The Association of Angiotensin-Converting Enzyme 2
Polymorphism and SARS-CoV-2 Infection in the Iraqi
Population
الباحث الأول:
Nima Mezher, M
الباحثين الآخرين:
AL-Mudhafar, M. A
Noaman, I. M
المجلة:
Razi Vaccine & Serum Research Institute
تاريخ النشر:
None
مختصر البحث:
The quick and advancing prevalence of the new coronavirus SARS-CoV-2 produced a global crisis surge with a
profound impact on human health and worldwide economic constancy. The virus is known as one strain of
coronavirus, which causes the respir…
The quick and advancing prevalence of the new coronavirus SARS-CoV-2 produced a global crisis surge with a
profound impact on human health and worldwide economic constancy. The virus is known as one strain of
coronavirus, which causes the respiratory infection responsible for the current pandemic of COVID-19. The
virus spike protein has a high binding affinity to human ACE2, depending on crystallization analysis and
biochemical interaction studies. Studies consistently reveal that rs2285666, a polymorphism found in ACE2,
diverse significantly between Europeans and Asians, changing ACE2 expression. The alternating allele TT of
rs2285666 SNP increased gene expression to 50%; thus, it may have a role in SARS-COV-2 infection
vulnerability. This study aimed to investigate rs2285666 SNP association with SARS-CoV2 infection as a first
report in the Iraqi population. Fifty (20 Male/30 Female) Covid-19 patients with severe symptoms with mean
age (of 41.5±10.7) and 50 (20 Male/30 Female) healthy people as a control group with mean age (of 41.5±10.7)
were included in this study. Sample of a patient tested as a mutant genotype (TT) by RFLP assay. The results
reveal a MAF value of 0.3 for this gene in Iraqi samples, more than Europeans (0.2) and less than East Asians
(0.55). The codominant model had significant OR of both alleles CT and TT (OR=4.26 & 6.7; P-value=0.012 &
0.023 respectively). In conclusion, there is an association between increased severity of SARS-Cov-2 infection
and rs2285666 polymorphism of the codominant genotype model of the Iraqi population. However, several
other factors may affect disease severity, such as ethnic group differences, sex, comorbidity, virus strain, and
others.
Keywords: Angiotensin-Converting Enzyme 2, Polymorphism, SARS-CoV-2
