Mono- and bis-N-heterocyclic carbene silver(I) and palladium(II)
complexes: Synthesis, characterization, crystal structure and in vitro
anticancer studies
الباحث الأول:
Mohammed Z. Ghdhayeb
الباحثين الآخرين:
Rosenani A. Haque , Srinivasa Budagumpi ,
Mohamed B. Khadeer Ahamed, Amin M.S. Abdul Majid
المجلة:
Polyhedron
تاريخ النشر:
None
مختصر البحث:
The benzimidazolium salt 1, with butyl and allyl substituents, demonstrated two types of coordination
behavior with the silver(I) center, in which the bis-NHC complex 2 was formed at room temperature,
while the mono-NHC complex 3 was formed at an …
The benzimidazolium salt 1, with butyl and allyl substituents, demonstrated two types of coordination
behavior with the silver(I) center, in which the bis-NHC complex 2 was formed at room temperature,
while the mono-NHC complex 3 was formed at an elevated temperature. However, the reaction of analogous
salts with silver(I) oxide under the same reaction conditions did not result in the formation of
mono-NHC complexes, instead bis-NHC complexes were formed. A series of palladium(II)-NHC complexes,
4, 5, 10 and 11, were obtained by the treatment of the corresponding silver complexes with a palladium(
II) source. All new compounds were characterized by various spectroscopic and analytical
techniques. Additionally, the structure of the mono-NHC silver complex 3 was unambiguously established
following single crystal X-ray diffraction method. The in vitro comparative evaluation of the salt
1, and the silver complexes 2 and 3, and all the palladium complexes for their anticancer properties
against human colon cancer cells indicated that the silver complexes 2 and 3 and palladium complexes
10 and 11 were the most effective antiproliferative compounds and were found able to promote a growth
inhibitory effect with IC50 values in the range 10.6 ± 1.8–21.4 ± 2.1 lM.
