Oxidative Stress in Primary Infertility of Women
الباحث الأول:
Majid K. Hussain
الباحثين الآخرين:
Hamza J. Mohammed, Basima S. Al- Ghazali & Mazin
Thamir Abdul Hasan
المجلة:
Global Journal of Medical research
Orthopedic and Musculoskeletal System
تاريخ النشر:
None
مختصر البحث:
The current study was designed to investigate the changes of oxidative stress (OS) in primary infertility of
females. To achieve the intended aim, 84 infertile women of ages 28.66 ± 6.29 years (mean ± SD) and 30 healthy
fertile women of ages 30.3±…
The current study was designed to investigate the changes of oxidative stress (OS) in primary infertility of
females. To achieve the intended aim, 84 infertile women of ages 28.66 ± 6.29 years (mean ± SD) and 30 healthy
fertile women of ages 30.3± 6.45 years (mean±SD) were enrolled. The levels of malondialdehyde (MDA), catalase
(CAT) and glutathione-S-transferase (GST) were determined by spectrophotometric methods. Serum follicule
stimulating hormone (FSH) and luteinizing hormone (LH) levels were measured by an enzyme linked fluorescent
assay (ELFA). The results indicated a significant (p<0.001) increase of MDA concentration and significant (p<0.001)
decreases of CAT and GST activities in the infertile women when compared with those of the control group. The
linear regression analysis demonstrated significant (r = 0.27,p<0.05) positive correlation for MDA levels and
significant negative correlations for CAT (r = - 0.24, p<0.05) and GST levels (r = - 0.26,p<0.05) with the age of
infertile women.
Changes of oxidative stress was observed to be dependent on the body mass index (BMI) and the duration
of infertility of the enrolled women. The changes of MDA, CAT and GST levels seem to be independent on etiology of
infertility and the menstruation pattern. The2linear regression analysis revealed significant (r = 0.28, p<0.05) positive
correlation for MDA levels with the FSH concentration and significant(r = - 0.29, p<0.05) negative correlation with
the LH concentration.CAT exhibited significant (r = 0.30, p<0.05) positive correlation with the FSH concentration,
while GST activity demonstrated significant(r = 0.24, p<0.05) positive correlation with the LH concentration.
These results suggest that oxidative stress is involved in the path ophysiology of primary infertility in
females, in particular through the directing of gonadotrophin changes in these patients
