مختصر البحث:
Background: Toxoplasma gondii is an obligate intracellular protozoan parasite that infects various organs, including the liver, and infects a wide variety of warm-blooded animals, including an estimated one-third of the global human population. Alth…
Background: Toxoplasma gondii is an obligate intracellular protozoan parasite that infects various organs, including the liver, and infects a wide variety of warm-blooded animals, including an estimated one-third of the global human population. Although infection is often asymptomatic in immunocompetent individuals, chronic toxoplasmosis may cause subclinical hepatic and metabolic alterations. This study aimed to investigate the impact of T. gondii on the lipid profile and liver function in women. Methods: A Comparative Study was conducted with 88 females aged 18-50 years in Al Najaf province. Anti-Toxoplasma IgG antibodies were detected using a VIDAS, where the liver enzymes, including ALP, AST, and ALT, as well as the lipid profiles, including TC, TG, HDL, VLDL, and LDL, were measured using biochemical methods. Statistical analysis was performed using Student's t-test. Results: The current study showed that the concentrations of ALT in patients with Toxoplasmosis significantly increased (P<0.05) (31.88 ± 3.49 U/L) compared to the control group (20.85 ± 3.02 U/L). Furthermore, the concentrations of ALP and AST in patients with Toxoplasmosis non-significantly increased (P>0.05) (95.27 ± 17.77 U/L) and (29.37 ± 3.17 U/L), respectively, compared to the control group (85.13 ± 6.95 U/L) (27.17 ± 3.97 U/L), respectively. Where the concentrations of TG, TC, HDL, VLDL, and LDL in patients with Toxoplasmosis were significantly increased (P<0.05) (231.6 ± 3.676 mg/dL), (156.1 ± 8.896 mg/dL), (41.17 ± 1.55 mg/dL), (46.31 ± 8.92 mg/dL), and (69.75 ± 8.92 mg/dL) respectively compared to the control group (97.83 ± 11.46 mg/dL), (83.15 ± 4.197 mg/dL), 29.82 ± 0.319 mg/dL, (19.57 ± 2.29 mg/dL), and (33.77 ± 4.32 mg/dL) respectively. Conclusion: The chronic infection with T. gondii in women was linked with slight hepatic involvement and important disturbances in lipid metabolism. These results imply that toxoplasmosis may play an important role in liver dysfunction and dyslipidemia, which means the need for routine biochemical monitoring in individuals who are infected
