Approach to enhance antibiotics efficiency towards uropathogenic bacteria
الباحث الأول:
Mohammed Jasim Alshamarti
المجلة:
Malaysian Journal of Microbiology
تاريخ النشر:
None
مختصر البحث:
Urinary tract infection (UTI) is a common infection caused by many virulent bacteria. Multidrug resistance (MDR)
by bacteria represents a major therapeutic challenge worldwide. MRD bacteria have different mechanisms to avoid
antibiotics; one of th…
Urinary tract infection (UTI) is a common infection caused by many virulent bacteria. Multidrug resistance (MDR)
by bacteria represents a major therapeutic challenge worldwide. MRD bacteria have different mechanisms to avoid
antibiotics; one of them is horizontal gene transfer. Such genes, encoding antimicrobial resistance, are easily transferred
from one bacterium to another. Magnesium and calcium chloride (MgCl2 and CaCl2) have an effect on the permeability
of bacterial cell membrane. We aimed these chemical materials could increase the antibiotics efficiency on multidrug
resistance bacteria. 250 UTI specimens were collected to isolate multidrug resistant bacteria. Depending on antibiotics
resistance, we selected three species of virulent bacteria: Escherichia coli, Staphylococcus aureus and Proteus
mirabilis. Then, we tested the effect of MgCl2 and CaCl2 on their antibiotics resistance.
