Synthesis of a new organic probe
4-(4 acetamidophenylazo) pyrogallol for
spectrophotometric determination of Bi(III)
and Al(III) in pharmaceutical samples
الباحث الأول:
Jumana W. Ammar
الباحثين الآخرين:
Zainab A. Khan, Marwa N. Ghazi, and Naser A. Naser
المجلة:
Reviews in Analytical Chemistry
تاريخ النشر:
None
مختصر البحث:
A modern development discusses the synthesis
and validity of simple, sensitive, and versatile spectrophotometric
methods for Bi(III) and Al(III) determination in
pharmaceutical formulations have been conducted. In the
present paper, 4-(4 acetami…
A modern development discusses the synthesis
and validity of simple, sensitive, and versatile spectrophotometric
methods for Bi(III) and Al(III) determination in
pharmaceutical formulations have been conducted. In the
present paper, 4-(4 acetamidophenylazo) pyrogallol has
been synthesized as a new organic compound, 4-APAP,
by coupling pyrogallol in a regulated pH medium with
diazotized p-aminoacetanilide. 4-APAP was identified by
methods of FT-IR, 1H-NMR, 13C-NMR, and thermal analysis
(thermogravimetry and differential scanning calorimetry).
Solvatochromic activity was also studied in solvents
with different polarities. The Kamlet and Taft linear solvation
energy relationship was used to correlate shifts in
UV-Visible spectra of 4-APAP with Kamlet-Taft parameters
(α, β, and π*). The optimum assay conditions showed linearity
from 0.3-13 to 0.5-11 μg‧mL-1 for Bi(III) and Al(III), respectively.
Molar absorptivity values were 3.365 × 104 and
0.356 × 104 L‧mol-1‧cm-1 for Bi(III) and Al(III), with similar
Sandell’s sensitivity measures of 0.006 and 0.008 μg‧cm-2.
Detection limits and quantification limits were 0.013 and
0.043 μg‧mL-1 for Bi(III), respectively, and 0.018 and
0.059 μg‧mL-1 for Al(III) with the relative standard
deviation
for determination of both metal ions using 4-APAP
probe being <2.0%. The validity, accuracy, and efficiency
of the approaches were demonstrated by the determination
of Bi(III) and Al(III) in different formulations.
