخرين:
Hawraa Mohammed Sadiq, Nibras Yahya Alsallamiand,
Mohauman Mohammad AL-Rufaie*
المجلة:
World Journal of Pharmaceutical Research
تاريخ النشر:
None
مختصر البحث:
ABSTRACT
This research involves synthesis of some Schiff base compounds [A1-
A3] were prepared from condensation of [4-(dimethylamino)
benzaldehyde and 4-hydroxy benzaldehyde and 4-chloro
benzaldehyde] in absolute ethanol. Each from the prepared…
ABSTRACT
This research involves synthesis of some Schiff base compounds [A1-
A3] were prepared from condensation of [4-(dimethylamino)
benzaldehyde and 4-hydroxy benzaldehyde and 4-chloro
benzaldehyde] in absolute ethanol. Each from the prepared
compounds are distinguished with [FT.IR] spectroscopy, additionally
to the progression of the steps of reaction through the technique of
[TLC], by utilizing (ethanol-toluene,1:1) as solvent .The following
scheme[1] explains the steps of reaction and the prepared compounds.
Antibacterial efficiency of A1, A2 and A3 compounds were tested
against eight human pathogens like two gram +ve bacteria
(Staphylococcus aureus, Streptococcus agalactiae) as well as five
gram -ve bacteria (Escherichia coli, Enterobacter cloacae, Proteus mirabilis, Klebsiella
pneumoniae, Pseudomonas aeroginosa and Salmonella typhi) using agar well diffusion
method. All compounds showed significant activity against pathogenic bacteria, but the A2
compound showed maximum inhibition zone and antibacterial activity against all pathogenic
bacteria. The minimum inhibition zone was determined in A3 compound showing less
antibacterial activity against the experimental bacteria.
