Synthesis, characterization, and anti-parasitic activity evaluation of the synthesized chalcone against Toxoplasma Gondii isolated from cases of abortion in AL -Najaf city”
الباحث الأول:
Muna Hashim Ghazzay
الباحثين الآخرين:
Samer Ali Hasan, Oun Deli Khudhair, Khalida Kadhim Abbas
Al-Kelaby, Emad Sadiq Ali Al-Hilli1
المجلة:
Journal of Medicinal and Chemical Sciences
تاريخ النشر:
5 مارس، 2025
مختصر البحث:
Toxoplasmosis is a well-known and widespread parasite infection. Although
diagnosis has come a long way, therapeutic approaches have not changed
since the 1940s. Using SOCl2/EtOH as a catalyst, the Claisen-Schmidt
condensation method has been use…
Toxoplasmosis is a well-known and widespread parasite infection. Although
diagnosis has come a long way, therapeutic approaches have not changed
since the 1940s. Using SOCl2/EtOH as a catalyst, the Claisen-Schmidt
condensation method has been used in this study to effectively synthesize
chalcone. The anti-parasitic effect of the synthesized chalcone was evaluated
at doses of 1, 10, 50, 100, 250, 500, and 1000 μg/ml against isolated
Toxoplasma Gondii from aborted cases compared with spiramycin. The
isolated T. Gondii in this therapeutic investigation was used as strong
positive specimens for inoculum on Vero cells for parasite propagation. A
significant reduced the fold expression values (2^-ΔΔCT), which are a
measure of how well chalcone inhibits the proliferation of parasites.
Compared with spiramycin, which demonstrated an IC50 of 281.19 g/mL,
chalcone has an inhibitory concentration (IC50) of 142.9 μg/mL. The results
of this study reveal that chalcone can be used as a medication to treat
toxoplasmosis because it had an antiparasitic impact on T. Gondii. To assess
the therapeutic index of chalcone, molecular, synergistic, and in vivo
monitoring investigations are essential.
