Detection of Plasmid Profile Coding Antibiotic Resistance of Klebsiella spp. Isolated from Different infections
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تدريسي في جامعة الكوفة كلية العلوم.
استاذ علم الاحياء الجزيئي في قسم التحليلات المرضية. حاصل على شهادة الدكتوراه من جامعة شفيلد/ المملكة المتحدة باختصاص علم الاحياء الجزيئي. حاصل على شهادة البكالوريوس والماجستير من جامعة الكوفة / كلية العلوم/ قسم علوم الحياة.
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Antibiotic resistance in urinary tract infection (UTI) is increasing nowadays, therefore, the aim of this study was to evaluate the resistance patterns of many pathogens toward several antibiotics that are in common use in our hospitals.
Urinary tract infection (UTI) is a common infection caused by many virulent bacteria. Multidrug resistance (MDR) by bacteria represents a major therapeutic challenge worldwide. MRD bacteria have different mechanisms to avoid antibiotics; one of them is horizontal gene transfer. Such genes, encoding antimicrobial resistance, are easily transferred from one bacterium to another. Magnesium and calcium chloride (MgCl2 and CaCl2) have an effect on the permeability of bacterial cell membrane. We aimed these chemical materials could increase the antibiotics efficiency on multidrug resistance bacteria. 250 UTI specimens were collected to isolate multidrug resistant bacteria. Depending on antibiotics resistance, we selected three species of virulent bacteria: Escherichia coli, Staphylococcus aureus and Proteus mirabilis. Then, we tested the effect of MgCl2 and CaCl2 on their antibiotics resistance.